DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and kif1b

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_009295087.1 Gene:kif1b / 369190 ZFINID:ZDB-GENE-030820-1 Length:1924 Species:Danio rerio


Alignment Length:2016 Identity:547/2016 - (27%)
Similarity:820/2016 - (40%) Gaps:649/2016 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            |:...:||||||||||.||...::|||::|:...|.:.||.     ..|:||||:||:.::| .:
Zfish     1 MSGASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPK-----NPKEPKTFSFDYSYWSHTS 60

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            |:|.:||||..|::.:|:.:|.:||:|||.|||||||||:||||||||.||  .:||||:||::|
Zfish    61 PDDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQEGIIPQLCEEL 125

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |..|.:.:..|:.|.|||:|||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
Zfish   126 FEKINDNNNEEISYSVEVAYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 189

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
Zfish   190 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKISLVDLAGSERA 254

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
Zfish   255 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 319

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..|::|||||||||||||:|..:||:||||||:::|||:.||..|:.:|:.
Zfish   320 GNSRTAMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEVSRLKELLRA 384

  Fly   384 -----------------ATGSPVGDVQD------------------------------------- 394
                             .:||...|:.|                                     
Zfish   385 QGLGDILDIEPMGDDCLGSGSKCDDINDVKTLLSSQTEAMLYRRKAPMGCLTASPSSGSLCSQAG 449

  Fly   395 ----------------------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQA 437
                                  :|.|||.::.::::||||||.|||.|:.||:..|.:||::::.
Zfish   450 LQSVSSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIRE 514

  Fly   438 SG------------------IKVE----------------------------KNKYYLVNLNADP 456
            .|                  :.:|                            |...:|||||.||
Zfish   515 DGGTLGVFSPKKFGPDRPTSLSIEDFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDP 579

  Fly   457 SLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-----LYMEPVQGARCF 516
            .::|.|:||:||.....|:..:.::.||.|||..|:.|||:...|.:.     :.:||.:|:..:
Zfish   580 LMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGSETY 644

  Fly   517 VNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM-CASEPQTPAQLIDYNFARDEIMQNE- 579
            |||........|::|:||:.|.:|.||.|.|:...... .....:||.:.:|:.||:.|:::.: 
Zfish   645 VNGKRVNSAVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPVEPVDWTFAQRELLEKQG 709

  Fly   580 -LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMG 640
             .....::..:..:|..::::|:.|   ||:||..||.:.|:|:.               .:...
Zfish   710 IDMKQEMEKRLTEMEILYKKEKEEADQLLEQQRLVYESKLQELQK---------------QVETR 759

  Fly   641 KITPNTPTSQMRVEK-----WAQERDEM----FRR----SLGQLKTDIMRANSLVQEANFLAEEM 692
            .:...||..:...|:     |.|.:.|:    ||:    ....|:..:......::|||.::.|:
Zfish   760 SLAAETPDEEEEEEEEDEVPWTQHKYELAQWAFRKWRYHQFTSLRDQLWGNAVYLKEANAISVEL 824

  Fly   693 EKKTKFSVTL-------QIPPANL--SPNRRRGAFVSEPAILVKRT----NSGSQIWTMEKLENK 744
            :||.:|...|       .:||..|  .|.:.|.|......::....    |..:..|::|||:.:
Zfish   825 KKKVQFQFVLLTDTLYSPLPPELLPPEPEKERDARPFPRTVVAVEVQDLKNGATHYWSLEKLKQR 889

  Fly   745 LIDMREMYQ-----------EHKERVLNGLD---------------------------------- 764
            |..|||||.           :..|..|.|.|                                  
Zfish   890 LDQMREMYDRAGEMASSNQGDDGEGALTGSDPFYDRFHWFKLVGSSPIFHGCVNERLADRTPSPT 954

  Fly   765 -----------------------EDNA-------------------KPQDPFYESQENHNLIGVA 787
                                   :|.|                   ..|||||:......|:|.|
Zfish   955 FSTTDSEITELADERQSEMEDFMDDEAFVDDTSSDAGTEEGSDIFSDGQDPFYDRSPWFILVGRA 1019

  Fly   788 NIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG-------------------------- 826
            .::|..|.:.|.|.:...:::::|:|.|.|:|.::.||.                          
Zfish  1020 FVYLSNLLYPVPLVHRVAVVTEKGDVRGFLRVGVQAIAADEEAPDYGSGVRQSGTAKISFDNEYF 1084

  Fly   827 ---------------QMPQDRMCESVSESS--------------------------GDSRDEYDD 850
                           .:.:.|:.|...:||                          ||...|:.:
Zfish  1085 KKNDFTSVAMTRSGLSLEELRIVEGQGQSSEVITPSEEMNRINEMDLKLGNVDTKLGDGLAEHLE 1149

  Fly   851 PVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQ 915
                ..:..|.|||:..|||:|...:: :|||:.|....:........::|.  :.....|.|.|
Zfish  1150 ----VGSIFTFRVTVLQASGIPAEYAD-IFCQFNFLHRHDEAFSTEPLKNTG--RGAPLGFYHVQ 1207

  Fly   916 DFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELS-----RKI 975
            :.:|.:.|.|:|:.....:..||:||.........|.:|......:|........||     |||
Zfish  1208 NISVEVTESFIEYIKTKPIVFEVFGHYQQHPLHIHGQDVVSPSQPSRKYYPPPMPLSKPDHARKI 1272

  Fly   976 EL--------------------------------------------------------------- 977
            ||                                                               
Zfish  1273 ELIRYLMSGYVHGQVLDTLSEHANALASTAVASLEEGAYELCHFPFLPIPNCPVFRVPRHDVPAT 1337

  Fly   978 ---------------------WVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRV 1021
                                 |.||.||...|||.|..|.:...:...|.|.|.||.|||:.|  
Zfish  1338 KLNTITKSNLGQCVSKYDLLAWFEISELEPTGEYIPAVVDHTGGLPCHGTYLLHQGIQRRITV-- 1400

  Fly  1022 KPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLDQQIQ 1086
                                                      |::.||.||...:       .::
Zfish  1401 ------------------------------------------TLIHEKGSELHWK-------DVR 1416

  Fly  1087 MLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLN 1151
            .|:....:|:.|                             :..:.|.           .||.||
Zfish  1417 ELVVGRIRNKPE-----------------------------VDDSAAD-----------AVLSLN 1441

  Fly  1152 LNGDDLSAQN--TNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNR 1214
            :    :||:|  ::...|...|:|.:|:    .||..:            |.||||:|:|..|||
Zfish  1442 I----ISAKNLKSSHNSSSLCIDSDISR----TFYRFE------------AVWDSSLHNSLLLNR 1486

  Fly  1215 VTEANERVYLILRTTVRLSH---PAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSG 1276
            ||...|::|:.|...:.|.|   ||    ::.|.:.:      ....|..|....|....::.||
Zfish  1487 VTPYGEKIYMTLSAYLELDHCIQPA----IITKDICM------VFYSRDAKISPPRSLRNLFGSG 1541

  Fly  1277 VTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVA 1341
            .:.....|......||    ||.::|.:|     |.|   :::..|.|  :::.:...|..:|:|
Zfish  1542 YSKTPDCNKVTGVYEL----SLCKIADTG-----SPG---MQRRRRKV--LDTSVAYVRGEENLA 1592

  Fly  1342 VKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPA 1406
            ...   ..|..|.:.....:....|:...:.:...||               |..|.   |.:|.
Zfish  1593 GWR---PRGDSLILEHQWELDKMEQLHEVEKTRHLLL---------------LREKL---GETPP 1636

  Fly  1407 GAGGVIRSRHSFGGKGSSDD-SPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYS 1470
                         .|..|:. ||..:.|..|.:||....:..||...       ::.......|.
Zfish  1637 -------------PKSLSESLSPSLSSGTLSTSTSISSQISSTTFES-------AITPSESSGYD 1681

  Fly  1471 DSEYAAEYEQERQQNKSMATRSRLTASKTMDS-------------FMDVSSHSNQSYLSYTSSAN 1522
            .::..:..::|    |.:||:.....:.|.:|             |.|:|.......:|..|||.
Zfish  1682 STDIESLVDRE----KELATKCLRLLTHTFNSEYNQMCNSISDCKFSDISPMGRDPSVSSFSSAT 1742

  Fly  1523 ANMKHLTGLATL-SMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNS----NSPP 1582
                 ||..:|. |:|.|.:....|:|.|   .|..|..:...:.|.||....|...    |..|
Zfish  1743 -----LTPSSTCPSLSDSRTPEANSRATS---PSGSDYENFPMVPILETSYLARAGKHEFLNLVP 1799

  Fly  1583 N 1583
            |
Zfish  1800 N 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 219/361 (61%)
KISc 6..359 CDD:214526 219/359 (61%)
Kinesin_assoc 356..468 CDD:292801 52/233 (22%)
FHA 446..546 CDD:238017 38/104 (37%)
KIF1B 741..786 CDD:289208 19/131 (15%)
DUF3694 <1196..1252 CDD:289256 20/58 (34%)
CAP_GLY 1786..1850 CDD:279625
kif1bXP_009295087.1 KISc_KIF1A_KIF1B 4..360 CDD:276816 219/361 (61%)
KISc 5..360 CDD:214526 219/360 (61%)
Kinesin_assoc 357..593 CDD:292801 54/235 (23%)
FHA 570..674 CDD:238017 38/103 (37%)
FHA <580..672 CDD:224630 30/91 (33%)
GBP_C <677..751 CDD:303769 15/73 (21%)
KIF1B 886..934 CDD:289208 11/47 (23%)
DUF3694 1417..1526 CDD:289256 38/178 (21%)
PH_KIFIA_KIFIB 1805..1907 CDD:269939
PH 1810..1903 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.850

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