DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc-73 and Cenpe

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_038959788.1 Gene:Cenpe / 362044 RGDID:1307115 Length:2456 Species:Rattus norvegicus


Alignment Length:2011 Identity:431/2011 - (21%)
Similarity:777/2011 - (38%) Gaps:531/2011 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKVAVRVRPFNRREIEL-DTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            :.|.|||||.|.||.|| :...|.....:..|.|:         ...|:|.||..|:| |...:|
  Rat     7 VAVCVRVRPLNSREEELGEASHIYWKTDKNAIYQS---------DGGKSFQFDRVFHS-NETTKN 61

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANK 134
                  |::.:...|:.:|.||||..|||||||.|||::||||:::..|:|||....:|..|  |
  Rat    62 ------VYEEIAVPIISSAIQGYNGTIFAYGQTASGKTHTMMGSEDCLGVIPRAIHDIFQRI--K 118

  Fly   135 STPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMT 199
            ..||..:.:.|||||||||.:.|||......:.|.:||......||..|::..|.:.:.....:.
  Rat   119 KFPEREFLLRVSYMEIYNETITDLLCNTQKVKPLIIREDINRNVYVADLTEEVVYTAEMALKWLA 183

  Fly   200 EGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMSLVDLAGSERAVKTGAV 263
            .|.|:|....|.||..|||||.:|.::|......:::...|. |||.::||||||||||.:|||.
  Rat   184 TGEKNRHYGITKMNQRSSRSHTIFRMILESREKAESSNCDGSIKVSHLNLVDLAGSERAAQTGAE 248

  Fly   264 GDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVAT 328
            |.|||||..||::|..||.||.||:|   |:..|   |:.||||.||.:|:::||||::|.::.|
  Rat   249 GMRLKEGCYINRNLLILGQVIKKLSD---GQVGG---FINYRDSKLTRILQNSLGGNAKTRIICT 307

  Fly   329 ISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPN-ARIIRELRHEVETLRSMLKHATGSPVGDV 392
            |:|:  :.:|||:||::|..||.:.|...|||..| ..:::..|.|:..|:..|:        :|
  Rat   308 ITPA--SLDETLTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRREIVDLKKQLE--------EV 362

  Fly   393 QDKLAESENLMKQISQTWEEK----LVKTERIQNERQQALEKMGISVQAS-GIKVEKNKYYLVNL 452
            ..|....|....|::|..:||    .|:.|:|||.::..:....|::|.. .||.::...:....
  Rat   363 NTKTRAQEIEKDQLAQLLDEKDLLQKVQDEKIQNLKRMLVTSSSIALQQELEIKKKRRVTWCFGK 427

  Fly   453 NADPSLNELLVYYLKD---RTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGAR 514
            ..|.:       |:|:   .|.|..||.......::        |:.::.:.:|.|..|    :.
  Rat   428 MKDSN-------YVKEFKIPTNITTRTRKTSVTPLR--------ENSLMKLGESALSWE----SE 473

  Fly   515 CFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNE 579
            .|.|....:.:....:...:|          |.::..:.:.:...|....::||...|.|     
  Rat   474 VFDNTLEPLAEAEWSSATALL----------SEENLESELTSLNTQYNNLVLDYEQLRRE----- 523

  Fly   580 LSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQ------QLRNILSPSTPYAPYAPYDPLR 638
              |:.::   .:|:.::|.::...|| ||:|.:::.|      .|:|::..:..|          
  Rat   524 --NEDLK---LKLKEKNELEEFEFLE-QREEKDQELQLMHEVSNLKNLIKHAEEY---------- 572

  Fly   639 MGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQ 703
             .:...|..:|::.:.|..:::.:..:|.:     |..::.:...:.::.:|..|...:...||.
  Rat   573 -NQDLENELSSKVELLKEKEDQIKELQRYI-----DAQKSETTKTDLSYSSEATEDLKQAMRTLS 631

  Fly   704 IPPANLSPNRRRGAFV-SEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQ---EHKERVLNGLD 764
            .........:|..||: ||...|.:|.|..|.  :.:::||.:    :|||   |.|::|...|:
  Rat   632 DLDTVALDAKRESAFLRSENLELKERINELSD--SCKQMENGI----QMYQRQLEAKKQVQADLE 690

  Fly   765 EDNAKPQDPFYESQENHNLIG----VANIFLEVLFHDVKLDYHTPI------------------- 806
            ::   .|..|.|..:...|:.    ::|:.||....|::.:.:..:                   
  Rat   691 KE---LQLAFQEISKLSALVDGKGLLSNLELEKRITDLQKELNKEVEEKETLQKEVHLLSELKSL 752

  Fly   807 ----------ISQQGEVAGRLQVEIERIAGQMP-QDRMCESVSESSGDSRDEYDDPVDPTSNQIT 860
                      :.::.|....:..|.|::..:|. :|...:.:.|..|:::|      |..::|::
  Rat   753 PSEVETLRRELHEKSEELCVITTEREKLFSEMAHKDSRIQGLLEEIGNTKD------DLAASQLS 811

  Fly   861 CRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEF 925
            .|             |:...||.....|.|:                    :|.|       ||.
  Rat   812 QR-------------SSDEECQALKSLHVEL--------------------KHRQ-------EEV 836

  Fly   926 LEHC--IEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNG 988
            ||..  ::..||           .||:  |:.|:.|:.:.::::..||..|:       |..|:.
  Rat   837 LEESERVKQELS-----------QKTQ--ELAQKTAEGQEMLNQMEELREKL-------ERRDSS 881

  Fly   989 EYSPVEVTN-RNEVLTGGIYQLRQGQQRRVNVRVKPVQNS-----GTLPIICQSIVNVAIGSVTV 1047
            ..|..:..| ..|.|...:.::|...|.:.:  :|.:|.|     ..|....|..||:   ::..
  Rat   882 LQSAEKEKNLLTEKLQQTLEEVRALTQEKND--LKQLQESLQTERDQLRSDIQDTVNM---NIDT 941

  Fly  1048 RSRLQRPLDSYQ--EEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWV 1110
            :.:|...|:|.:  :|.:.:|:.|.:|         :....:.||..|.:..|.|::|..:.:..
  Rat   942 QEQLLNALESLKQHQETINMLKMKATE---------EMSDHLPIKGREGSSDEVEQKLDGIDEEN 997

  Fly  1111 SLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSIL 1175
            .|.|..:.|:    |||                                                
  Rat   998 LLAESAHTVV----GSG------------------------------------------------ 1010

  Fly  1176 SKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDL 1240
             ::||                        ...:.:.::.:.:.|.|:...|.:.:.......|||
  Rat  1011 -EDHG------------------------ETEEQRKIDSLLQENSRLQQTLESIIAEKEQLKMDL 1050

  Fly  1241 VLRKRLSI-NIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEEL-EDRESLAQL-- 1301
            .....:|: |.::.:.|.|.||:           |..:..:...::.:.|||| ...|.||::  
  Rat  1051 KENIEMSVENQEELRILRDELKR-----------QQEIAAQEKDHVTEKSEELSRAHERLAEIEE 1104

  Fly  1302 ---------------------AASGDDCSASDGETYIEKYTRGVSAVESILT-----LDRLRQNV 1340
                                 |.|......:|.|....::.....|:|.:.|     ..:|.:|.
  Rat  1105 KLKEKNQKLQETQQQLVSIQEAMSEMQAKVTDLENLQNEFRNQALALERVETERLELAQKLHENY 1169

  Fly  1341 AVKELETAHGQPL-SMRKTVSVPNFSQIMRFDASMESL-------LNVGR--------------- 1382
            ...|..|.....| .::::..:.. .|:..:...|||.       ||:..               
  Rat  1170 EKMESITKERNDLKELQESFEIEK-KQLKEYAREMESAGLQTKEQLNIAHANLKEYQEIIKELRG 1233

  Fly  1383 --SESFADLNNSALGNKFTPA--GHSP-----------------AGAGGVI-------RSRHSFG 1419
              ||..|..:::....|..||  |.:|                 |..|..:       |:.||..
  Rat  1234 SISEKEAQASSTQDTGKTNPASQGETPVPREQELLPDAEEARASAEKGSELEPVEEHSRTAHSLT 1298

  Fly  1420 GKG----------SSDDSPGKAFGIASP-----ATSKLLGMRMTTLHEE---PLGGHRSLDEE-- 1464
            .:|          ..::|..:...:...     .|.:.|.:....|.::   .|..|...:||  
  Rat  1299 TEGIEMEILALTKKLEESQKEISCLTKERSDLRRTQEALQVECAQLKDDARRTLANHLETEEELS 1363

  Fly  1465 -------PEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSAN 1522
                   .:::..|| ......|:..:..|:..:..:|..:......::.....|..:..||...
  Rat  1364 LARCCLKEQENKIDS-LIVSLSQKEAELSSVRVQLEVTTGELERKVQELCEKQEQLNIKETSEVQ 1427

  Fly  1523 ANMKHLTGLATLSMSSSTSSGYGSQAVSCNNL--------SNEDIASMRSMSIDETPDFDRVNSN 1579
            ..|..|..:..|.::..::    .|:|..:.|        |.|:|    .:.|.|..:..|....
  Rat  1428 GKMSELDHIRALLLTKDSA----LQSVESDRLRLNKQLEESQEEI----KILIKEREELRRAQEA 1484

  Fly  1580 SPPNRQARVNPFLKDMPKAKIQEQPEQQ-----AKKLQEAFTHPLEQLESSQNAQSDDDECAQLP 1639
            ....|:.: ...:|:: ..::||..:::     .|.|.|...:..|.|.....||....|..:: 
  Rat  1485 LHVEREQQ-QESIKEI-STRLQELQDKEYEYLVMKSLNETQGNKCEDLNQQLEAQKSSLEKVEM- 1546

  Fly  1640 KNNNNNL-----DLVNEPKPLSSQTD-------------------LEESMSQPKSKTE------- 1673
              .|.||     :.:.|.|.::.:.|                   |||::::...|.|       
  Rat  1547 --QNVNLTQRLNETLEEMKSVAKERDELRSVEERLTADRDQLKKSLEETITKGLEKEEELRVAHM 1609

  Fly  1674 FATDNQ---NGNRSS-----DELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINN 1730
            ...::|   |..|.|     ||::|...||.....::..:|      ....:|.:....|:.::.
  Rat  1610 HLQEHQETINELRKSVSDCTDEIAHIHGDLEHTHAVIHGDL------EHTHANQELQEKGHQLSQ 1668

  Fly  1731 NNNGTTQAPRINHRASVAKMEGLAAYLDSSIMT-SSTEVD---------EESKDVELVLPE 1781
                    .:.:.|.::.:||.|...|::...| .|.|::         |..|::.||..|
  Rat  1669 --------VKADLRETMDQMEQLKEQLEAQNSTLESIEIEKLKLTQQLNENLKEMTLVAKE 1721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 144/354 (41%)
KISc 6..359 CDD:214526 144/354 (41%)
Kinesin_assoc 356..468 CDD:292801 26/117 (22%)
FHA 446..546 CDD:238017 14/102 (14%)
KIF1B 741..786 CDD:289208 13/51 (25%)
DUF3694 <1196..1252 CDD:289256 8/56 (14%)
CAP_GLY 1786..1850 CDD:279625
CenpeXP_038959788.1 KISc_CENP_E 6..329 CDD:276825 143/347 (41%)
Smc <334..1057 CDD:224117 165/952 (17%)
Smc 787..1603 CDD:224117 166/998 (17%)
Smc 1320..2167 CDD:224117 75/430 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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