DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Klp67A

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001286999.1	Gene:	Klp67A / 39068	FlyBaseID:	FBgn0004379	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	808	Identity:	232/808 - (28%)
Similarity:	363/808 - (44%)	Gaps:	192/808 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNP-------------PPLEKIERKQPK--TFA 55
            |||||||||:|.||:|...:.|:::..:..:|.:|             .|...|.::..|  |..
  Fly     9 IKVAVRVRPYNVRELEQKQRSIIKVMDRSALLFDPDEEDDEFFFQGAKQPYRDITKRMNKKLTME 73

  Fly    56 FDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGII 120
            ||..|      |.:.::|:...:|.. .::|....|||..:|.||.||:||::||:|::...|:.
  Fly    74 FDRVF------DIDNSNQDLFEECTA-PLVDAVLNGYNCSVFVYGATGAGKTFTMLGSEAHPGLT 131

  Fly   121 PRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQ 185
            ......||..|..:|... .:.|.|||:|:|||.|.:||   .....||:||.| .|..|.||..
  Fly   132 YLTMQDLFDKIQAQSDVR-KFDVGVSYLEVYNEHVMNLL---TKSGPLKLREDN-NGVVVSGLCL 191

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            ..:.|.:::..::..||..||...|:.|||||||||:|.|.:.  :|::.|..  ::..::|::|
  Fly   192 TPIYSAEELLRMLMLGNSHRTQHPTDANAESSRSHAIFQVHIR--ITERKTDT--KRTVKLSMID 252

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..|..:|.|.|||::|||||..||..|:||||        ..|.:|||||.||.:|||
  Fly   253 LAGSERAASTKGIGVRFKEGASINKSLLALGNCINKLAD--------GLKHIPYRDSNLTRILKD 309

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            :||||.||:|||.:|.|:..||:|.:||:||.|||:|                         |:.
  Fly   310 SLGGNCRTLMVANVSMSSLTYEDTYNTLKYASRAKKI-------------------------RTT 349

  Fly   381 LKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKN 445
            ||.       :|......:|..:|:|    :|.:.:.||:: ||.:|||.....::.:|
  Fly   350 LKQ-------NVLKSKMPTEFYVKKI----DEVVAENERLK-ERNKALEAKATQLERAG------ 396

  Fly   446 KYYLVNLNADPSLNELLVYYLK-DRTLIGGRTISGQQPDIQLSGLGIQPEHCVI----TIEDSGL 505
                 |...||.  ||..:|.| |......|       .:|...||::.:...|    |::..
  Fly   397 -----NSGFDPL--ELKTWYSKIDAVYAAAR-------QLQEHVLGMRSKIKNINYRQTLKKE-- 445

  Fly   506 YMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTS-MCASEPQTPAQLIDYN 569
             :|..:...|       |::...|         ..|.|..:..|..|| |...:.:.|:.|....
  Fly   446 -LEEFRKLMC-------VDQRVCQ---------EDFRRFANYMSTLTSQMEKYKEELPSWLSKME 493

  Fly   570 FARDEI--MQNELS-NDPIQTAIARLERQHEEDKQVALEKQ----------RQE-------YERQ 614
            .|..::  ::.|:: :...|..|..::   .:|.::.|.||          .||       ..:.
  Fly   494 IAYQDLESLKREVNKSKAYQILIVYVK---YKDLELQLTKQNIFNNHVNAINQELVENLDLMRKS 555

  Fly   615 FQQLRNILSPSTPYAPYAPYDPLRMG-KITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRA 678
            |:....:|:.:        ||.|..| |:||              |.:.:|.|.|.:::.....|
  Fly   556 FRTACEVLNQT--------YDRLEDGQKLTP--------------EIEAVFERLLRKMRFADSEA 598

  Fly   679 NSLVQEANFL---------AEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQ 734
            |:.:.|.|.|         |:|.|:.| .|:|..      :..|:|.|..|:..:.:...:..||
  Fly   599 NTKMAEMNPLAVPVALRSSAQEEEEPT-CSLTAS------AKKRQRQAAQSDDDLHLSMEDFDSQ 656

  Fly   735 IWTMEKLENKLIDMREMYQEHKE-RVLN 761
                    :...|..|:::..|. |.||
  Fly   657 --------DTESDSEELHRTFKRPRNLN 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	144/367 (39%)
		KISc	6..359	CDD:214526	144/367 (39%)
		Kinesin_assoc	356..468	CDD:292801	23/112 (21%)
		FHA	446..546	CDD:238017	20/104 (19%)
		KIF1B	741..786	CDD:289208	6/22 (27%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Klp67A	NP_001286999.1	KISc	8..353	CDD:214526	147/399 (37%)
Klp67A	NP_001286999.1	KISc_KIP3_like	8..346	CDD:276821	143/360 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940