DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and Klp64D

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	653	Identity:	207/653 - (31%)
Similarity:	312/653 - (47%)	Gaps:	133/653 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDE 68
            :.::|.||.||.::.|:.......:.::|....:....| .....:.|||:.||:.|       :
  Fly    19 ENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKP-NATANEPPKTYYFDNVF-------D 75

  Fly    69 NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQES---KGIIPRLCDQLFSA 130
            ..::|..::....|.|:|...:|||..|.||||||:||:|||.|..:|   |||||.....:|..
  Fly    76 GGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTKGIIPNAFAHIFGH 140

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDID 195
            || |:.....:.|.|||||||||:|.|||.....| ||:|:|...:|.:|..||...|.:..|::
  Fly   141 IA-KAKENQKFLVRVSYMEIYNEEVRDLLGKDVGK-SLEVKERPDIGVFVKDLSGYVVHNADDLE 203

  Fly   196 NLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATG-VSGEKVSRMSLVDLAGSERAVK 259
            |:|..|||:|.|.||.||.|||||||:||:.:.:  ::...| |...::.::.|||||||||..|
  Fly   204 NIMRLGNKNRAVGATKMNQESSRSHAIFSITVER--SELGEGDVQHVRMGKLQLVDLAGSERQSK 266

  Fly   260 TGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTV 324
            |.|.|.||||.:.||.||:.||.|||.|.|       |....:|||:|.||.||:|:|||||:||
  Fly   267 TQASGQRLKEATKINLSLSVLGNVISALVD-------GKSTHIPYRNSKLTRLLQDSLGGNSKTV 324

  Fly   325 MVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPV 389
            |.|||||:..||.||:||||||.|||.|.|...:||:|...::|..:.|:..||..|:
  Fly   325 MCATISPADSNYMETISTLRYASRAKNIQNRMHINEEPKDALLRHFQEEIARLRKQLE------- 382

  Fly   390 GDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNA 454
                    |.::|.::...:.||:    :...:|.:..||   |.:::|.|:..:.|........
  Fly   383 --------EGDSLEEEPPSSEEEE----DTADDELEAPLE---IELESSTIQAVEKKPKKKREKT 432

  Fly   455 DPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNG 519
            |....||            .:..:..|.:|         ||.....|.....:..::| :..|.|
  Fly   433 DAEKEEL------------AKRKNEHQKEI---------EHAKTEQETLRNKLVSLEG-KILVGG 475

  Fly   520 SAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDP 584
            ...:||.                                 ||...|::.:.|  |:.|:|.|.:.
  Fly   476 ENLLEKA---------------------------------QTQELLLEQSIA--ELEQHEKSEEA 505

  Fly   585 I-----QTAIARLERQHE----EDKQVALEK------------------QRQEYERQ----FQQL 618
            :     |.|..|::.:..    :|....:.|                  |:||::|:    ::.:
  Fly   506 LKQTLQQKATERIDIEERYSTLQDASTGITKKIHRVMQMLMGVKSELADQQQEHQREKEGIYENI 570

  Fly   619 RNI 621
            |::
  Fly   571 RSL 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	157/358 (44%)
		KISc	6..359	CDD:214526	157/356 (44%)
		Kinesin_assoc	356..468	CDD:292801	22/111 (20%)
		FHA	446..546	CDD:238017	14/99 (14%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	155/351 (44%)
		Kinesin	26..352	CDD:278646	153/344 (44%)
		RILP-like	<437..556	CDD:304877	25/175 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940