DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif16b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_038960967.1	Gene:	Kif16b / 311478	RGDID:	1310146	Length:	1876	Species:	Rattus norvegicus

Alignment Length:	1670	Identity:	462/1670 - (27%)
Similarity:	711/1670 - (42%)	Gaps:	437/1670 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-------RKQPKTFAFDHCFYSLNPEDENFA 71
            |.:::|.:|:.|.|::|||.:|.:.|   |:..|       |::.|||.:|..|||.:.:..::.
  Rat    15 PMSKQEKDLEAKFIIQMEKSKTTITN---LKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYV 76

  Fly    72 SQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKST 136
            ||||||..:|..::.:||:|||||:||||||||||||||||.....|:|||:|:.|||.| |::|
  Rat    77 SQETVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEALFSRI-NETT 140

  Fly   137 --PELMYKVEVSYMEIYNEKVHDLLDPKPNKQ-SLKVREHNVMGPYVDGLSQLAVTSYQDIDNLM 198
              .|..::.||||:|||||:|.|||..|.:|. :|:||||...||||:.||:..|.:|.|::.||
  Rat   141 RWDEASFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELM 205

  Fly   199 TEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAV 263
            ..||.:||.|||.||..||||||:|::..||...|  ..:..|.||::.||||||||||..|||.
  Rat   206 DAGNINRTTAATGMNDVSSRSHAIFTIKFTQAKFD--AEMPCETVSKIHLVDLAGSERADATGAT 268

  Fly   264 GDRLKEGSNINKSLTTLGLVISKLADQS----NGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTV 324
            |.|||||.||||||.|||.|||.|||.|    |........|||||||||||||||:|||||:|:
  Rat   269 GVRLKEGGNINKSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTI 333

  Fly   325 MVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPV 389
            |:|||||:..||.|||||||||:|||.|:|...:|||.|.::|||||.|:..|:::|  |.|:.:
  Rat   334 MIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLL--AQGNQI 396

  Fly   390 G--------DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNK 446
            .        .:::||.::|..::::::.|..|..:|:.|..|:..||.|.||     |:.::...
  Rat   397 ALLDSPTALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGI-----GVVLDSEL 456

  Fly   447 YYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQ 511
            .:|:.::.|.....:::|:||:.....||..:..:.||.|.||.::.||||.......:.:.|:.
  Rat   457 PHLIGIDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENAGGTVTLIPLS 521

  Fly   512 GARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIM 576
            |::|.|||...|:.|.|..|..||.|..:.||.|.||.
  Rat   522 GSQCSVNGVQIVDATQLNQGAVILLGRTNMFRFNHPKE--------------------------- 559

  Fly   577 QNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGK 641
                        .|:|..:.:.....:......:..:..:.|..::.          |:|   |.
  Rat   560 ------------AAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVML----------YNP---GL 599

  Fly   642 ITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPP 706
            .....|.. :|:|...|:|:|:.:                ::....|.||||:|.| |...::..
  Rat   600 FPMKGPIC-LRLEFERQQREELEK----------------LESKRKLIEEMEEKQK-SDKAELER 646

  Fly   707 ANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEK--------LENKLIDM---REMYQEHKERVL 760
            .......||     :...:|:|     ||...|:        :||||.|:   :|.::|.:.|..
  Rat   647 MQQEVETRR-----KETEIVQR-----QIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQ 701

  Fly   761 NGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHD--------VKLDYHTPIISQQGEVAGRL 817
            .||::...:.:|.|:..:|....:      .|:..|:        ..||:   :..:|...:.:|
  Rat   702 QGLEQQKRQEEDSFFRIREELRRL------QELNSHEQAEKGQPLQDLDW---LHREQDAQSAKL 757

  Fly   818 QVEIERIAGQ----------------MPQDR---MCESVSESSGDSRDEYDDPVDPTSNQITCRV 863
            |:|..|:..|                ..||.   :|...::.:.:.|.|    ::.....:....
  Rat   758 QLEKRRLEEQEKEQVLRVAHLEEQLRKRQDTAPLLCPGEAQQAQEERRE----LEGIRGALLQAK 818

  Fly   864 TIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQ---------DFT- 918
            .|: |.|           .:||.|..|..            |....:|:..|         |..
  Rat   819 EIR-AGG-----------DHTFRGELERA------------QQYFLEFKRRQLVKLATLEKDLVQ 859

  Fly   919 --------VTINEEFLEH--CIEG----ALSIE----VWGHRSAGFSKTKGWEVEQQQAKARSLV 965
                    |...:|.|||  |..|    .|:.:    :.|.:.....||....::.::.:.:.|:
  Rat   860 QKDRLSKEVQEEKEALEHVKCEAGEEPSLLATDNCNILCGPQDLDKIKTAESRLQSKEHQLQDLL 924

  Fly   966 DRWAELSRKIELWVEIHELNDNG--------EYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022
            ..  .|...:|....:.|:.|.|        .:...|:..:.|.:|.  ||....|.:::...|
  Rat   925 QN--HLPALLEEKQRVLEILDCGVLGLDNILYHVEKEMEEKEEQITQ--YQANASQLQQLQATV- 984

  Fly  1023 PVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLR------EKWSEALGRRRQYL 1081
                        |...|||.....||.:.:..|:|.:::....|.      |:...|| :||..|
  Rat   985 ------------QFTANVARQEEKVRRKEKEILESQEKQQREALEQAVAKLEQRHSAL-KRRSTL 1036

  Fly  1082 DQQIQMLIKKEEKNEQERERELSLVH--QWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPH 1144
            |.:|           ||:.::|..:|  :|                   ||..||
  Rat  1037 DLEI-----------QEQRQKLGSLHSSEW-------------------PGLQAS---------- 1061

  Fly  1145 VPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDS 1209
                 |..||:.|       ::..|.|      ||.        :..|.:.:|.|.......|.:
  Rat  1062 -----LEANGERL-------QMDPARI------EHE--------IHELKQKICEVDGVQRPHHGT 1100

  Fly  1210 ----QALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGEN 1270
                .||:.:..:.|.           ||.||:   :..|:|..|:  :.:..||...
  Rat  1101 LEGKAALSSLPPSAEN-----------SHLAPL---MDARISAYIE--EEVQRRLHDL------- 1142

  Fly  1271 AIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESILTLDR 1335
                    :.|:|:...|..||:..|.|            .:|.|.
  Rat  1143 --------HRVISDASHAPAELKSNEEL------------HNGATQ------------------- 1168

  Fly  1336 LRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDA-------SMESLLNVGRSESFADLNNSA 1393
                   ::|:...|||.|.|  ..:|    ::..||       ..||.:......|.....|::
  Rat  1169 -------RKLKYEKGQPWSAR--CGIP----LLPKDAVDSPSVLGEESEVYPSSQWSHPVSQNTS 1220

  Fly  1394 LGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDS---PGKAFGIASPATSKLLGMRMTTLHEEPL 1455
            |...|:.|.....    |:.|.|:.  ..|.||.   | ::.|...|....||  .:::|:|
  Rat  1221 LSTDFSLASQERI----VLSSGHAV--LKSIDDKFCYP-ESSGHLEPNCVHLL--EISSLNE--- 1273

  Fly  1456 GGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQS-----YL 1515
              ..|.|.:.....|::.......:|:|   |..|.|..|.|:.|.....|...|.|:     .|
  Rat  1274 --RNSRDAQSSQIESENSSGLMTHEEKQ---SWGTESSWTLSQHMSQQAPVDRGSQQAMQSRELL 1333

  Fly  1516 SYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIA 1560
            ...|.:.:..:|.||.:..|:|:||        :||...|.:|.|
  Rat  1334 FVLSESVSQREHPTGSSPQSVSAST--------LSCEQQSEKDSA 1370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	194/358 (54%)
		KISc	6..359	CDD:214526	194/358 (54%)
		Kinesin_assoc	356..468	CDD:292801	32/119 (27%)
		FHA	446..546	CDD:238017	31/99 (31%)
		KIF1B	741..786	CDD:289208	13/47 (28%)
		DUF3694	<1196..1252	CDD:289256	13/59 (22%)
		CAP_GLY	1786..1850	CDD:279625
Kif16b	XP_038960967.1	KISc_KIF1A_KIF1B	15..368	CDD:276816	194/358 (54%)
		Kinesin_assoc	367..479	CDD:406567	33/118 (28%)
		FHA	481..546	CDD:395400	22/64 (34%)
		DUF5401	<609..>889	CDD:375164	66/343 (19%)
		sbcc	<611..>1179	CDD:129705	144/784 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920