DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and Klp10A

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	153/557 - (27%)
Similarity:	244/557 - (43%)	Gaps:	116/557 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREI---ELDTKCIVEMEKQQTILQNPP--PLEKIERKQPKTFAFDHCFYSLN 64
            :|.|.||.||.:|:|:   |:|   ::.:.::..::.:.|  .::..:..:...|.||   |:.|
  Fly   278 QITVCVRKRPISRKEVNRKEID---VISVPRKDMLIVHEPRSKVDLTKFLENHKFRFD---YAFN 336

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG-----TQESK-GIIPRL 123
            ...:|    ..|:....:.::...|:|..|..||||||||||::||.|     .|:.| ||....
  Fly   337 DTCDN----AMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMA 397

  Fly   124 CDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAV 188
            ...:|..:.......:...|..|:.|||:.||.|||.   :||.|:|.|.......|.||::..|
  Fly   398 AKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLS---DKQKLRVLEDGKQQVQVVGLTEKVV 459

  Fly   189 TSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAG 253
            ...:::..|:..||.:||...|:.|:.||||||||.:||.   ...:|.:.|    :.|.:||||
  Fly   460 DGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLR---PQGSTKIHG----KFSFIDLAG 517

  Fly   254 SERAVKTGAVGDRLK-EGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN- 316
            :||.|.|.:...:.: ||:.|||||..|...|..|     ||:|.:   :|:|.|.||.:|:|:
  Fly   518 NERGVDTSSADRQTRMEGAEINKSLLALKECIRAL-----GKQSAH---LPFRVSKLTQVLRDSF 574

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVV----------------NEDPNAR 365
            :|..|:|.|:|.|||...:.|.||:|||||||.|.:|...:|                .|:....
  Fly   575 IGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELN 639

  Fly   366 IIRELRHEV-----------ETLRSMLKHATGSPV--------------------------GDVQ 393
            ::....|::           ...|:...|.:|:.:                          .::.
  Fly   640 MVHPHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMS 704

  Fly   394 DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSL 458
            |:|......:..:.|| ||.:|:..|..|...:..           :...|..|.|.|
  Fly   705 DELIVQHQAIDDLQQT-EEMVVEYHRTVNATLETF-----------LAESKALYNLTN------- 750

  Fly   459 NELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEH 495
               .|.|.:|.....|.::..|..||.:....:..|:
  Fly   751 ---YVDYDQDSYCKRGESMFSQLLDIAIQCRDMMAEY 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	127/382 (33%)
		KISc	6..359	CDD:214526	127/381 (33%)
		Kinesin_assoc	356..468	CDD:292801	21/164 (13%)
		FHA	446..546	CDD:238017	11/50 (22%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	124/357 (35%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	121/352 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437743
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940