DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and Kif1a

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_038940678.1 Gene:Kif1a / 363288 RGDID:1304996 Length:1800 Species:Rattus norvegicus


Alignment Length:2037 Identity:579/2037 - (28%)
Similarity:846/2037 - (41%) Gaps:671/2037 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||:..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
  Rat     1 MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            |||.|:|||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
  Rat    62 PEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.|.:.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
  Rat   127 FSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYN 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||:::.||...|..|.::.||||::|||||||||||
  Rat   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG----KKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..:|    ||.....|:|||||||||||::|||
  Rat   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH 383
            |||||.|||.:||:..||:|||||||||||||:|..:|::|||||.::||||:.||..||.:| :
  Rat   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLL-Y 384

  Fly   384 ATGSPVGDVQD---------------------------------------------------KLA 397
            |.|  :||:.|                                                   :|.
  Rat   385 AQG--LGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLK 447

  Fly   398 ESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS----GIKVEKNKYYLVNLNADPSL 458
            |:|.::.::::||||||.:||.|:.||:..|.:||::::..    |:...|...:|||||.||.:
  Rat   448 ETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLM 512

  Fly   459 NELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-----LYMEPVQGARCFVN 518
            :|.|:||:||.....||..:.::.||.|||..|:.|||:...:..|     :.:||.:||..:||
  Rat   513 SECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVN 577

  Fly   519 GSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSMCASEPQTPAQLIDYNFARDEIMQNE 579
            |....|.:.|::|:||:.|..|.||.|.|    :....:.||   :|||:.:|:.||:.|:::.:
  Rat   578 GKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCA---ETPAEPVDWAFAQRELLEKQ 639

  Fly   580 --LSNDPIQTAIARLERQHEEDKQVA---LEKQRQEYERQFQQLRNILS----PSTPYAPYAPYD 635
              .....::..:..||.|:..:::.|   ||:||.:||.:.:.|:..:.    |........|.|
  Rat   640 GIDMKQEMEQRLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPED 704

  Fly   636 PLRMGKITPNTPTSQMRVEKWAQERDEM----FRR-------SLGQLKTDIMRANSL-VQEANFL 688
            .:                 :|.:...|:    ||:       ||    .|::..|:: ::|||.:
  Rat   705 EV-----------------QWTERECELALWAFRKWKWYQFTSL----RDLLWGNAIFLKEANAI 748

  Fly   689 AEEMEKKTKFSVTL-------QIPPANLSP----NRRRGAFVSEPAILV-----KRTNSGSQIWT 737
            :.|::||.:|...|       .:||..|.|    :|....|   |..:|     .:.|..:..||
  Rat   749 SVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPF---PRTIVAVEVQDQKNGATHYWT 810

  Fly   738 MEKLENKLIDMREMYQEHKE-------------------------------RVLNGL-------- 763
            :|||..:|..|||||....|                               .|::|.        
  Rat   811 LEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGSSVISGCNSYPLLNT 875

  Fly   764 ------------------DEDNAKP--------------------------------------QD 772
                              |.|..:|                                      ||
  Rat   876 CMSERMAALTPSPTFSSPDSDTTEPAEEQSVGEEEEEEEEEEEEEEEEDLEDDVFPEHTLCDGQD 940

  Fly   773 PFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG--QMP------ 829
            |||:.....:|:|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.|:.  :.|      
  Rat   941 PFYDRPPLFSLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGV 1005

  Fly   830 ------------------QDRMCESVSES-SGDSRDE---------------------------- 847
                              |...|..|..| ||.|::|                            
  Rat  1006 RQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAV 1070

  Fly   848 -------------YDDPVDPTSNQI------TCRVTIKCASGLPLSLSNFVFCQYTF-WGHQEMV 892
                         .|.|:|...:.:      |.|||:..||.:....:: :|||:.| ..|.|  
  Rat  1071 PPEGLLDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYAD-IFCQFNFIHRHDE-- 1132

  Fly   893 VPVINAESTAHDQNM----VFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWE 953
                 |.||...:|.    ...|.|.|:..|.:.:.|:|:.....:..||:||...........:
  Rat  1133 -----AFSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKD 1192

  Fly   954 VEQQQAKARSLVDRWAELSRKIE----------------------LWVEIHELNDNGEYSPVEVT 996
            |......:|....|...||:.:.                      ::.||.||..||:|.|..|.
  Rat  1193 VLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVD 1257

  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEE 1061
            :|..:...|.:.|.||.|||:.|                                          
  Rat  1258 HRGGMPCMGTFLLHQGIQRRITV------------------------------------------ 1280

  Fly  1062 DLTVLRE-----KWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLV 1121
              |:|.|     :|.|            ::.|:....:|..|.:..|                  
  Rat  1281 --TLLHETGSHIRWKE------------VRELVVGRIRNTPETDEAL------------------ 1313

  Fly  1122 PAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTL 1186
                               ::|::    |:||                    |||..:.|.  ..
  Rat  1314 -------------------IDPNI----LSLN--------------------ILSSGYVHP--AQ 1333

  Fly  1187 QILQHLDKDVCCV-----ASWDSSMHDSQALNRVTEANERVYLILRTTVRL---SHPAPMDLVLR 1243
            ...|.||.|:...     |:||||||:|..|||||...|::|:.|...:.:   :.||    |:.
  Rat  1334 DDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPA----VIT 1394

  Fly  1244 KRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGD-- 1306
            |...:      ....|..|....|....::.||.......|......||    ||..:|.:|.  
  Rat  1395 KDFCM------VFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYEL----SLCHVADAGSPG 1449

  Fly  1307 ---------DCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVK----ELETAHGQPLSMRKT 1358
                     |.|.:        |.||    |..|...|.|.:..:.    |||     .||:.:.
  Rat  1450 MQRRRRRVLDTSVA--------YVRG----EENLAGWRPRSDSLILDHQWELE-----KLSLLQE 1497

  Fly  1359 VSVPNFSQIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGS 1423
            |.......::|     |.|....|.               .|...|||                |
  Rat  1498 VEKTRHYLLLR-----EKLETTQRP---------------VPEVLSPA----------------S 1526

  Fly  1424 SDDSPGKAFGIASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSM 1488
            |:||..::   :|.|:|.|                 |.:.:|.        ..|...|||:..::
  Rat  1527 SEDSESRS---SSGASSPL-----------------SAEGQPS--------PLEVPNERQRELAV 1563

  Fly  1489 A-------------TRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSST 1540
            .             |.|.:..|         :|.|..|.:|.|...:.:|..| |.|||:.||:.
  Rat  1564 KCLRLLMHTFNREYTHSHVCIS---------ASESKLSEMSVTLMRDPSMSPL-GAATLTPSSTC 1618

  Fly  1541 SS----GYGSQAV----SCNNLSNEDIASMRSMSIDETPDFDRVNSNS--------PPNRQARVN 1589
            .|    .||:..|    .|:..::.:...:..:...:||...|.....        |..::.||:
  Rat  1619 PSLIEGRYGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVS 1683

  Fly  1590 P------------------------------------------FLKDMPKAKIQEQPEQQAK-KL 1611
            |                                          |:.::..|:::...:|||. |.
  Rat  1684 PIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKT 1748

  Fly  1612 QEAFTHPLEQLESSQNAQSDDD 1633
            ...|....|.......|.||.|
  Rat  1749 PNTFAVCTEHRGILLQANSDKD 1770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 219/361 (61%)
KISc 6..359 CDD:214526 219/359 (61%)
Kinesin_assoc 356..468 CDD:292801 50/166 (30%)
FHA 446..546 CDD:238017 41/104 (39%)
KIF1B 741..786 CDD:289208 19/139 (14%)
DUF3694 <1196..1252 CDD:289256 20/63 (32%)
CAP_GLY 1786..1850 CDD:279625
Kif1aXP_038940678.1 KISc_KIF1A_KIF1B 4..361 CDD:276816 219/361 (61%)
Kinesin_assoc 358..524 CDD:406567 52/168 (31%)
FHA 501..605 CDD:238017 41/103 (40%)
KIF1B 814..861 CDD:403579 8/46 (17%)
DUF3694 1250..1406 CDD:403614 54/284 (19%)
PH_KIFIA_KIFIB 1681..1783 CDD:269939 15/90 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100247
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.820

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