DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and neb

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster

Alignment Length:	1036	Identity:	329/1036 - (31%)
Similarity:	501/1036 - (48%)	Gaps:	197/1036 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VAVRVRPFNRREI---ELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            |||||||.|..|.   ::.....|.....:..:|.....: ........|::|..:||.:||.:|
  Fly   123 VAVRVRPLNALECTRGQVTNVVQVHGNSNELTVQAGSSAD-ASAGVTHFFSYDQVYYSCDPERKN 186

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ-------------ESKGIIP 121
            ||.|..||:...|.::|.||:|||||:||||||||||||:|||.:             :..||||
  Fly   187 FACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEALDDAALDGGPPHDEAGIIP 251

  Fly   122 RLCDQLFSAI-ANKSTPELMYKVEVSYMEIYNEKVHDLL----------DPKPNKQ-------SL 168
            |.|.:||..| |.||..:|..:|||||.||||||:||||          :..|.:|       :|
  Fly   252 RFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQQQQQQQRPAL 316

  Fly   169 KVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTD 233
            |||||.:.||||..||..:|.||..:.|.:..||..|..|:|.||.:|||||::|::||.  |||
  Fly   317 KVREHPIFGPYVVDLSAHSVDSYSALRNWLAVGNSQRATASTAMNDKSSRSHSIFNIVLN--LTD 379

  Fly   234 QAT--GVSGE------------KVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVI 284
            .::  |:|.:            :.|::||||||||||...:|:.|:|::||.:|||||.|||.||
  Fly   380 LSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGSNGERIREGVSINKSLLTLGKVI 444

  Fly   285 SKLADQ----SNGK-KSGN-DKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTL 343
            :.|||.    :||. .||. ..|||||:|||||||::||||||:|||:|||||::.:.:|||:||
  Fly   445 AALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTVMLATISPASIHADETLATL 509

  Fly   344 RYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM---------LKHATGSP----------- 388
            |||.:|:.|||...|||.|:.:|||:||.||:.|:|:         |...:.:|
  Fly   510 RYACKARSIVNRVKVNESPHDKIIRDLRAEVDRLKSLRNEYERQRRLSGNSNNPVPRKIIIETSV 574

  Fly   389 ----VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYL 449
                |..::.:|||.|..:.:..::|.|||.:.|..:....:.|::.|::::   :..|:.:..|
  Fly   575 DETEVEALRQQLAERERELSRAQKSWMEKLKEAEDQRKSELRVLKRRGLALE---LTAEQKQACL 636

  Fly   450 VNLNADPSLNELLVYYLKDRTLIGGR-----TISGQQPDIQLSGLGIQPEHCVITIEDSG-LYME 508
            |||.|||.|:..|.|.|....:..||     ..|..||||.|.|..:..:||.|..|..| ||:.
  Fly   637 VNLTADPILSGTLFYLLPQGLVRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHERGGKLYVI 701

  Fly   509 P-VQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFAR 572
            | .:....:|||....::..|.:|||::.|..|:||:::|..:.... |..|      :|:..|.
  Fly   702 PGSEDFETYVNGELLKDRRQLFHGDRLVIGGSHYFRISNPFCSQRGK-ADHP------VDFQLAH 759

  Fly   573 DEIMQNELSNDPIQTAIARLERQHEEDKQVAL---EKQRQEYERQFQQLRNILS----------- 623
            .||:|.:..         :|..:.|.:|:.||   |::|.::.|.|::....|.
  Fly   760 QEILQKQEQ---------QLRSELEAEKRAALTKIEQERAQHARDFEERLQCLELEQFKYKCNSE 815

  Fly   624 ------PSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLV 682
                  .:...|....:.||| .:...:||..:..:      .:::.|..|...:..:.:...:|
  Fly   816 MLETERQALALAQQQEHTPLR-HEDAVSTPAQKSTI------LEDIQRIMLNPSEESLHKTQLMV 873

  Fly   683 QEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLID 747
            :||.....:::...:|..| |.|.       ..|...:...||.|:....:: |...:|
  Fly   874 KEATQRCRQLDLPLEFRQT-QTPD-------EFGLLRTVILILDKQRGLKAE-WPTARL------ 923

  Fly   748 MREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGE 812
                      .|...|..|||       |.||..|        ...:|..|::|:. |:.:...|
  Fly   924 ----------GVWLDLVRDNA-------EQQEKLN--------ATTIFQSVEVDWE-PLDADLNE 962

  Fly   813 V------AGRLQVEIERIAGQM---PQDRMCESVSESSGDSRDEYDDPVDPTSNQI--TCRVTIK 866
            .      :.|:.:.:..:...:   |..|:..:.|..|...| :...| .|.|..:  |.|:...
  Fly   963 TLSDTHNSSRIALNLSAMKDVLLNKPLKRLLNASSSKSNTPR-QTSTP-SPGSQLVHFTKRLLTY 1025

  Fly   867 CASGLPLSLSNFVFCQYTFWGHQEMVVPVINAES-TAHDQNMVFKFEHTQD---FTVTINE 923
            ....:|.|.|:|     |....||:.:...:|:. ..|.:..:.:.|:.||   ..|::.|
  Fly  1026 DPEEIPESQSSF-----TTLVQQELQIMQRSAQRLRRHCEAALLERENHQDNGVLAVSLQE 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	184/404 (46%)
		KISc	6..359	CDD:214526	184/404 (46%)
		Kinesin_assoc	356..468	CDD:292801	39/135 (29%)
		FHA	446..546	CDD:238017	39/106 (37%)
		KIF1B	741..786	CDD:289208	10/44 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	184/404 (46%)
		KISc	120..525	CDD:214526	184/404 (46%)
		Kinesin_assoc	524..657	CDD:292801	39/135 (29%)
		FHA	634..740	CDD:238017	39/105 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437757
Domainoid	1	1.000	252	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D6426at50557
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.950