DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif14

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_006529793.2	Gene:	Kif14 / 381293	MGIID:	1098226	Length:	1717	Species:	Mus musculus

Alignment Length:	1351	Identity:	408/1351 - (30%)
Similarity:	619/1351 - (45%)	Gaps:	298/1351 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPED 67
            :.::.||||||||::||.......:|....::..:::|      :.||..:|.:|..|:|.:...
Mouse   391 NSQVTVAVRVRPFSKREKTEKASQVVFTNGEEITVEHP------DMKQVYSFIYDVSFWSFDECH 449

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            ..:|||.||::.:...:||.||:|||.|:||||||||||||||||..|..|||||.|:.||:.||
Mouse   450 PGYASQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGLNEEPGIIPRFCEDLFAQIA 514

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPK----PNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            .|.|.|:.|.:|:|:.|:||||:||||..|    ..||.|:.|||.|.||||:|||...|:||.|
Mouse   515 KKQTSEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRAREHPVSGPYVEGLSMNVVSSYSD 579

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEK-----VSRMSLVDLAG 253
            |.:.:..|||.|..|||.||.:|||||:||::|:||..|:.   |.||:     .||::||||||
Mouse   580 IQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEV---VEGEEHDHRITSRINLVDLAG 641

  Fly   254 SERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG 318
            |||.....:.|.|||||.:|||||.|||.|||.|::|:|||:    .|:|||:|.||||||::||
Mouse   642 SERCSTAHSSGQRLKEGVSINKSLLTLGKVISALSEQANGKR----VFIPYRESTLTWLLKESLG 702

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLK- 382
            |||:|.|:||:||:|.|.||||||||||.:|:.|||.|.||||.||::||||:.|:|.|::..:
Mouse   703 GNSKTAMIATVSPAASNIEETLSTLRYATQARLIVNIAKVNEDMNAKLIRELKAEIEKLKAAQRS 767

  Fly   383 ---------HATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS 438
                     ......:..::.||.:.|..|.:|.:.|:||..:.|:.:.:..:.|:|.|::.|
Mouse   768 NRNIDPERYRLCRQEITSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKELQKAGVTFQ-- 830

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDS 503
               ::.:...|||||.||.|:|:|:|.:|:.....|:.......||||||:.|..:||.|.....
Mouse   831 ---MDNHLPNLVNLNEDPQLSEMLLYMVKEGVTTVGKHTPSSSHDIQLSGVLIADDHCTIRNFGG 892

  Fly   504 GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP---------KSNNTSMCASEP 559
            .:.:.|...|:.:|||:...|.|.|.:|||::.|..|:||.|.|         .|.|....:..|
Mouse   893 TVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKLSSRNNLTTSEGP 957

  Fly   560 QTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHE--EDKQVALEKQRQE-------YERQF 615
            :      |:.||::|::..:.|....:...|:|:.:.|  :..|:|.|..:||       |||:.
Mouse   958 K------DFEFAKNELLTAQRSRLEAEIKDAQLKAKEEMMQGIQIAKEMAQQELSSQKAVYERKI 1016

  Fly   616 QQLRNILSPST---------------------------PYAPYAPYDPLRMGKITPNTPTSQMRV 653
            |.|...|...:                           ....|.....|.|..:.........|:
Mouse  1017 QALEAELREESQRKRLEELNNQKASHKIEELERAKQHLEQEVYVNKRRLEMETLATKQALEDHRI 1081

  Fly   654 -------------EKWAQE----------RDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKK 695
                         :|.|:|          ||:.|..   |...:.|:.::::||||.::::.:|.
Mouse  1082 RHARILEALEIEKQKIAEEVQMLQENRGNRDKTFTI---QPNWNSMKLSTMIQEANAISDKFKKC 1143

  Fly   696 TKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSG-SQIWTMEKLENKLIDMREMYQEHKERV 759
            ..|.       .:.:.::.|    |:.::.|:....| |..|::||.|:||..|:|:|:.
Mouse  1144 YIFG-------RHDASDKGR----SDTSVRVRNLQLGISTFWSLEKFESKLAAMKELYES----- 1192

  Fly   760 LNGLDEDNAKPQDPFYESQENHNLIGVANIF------------LEVLFHDVKLDYHTPIISQQGE 812
             ||.|.|.....||..|.:.:.....|:::.            :....||:.     ||.|.|..
Mouse  1193 -NGGDRDEDVFCDPADEWEPDITSTPVSSLSRRRSRSLMKNRRVSGCLHDIH-----PIQSMQSS 1251

  Fly   813 VAGRLQVEIERIAGQMPQD---RMCESVSESS----GDSRDEYDDPVDPTSNQITCRVTIKCASG 870
            .:..|..:...|.....:.   .:|:.:..||    |.|.||.....|...|.:
Mouse  1252 HSSGLMEKPSTIYSNSSESFLPGICKELIGSSIDFLGQSFDEEKTIADSLINNL----------- 1305

  Fly   871 LPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALS 935
              |.|.|.|.                 |.|.||::    :.|.:||
Mouse  1306 --LRLHNGVI-----------------AISKAHEE----QDEESQD------------------- 1328

  Fly   936 IEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSP------VE 994
             .::..|:|             ||....:...:.:|....:.|:        |::.|      :|
Mouse  1329 -NLFSDRAA-------------QALTIQVACAFEQLVVLFKHWL--------GDFLPCTGSARLE 1371

  Fly   995 VTNRNEV-LTGGIYQL-RQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRL----QR 1053
            ...|.:: ..||..|| .||....::..||..||. .:.||.|::..|...:|...|:|    ..
Mouse  1372 DELRQDIKKLGGYLQLFLQGCCSDISSMVKEAQNK-VMKIIQQAVQCVGQLAVLKGSKLCVLENS 1435

  Fly  1054 PLDSYQEEDLTVLREKWSEALGRRRQYLDQQI-------QMLIKKEEKNEQERERELSLVHQWVS 1111
            ...|..:|.:..|::..:..:   :..||..:       |.|.::..:.|..::.:.|.| :||.
Mouse  1436 SKVSSTQEFMAALQDGVTSGM---KSLLDSGLETAQDLRQDLSRQSAREEVTKQMKASTV-EWVG 1496

  Fly  1112 LTEERNAVLVPAPGSGIPGAPASWEPPS-------GMEPHVPVL------FLNLNGDDLSAQNTN 1163
            ..|  |||             |.|...|       |....|..|      ||.|.    |.....
Mouse  1497 SLE--NAV-------------AEWRTKSFRTQAQEGSRQQVSKLLSLASEFLKLK----SCLQQT 1542

  Fly  1164 DELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVA---SWDSSMHDSQA 1211
            .|:.|:.:....|..|        .|:...:.:|.:|   ..|.|.|.:.|
Mouse  1543 VEMIVSALRGCPSDLH--------CLRSCTETICSLARKLHSDFSAHSASA 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	188/363 (52%)
		KISc	6..359	CDD:214526	188/361 (52%)
		Kinesin_assoc	356..468	CDD:292801	38/121 (31%)
		FHA	446..546	CDD:238017	38/99 (38%)
		KIF1B	741..786	CDD:289208	13/44 (30%)
		DUF3694	<1196..1252	CDD:289256	6/19 (32%)
		CAP_GLY	1786..1850	CDD:279625
Kif14	XP_006529793.2	AF-4	<161..>384	CDD:368289
		KISc_KIF1A_KIF1B	392..743	CDD:276816	188/363 (52%)
		Kinesin_assoc	740..859	CDD:374417	39/123 (32%)
		FHA	838..935	CDD:238017	38/96 (40%)
		SMC_prok_B	<937..>1109	CDD:274008	29/177 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920