DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and pav

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	992	Identity:	221/992 - (22%)
Similarity:	378/992 - (38%)	Gaps:	317/992 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASDKIKVAVRVRPF----NRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS 62
            |.|.:.|..||||.    :...:.:.....:.:..|..:||:..|....:|:  ..:.|.|.|
  Fly    33 ARDPVNVFCRVRPLQSDADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQRE--VQYIFKHVF-- 93

  Fly    63 LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQL 127
             .|:    |:|:.|:..|.:.:::|..:|.|:.:|.||.|||||:|||.|....:||:||..|.|
  Fly    94 -QPD----ATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGNLRHRGIMPRCLDVL 153

  Fly   128 FSAIAN-----------------------------------------------KSTPEL------ 139
            |..|::                                               .|.||:
  Fly   154 FRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSDPEIASQASV 218

  Fly   140 ------------MYKVEVSYMEIYNEKVHDLLDPKPNKQSLK---VREHNVMGPYVDGLSQLAVT 189
                        ||.|.|:|:||||..|:|||:....:::|:   :||......:|.|::::.|.
  Fly   219 EPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANRHMFVHGVTEVEVK 283

  Fly   190 SYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTD-QATGVSGEK----VSRMSLV 249
            :.:|...:...|.|.:.:..|.:||||||||:||::.|.|..|| |...|..::    ||::|||
  Fly   284 TVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQNITVSQLSLV 348

  Fly   250 DLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSG-NDKFVPYRDSVLTWLL 313
            |||||||:.:|...|.||:|..|||.||.||...:..|.:......:| ..|.||||||.:|.:.
  Fly   349 DLAGSERSSRTKNTGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKVPYRDSKITHMF 413

  Fly   314 KDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAK--RIVNHAVVNED----PNARIIREL-R 371
            |:...|..:..|:..|:|..::|:|.:..:::|:..:  :|.....:.:|    |..|...:| :
  Fly   414 KNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQIARATPMKQDLGLTPGRRKANKLFK 478

  Fly   372 HEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWE-------------EKLVKTERIQNE 423
            ..|..|..:     |.|         |:::|...:...:.             |..:|...:.:.
  Fly   479 IAVNNLNEL-----GIP---------EAKDLEVDVGLVYSLGPDFPAYEMDSPEAQIKIRELMHY 529

  Fly   424 RQQALEKMGISVQASGIKVEKNKYYLVNLNAD-----PSLNELLVYYLKDRTLIGGRTISGQQPD 483
            .:|.:||.........||.:..:..|:||:.|     ..|..|...|.::|
  Fly   530 LEQRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQLRTELASLKAVYKQER-------------- 580

  Fly   484 IQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK 548
                                              :.|||:||                 :|...:
  Fly   581 ----------------------------------DRSAALEK-----------------KVRIHE 594

  Fly   549 SN----NTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQ-------- 601
            |:    |.::...|    .|:.:..|..:| .:|.|:           :::||::||
  Fly   595 SSIDVLNNTLSKQE----RQIEELTFKLNE-KENMLT-----------QKEHEKEKQKKKFSSKL 643

  Fly   602 -VALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFR 665
             |..:|.::|:|.:.::.|..|.                         .:||:      :||..|
  Fly   644 AVESDKNKREFELKLREQRVKLQ-------------------------ERMRI------KDEKLR 677

  Fly   666 RSLGQLKTDIMRANSLVQEANFLAEE--MEKKTKFSVTLQIPPANLSPNR-------RRGAFVSE 721
                 |.::|:::..|.......:.|  :.:|.:.:.|.:...:::...|       |.||..:.
  Fly   678 -----LVSNILQSEDLPSLPRSQSSENILNEKDRGAYTARTEESSVPATRTDIYATPRHGAAAAN 737

  Fly   722 PAILVKRTNSGSQIWTMEKLEN-------------------KLIDMREMYQEHKER-VLNGLDED 766
            ..  .:|:.|....|...:..|                   ||.|::|:......: .|...|.|
  Fly   738 NR--HRRSRSAGDKWLEHRAANPVPLGTIMQPYLKNRKSVTKLTDLKELTAHGTTKYCLVSQDAD 800

  Fly   767 -NAKPQDPFYESQENHNLIGVANIFLEVLFHDV-----KLDYHTPI--------ISQQG------ 811
             :...:...|:.    |:|.......:|:|:||     |...|:|.        ||..|
  Fly   801 TDGDVETKLYKG----NVIPTCGGGAQVVFNDVECLKQKSPVHSPTRKRPSNGNISALGGGAVPS 861

  Fly   812 ------EVAGRLQVEIE 822
                  :||.|..:.||
  Fly   862 TVTSAQDVASRCNLGIE 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	127/434 (29%)
		KISc	6..359	CDD:214526	126/432 (29%)
		Kinesin_assoc	356..468	CDD:292801	24/134 (18%)
		FHA	446..546	CDD:238017	14/104 (13%)
		KIF1B	741..786	CDD:289208	11/65 (17%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	126/423 (30%)
		Kinesin	42..452	CDD:278646	124/418 (30%)
		MKLP1_Arf_bdg	735..837	CDD:293148	19/107 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940