DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif13b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_998791.1	Gene:	Kif13b / 305967	RGDID:	1303307	Length:	1767	Species:	Rattus norvegicus

Alignment Length:	1967	Identity:	869/1967 - (44%)
Similarity:	1169/1967 - (59%)	Gaps:	290/1967 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNP--PPLEKIE-RKQPKTFAFDHCFYS 62
            |...|:||||||||.|||||:|.|||:|::|..:.|| ||  ..|.|.: |.|||.||:||||:|
  Rat     1 MGDSKVKVAVRVRPMNRREIDLHTKCVVDVEANKVIL-NPINTNLSKGDARGQPKIFAYDHCFWS 64

  Fly    63 LNPE-DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQ 126
            ::.. .|.:|.|:.||.|:|..||.|||.|||||||||||||||||||||||.:..|:|||||..
  Rat    65 MDESVREKYAGQDDVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSG 129

  Fly   127 LFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSY 191
            ||.....:...|..:||||||||||||||.||||||.::|:||||||:|:||||||||:||||||
  Rat   130 LFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSY 194

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            :||::||:||||||||||||||.|||||||||.:.||..|.|..:|.|||||.::||||||||||
  Rat   195 KDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSER 259

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            |.||||.||||||||||||||||||||||.||||..||  ..:||||||||||||||||:|||||
  Rat   260 ATKTGAAGDRLKEGSNINKSLTTLGLVISALADQGAGK--NKNKFVPYRDSVLTWLLKDSLGGNS 322

  Fly   322 RTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATG 386
            :|.||||:||:||||:|||||||||||||.|:|||||||||||||||:||.|||.||..|..|..
  Rat   323 KTAMVATVSPAADNYDETLSTLRYADRAKHIINHAVVNEDPNARIIRDLREEVEKLREQLTKAEA 387

  Fly   387 SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVN 451
            ....:::|:|.|||.|:::::.||||||.|||.|..|||:.||.:|||:|.|||||..:|.:|||
  Rat   388 MKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQTSGIKVGDDKCFLVN 452

  Fly   452 LNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-LYMEPVQGARC 515
            |||||:||||||||||:.||||    |....||||.|:||.|||.:|.|...| :.:.|.:..|.
  Rat   453 LNADPALNELLVYYLKEHTLIG----SANSQDIQLCGMGILPEHGIIDIMPEGQVMLTPQKNTRT 513

  Fly   516 FVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPK----------------------------SNNT 552
            |||||:......|.:||||||||:||||:|.||                            .:::
  Rat   514 FVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEEREASLKNDSSSEQLDADGDSS 578

  Fly   553 SMCASEPQTPAQLIDYNF--ARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQ 614
            |..:||       |::||  |:.|:....| ||||:|:.::.||:||||:|:.|||:||..||.:
  Rat   579 SEVSSE-------INFNFEYAQMEVTMKALGSNDPMQSILSSLEQQHEEEKRSALERQRLMYEHE 636

  Fly   615 FQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRAN 679
            .:|||..|||..       .:...:.:::.::|::|.|:.:||:||:.....||.:|:..|::||
  Rat   637 LEQLRRRLSPER-------QNCRGVDRLSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKAN 694

  Fly   680 SLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENK 744
            .||:||:::|||::|:|::.||||||.::|..||:||:.:|||||.|:|...|.|||::|||||:
  Rat   695 LLVREASYIAEELDKRTEYKVTLQIPASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLENR 759

  Fly   745 LIDMREMYQEHKERVLNGLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYH 803
            |:|||::|||.||     .:||:.      |..||||:.||||:||||||:|||.||:||||.|.
  Rat   760 LLDMRDLYQEWKE-----CEEDSPVSRSYFKRADPFYDEQENHSLIGVANVFLETLFYDVKLQYA 819

  Fly   804 TPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSE--SSGDSRDEYDDPVDPTSNQITCRVTIK 866
            .|||:|:|||||||.||:.|::|         ::.|  :.||...|.....:...|::.|.|.|.
  Rat   820 VPIINQKGEVAGRLHVEVMRLSG---------AIGERIAGGDDPTEVSSEKEVQENRLVCMVKIL 875

  Fly   867 CASGLPLSLSNFVFCQYTFWGHQE--MVVPVINAES--TAHDQNMVFKFEHTQDFTVTINEEFLE 927
            .|:|||..|.:||||:|.||..||  .|.|.::..|  |:.:...:..|:|..:|:|.|.|:|:|
  Rat   876 QATGLPQHLCHFVFCKYDFWDQQEPVTVAPEVDTSSSPTSKEPQCMVVFDHCSEFSVNITEDFIE 940

  Fly   928 HCIEGALSIEVWGHRSAGFSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYS 991
            :..||||:|||:||:.....|... |::...|||.|||.|||:|::||:|.||:|.|.|:||||.
  Rat   941 YLSEGALAIEVYGHKMNDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGEYC 1005

  Fly   992 PVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRP-- 1054
            ||||....:|.||||:||||||.|||.|.||.||.|||||::.:.|::|.||.|.||. |:.|
  Rat  1006 PVEVIAAKDVPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRP-LRSPKT 1069

  Fly  1055 ----------LDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQW 1109
                      :||||:.||..||.||..||.:|::|||||:|.|:.|.:|.|.:.:||..|:...
  Rat  1070 HENIHEEEEDMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKHDKTEDDADREAQLLEMR 1134

  Fly  1110 VSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSI 1174
            ::||||||||:||:.|||||||||.|.|..|||.|:||:||:||.||.|:|:..|: ..||.::.
  Rat  1135 LTLTEERNAVMVPSAGSGIPGAPAEWTPVPGMEAHIPVVFLDLNADDFSSQDNLDD-PEAGWDAT 1198

  Fly  1175 LSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMD 1239
            |:.|...:|:.|||::|.|.:|...|||||::|:...|::.|.|:|||:||||..|:|||||.|.
  Rat  1199 LTGEEEEEFFELQIVKHHDGEVKAEASWDSAVHNCPQLSKGTPADERVFLILRVAVQLSHPADMQ 1263

  Fly  1240 LVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKA-SEELEDRESLAQLAA 1303
            ||||||:.:::...|.....|.|....|  ::|...|||:|:|||||:. ::.:|:||:||::||
  Rat  1264 LVLRKRICVHVHGRQGFAQSLLKKMTHR--SSIPGCGVTFEIVSNIPEVDAQGVEEREALARMAA 1326

  Fly  1304 SGDDCSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIM 1368
            :.::.:::|.|..||||.|.|.|||::||||||||.|||||..|..|:  ..|:::|.|:.:
  Rat  1327 NVENAASADSEACIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGK--LNRRSISSPSMN--- 1386

  Fly  1369 RFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFG 1433
            |...|.:.|                                                 ||..:..
  Rat  1387 RLSGSRQEL-------------------------------------------------SPSHSLS 1402

  Fly  1434 IASPATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEYAAEYEQERQQN--------KSMAT 1490
            ...|....|:                      :.::||:.  |...:|.||.        :||..
  Rat  1403 SNKPVPRILV----------------------QPTFSDAR--ATRTEEAQQGSPGPSGALESMVK 1443

  Fly  1491 RSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLS 1555
            .:..|. |..|..:.|||..:...::..........        |..|..||||.|.:||...||
  Rat  1444 MAAPTV-KICDKPVRVSSPPSTMVVTQPQEGQDGPP--------SPLSEASSGYFSHSVSTATLS 1499

  Fly  1556 NEDIASMRSMSI-DETPDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPL 1619
            ......:.:..: .:||       .|||             ...::.::||.       ||.
  Rat  1500 ETLTLGLDTTGLGSQTP-------GSPP-------------ALCQVTQEPEL-------AFL--- 1534

  Fly  1620 EQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTEFATDNQNGNRS 1684
                          .|.|                  |..||.||....|.:.|:
  Rat  1535 --------------SCTQ------------------SHPTDPEEPHIPPATPTQ----------- 1556

  Fly  1685 SDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAK 1749
            |.||......||...   ...:|......||...::..|....:...::|..:.|.::...|.|:
  Rat  1557 STELEVPRPPLLSDP---TPAVPTSPFRIRKVRPSELTSFTGMLGGASSGAQEDPVVSEDPSHAR 1618

  Fly  1750 MEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWI 1814
            .:.|          ...||..:|:|...| |||:..||.|::.. |.:|::|::|.|:||.|.||
  Rat  1619 GQTL----------GRLEVTSDSEDASEV-PEWLREGEYVVVGT-NKTGIVRYIGPTDFQEGTWI 1671

  Fly  1815 GVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLML-----DKRGKAMRAYKAAEKSNSISKE 1874
            |||||.|.||||||:.|.|||:|.|.:|:.||..::..     .:|...::...|.|...|.:..
  Rat  1672 GVELDLPAGKNDGSIGGKQYFRCNPGYGLLVRPGRVRRAAGTGRRRSSGLQPQGAPEARRSATIS 1736

  Fly  1875 MSTSMTGSMTRSKSRGD 1891
            .|.:...|:|.:.::||
  Rat  1737 GSATNLASLTAALAKGD 1753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	253/358 (71%)
		KISc	6..359	CDD:214526	252/356 (71%)
		Kinesin_assoc	356..468	CDD:292801	70/111 (63%)
		FHA	446..546	CDD:238017	57/100 (57%)
		KIF1B	741..786	CDD:289208	25/50 (50%)
		DUF3694	<1196..1252	CDD:289256	30/55 (55%)
		CAP_GLY	1786..1850	CDD:279625	34/63 (54%)
Kif13b	NP_998791.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	253/358 (71%)
		KISc	6..360	CDD:214526	252/356 (71%)
		Kinesin_assoc	357..469	CDD:292801	70/111 (63%)
		FHA	447..544	CDD:238017	57/100 (57%)
		KIF1B	756..802	CDD:289208	25/50 (50%)
		C2	<888..>952	CDD:301316	26/63 (41%)
		DUF3585	<1073..1143	CDD:304905	31/69 (45%)
		DUF3694	<1211..1278	CDD:289256	34/66 (52%)
		CAP_GLY	1644..1707	CDD:279625	34/63 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	472	1.000	Domainoid score	I426
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9073
Inparanoid	1	1.050	1479	1.000	Inparanoid score	I100
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm46398
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.880