DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif18a

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_956533.1	Gene:	kif18a / 393209	ZFINID:	ZDB-GENE-040426-862	Length:	895	Species:	Danio rerio

Alignment Length:	660	Identity:	204/660 - (30%)
Similarity:	312/660 - (47%)	Gaps:	139/660 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE------------KIERKQPK--TFAF 56
            :||.|||||.|.:|.:.:.|.:|.:.....::.:|...|            .:.::..|  .|.|
Zfish    10 VKVVVRVRPLNDKEKDGNFKKVVHVVDNHMLVFDPKEEEVTFFRGQRVGNRDVRKRANKDLKFVF 74

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|     .:|  :||..||:...:.|:|....|||..:||||.||:||::||:||..|.|::.
Zfish    75 DSVF-----GEE--SSQIEVFENTTKAIVDGVLNGYNCTVFAYGATGAGKTHTMLGTSNSPGVMF 132

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            ....:||:.: :....:.::.|..||:|:|||::.|||   .|...|.|||....|..|.||:..
Zfish   133 LTMKELFARM-DLIKEDKVFNVAFSYLEVYNEQIRDLL---TNSGPLAVREDGSNGVVVQGLTLH 193

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.:.|...:..||::||...|:|||.||||||||.:.|.|  .|:...:: ..:|::|||:|
Zfish   194 QPKSAEHILEALDYGNRNRTQHPTDMNATSSRSHAVFQIYLRQ--QDKTASLNPNVRVAKMSLID 256

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..|...|.||:||:|||:||..||.||:.||:....|     ..:|||||.||.||||
Zfish   257 LAGSERASATNTKGARLREGANINRSLLALGNVINTLANPKCKK-----THIPYRDSKLTRLLKD 316

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            :||||.||||:|.:|||:.:||:|.:||:||:|||.|.:                     ||||.
Zfish   317 SLGGNCRTVMIANVSPSSLSYEDTHNTLKYANRAKEIKS---------------------TLRSN 360

  Fly   381 LKHATGSPVGD---VQDKLAESENLMKQISQTWEEKLVKTER-----IQNERQQALEKMGISVQ- 436
            :. :..|.:|.   :.:|......::||..:.:||:  |.|.     |..:::...|||..|::
Zfish   361 VM-SLDSHIGQYAIICEKQKAEIVMLKQKLKEYEER--KAEAPALNPISIQKRAEFEKMSESLRS 422

  Fly   437 --ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQ-----PD----------- 483
              :..:|:.|.     :|:.:..|||       .|..:..|....||     ||
Zfish   423 VFSDRLKLRKE-----HLDIEKQLNE-------SRLTMRHRESWHQQSLIFFPDNKAERATCKYE 475

  Fly   484 IQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK 548
            .:|:.|....||         |....::..:||......:.:  ::|..::|..:.|
Zfish   476 RKLASLKSHQEH---------LQQRLMESEKCFQENEGWLHR--IENEMKLLGHDGH-------- 521

  Fly   549 SNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYER 613
                        ||.:|           :.||....:|..|:.|: ||.|.....:..|.||...
Zfish   522 ------------TPEEL-----------KKELQCHQLQLQISDLQ-QHMEHMSHLISVQDQENTH 562

  Fly   614 QFQQLRNILS 623
            ..:.:..:||
Zfish   563 THKLVNALLS 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	148/367 (40%)
		KISc	6..359	CDD:214526	148/367 (40%)
		Kinesin_assoc	356..468	CDD:292801	24/122 (20%)
		FHA	446..546	CDD:238017	20/115 (17%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif18a	NP_956533.1	KISc	9..354	CDD:214526	147/361 (41%)
kif18a	NP_956533.1	KISc_KIP3_like	9..353	CDD:276821	147/360 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910