Protein Alignment Khc-73 and Klp31E

DIOPT Version :9

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_001162935.1
• Gene: Klp31E / 34422
• FlyBaseID: FBgn0032243
• Length: 1048
• Species: Drosophila melanogaster
• Alignment Length: 1132
• Identity: 290/1132 - (25%)
• Similarity: 476/1132 - (42%)
• Gaps: 242/1132 - (21%)

  Fly     6 IKVAVRVRPFNRRE-IELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDEN 69
            ::||||:||.|.|| |::...|       .|:....|   :|.....|.|.||:.|      |.|
  Fly    14 VRVAVRIRPQNSRELIDMCRIC-------TTVTLGEP---QIFLGSDKAFTFDYVF------DTN 62

  Fly    70 FASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT---QESK-------GIIPRLC 124
            ....:...|||.: ::|:...||||.:.|||||||||:|| |||   .||:       |||||..
  Fly    63 SNQCDIYSDCVEK-LVDSTLHGYNATVLAYGQTGSGKTYT-MGTGFDHESESSDSVQLGIIPRAV 125

  Fly   125 DQLFSAI---ANKSTPE-------LMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPY 179
            ..:||.|   ...||.|       ..:.:.|.|:|:|||.:.|||||.....:.|:.|
  Fly   126 RHIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHE------- 183

  Fly   180 VDGLSQLAVTS------YQDIDNL--MTEGNKSRTVAATNMNAESSRSHAVFSV-VLTQILTDQA 235
             |...|:.::.      ||..|.|  :.:|..:||.|:|.||.:||||||:|:: |..|.|...:
  Fly   184 -DASGQITISGASIKPIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPS 247

  Fly   236 TGVSGEKV----SRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKS 296
            ..|....:    |:...||||||||..:|.|.|:|.:||.:||..|..||..||.|.|     ||
  Fly   248 DNVPDNDLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGD-----KS 307

  Fly   297 GNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNED 361
            .....||||||.||.||:|:|||||:|:|:|.:|||..::.|||:||:||:||:.|.|...:|:|
  Fly   308 KRALHVPYRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQD 372

  Fly   362 PNARIIRELRHEVETLR-SMLKHATGSPVGDVQDKLAESENLMKQISQTW-EEKLVKTE--RIQN 422
            .::|.|.:||.|:..|: .:|::..|..:.|.:....        ||.|: |.||:.:|  |:|
  Fly   373 QSSRTISQLRREIAALQLELLEYKQGKLIVDCEGNTT--------ISDTFNENKLLLSEIKRLQ- 428

  Fly   423 ERQQALEKMGISVQASGIKVEKNKYYLVNL---------NADPSLNELLVYYLKDRTLIGGRTIS 478
            :|.::|:....::      .::|.....||         |:|..:.:::..|:.:...:..:.|.
  Fly   429 QRLKSLQSTIATL------TQRNADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIE 487

  Fly   479 GQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFR 543
            .::...|:.          |....|....:||..:.........:|:.......|.|.|    .:
  Fly   488 SEEHRKQME----------IKATTSPRNAKPVYDSDIITKAKKDLERERELLMSRSLPG----IQ 538

  Fly   544 VNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE--RQHEEDKQVAL-- 604
            ..:..|..|.:.:|:.:....:.|.....::|.......:.::...:|.|  |.|.|:|...|
  Fly   539 NQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMRTKLIEQLELTNSRYEQMRTHYEEKLSVLYC 603

  Fly   605 -----EKQRQEYERQFQQLRNI-LSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVE-KWAQERDE 662
                 :|:|.:.      |.|: .|.|||     ..|.|:..|....:..|.|:.| :..|....
  Fly   604 KIENTQKERDDV------LANMTTSVSTP-----SKDSLKKVKTDYESKISHMQTEIRKLQNAQR 657

  Fly   663 MFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVK 727
            ...||..|||:..:|..:|..|.|.|        ||:....:...:...||.:    .|.:   :
  Fly   658 EHIRSKQQLKSHEVRIGTLRNELNEL--------KFAKVKLMKKMSQQSNRHK----QEES---R 707

  Fly   728 RTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDED----------NAKPQDPFYESQENHN 782
            ::...:|:...::.:...:...|.....||::|....|:          .:..:.|.:.:.:...
  Fly   708 KSKEIAQLLKEQRRQKNAVLTLEAKVSAKEQILKRKTEEVIALRKSQRGKSGQRAPAHLTSKIAT 772

  Fly   783 LIGVA---------NIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVS 838
            |.|.:         |::..:| |..:   :..:|:|       |:.|:||:..:. :|...|...
  Fly   773 LDGFSTRSARHRWENLYRNIL-HAAR---NRQLITQ-------LEKELERLILER-EDLSRELNI 825

  Fly   839 ESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAH 903
            ..:|.:.|...|..:...|..|                |..:.|                |:..|
  Fly   826 MENGQTADRQTDEFNEVDNLKT----------------NISYIQ----------------ENIEH 858

  Fly   904 DQNMVFKFEHTQD----------------FTVT----INEEFLEHCIEGALSIEV-WGHRSAGFS 947
            .|..:.:||.|:|                .||.    |.::|.:..|..:.::.: ..|.....|
  Fly   859 VQQAIMEFEDTKDTVQSHVNKIQSLLDEVSTVAEAKFILQKFSDTAIVMSCNLAIAESHLQEKES 923

  Fly   948 KTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGE--YSPVEVTNRNEVLTGGIY--- 1007
            ..|  ||:|:....:.::..:...:..:.:......||..|.  .|.|...::..:::...|
  Fly   924 LLK--EVKQESGIQQQILQHFLSQNSNVHIADIFDSLNLKGSNIASSVNPGSQKSLISNATYDIP 986

  Fly  1008 ------QLRQGQQRRVNVR-VKPVQNS 1027
                  :..|.:.||...| ..|:.||
  Fly   987 QDDKNSEFHQVEMRRTTSRSPSPLGNS 1013

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	152/386 (39%)
		KISc	6..359	CDD:214526	152/386 (39%)
		Kinesin_assoc	356..468	CDD:292801	28/124 (23%)
		FHA	446..546	CDD:238017	15/108 (14%)
		KIF1B	741..786	CDD:289208	7/54 (13%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	150/380 (39%)
		KISc	13..370	CDD:214526	152/386 (39%)
		KASH_CCD	409..589	CDD:291334	33/208 (16%)
		RasGAP	<685..750	CDD:295371	10/71 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437750
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940