DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and Kif19a

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001096085.1	Gene:	Kif19a / 286942	MGIID:	2447024	Length:	997	Species:	Mus musculus

Alignment Length:	848	Identity:	246/848 - (29%)
Similarity:	387/848 - (45%)	Gaps:	182/848 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIV-EMEKQQTIL----QNPPPLEKIERKQPKTFAFDHCFYSLN 64
            ::.||:||||.:..|:|.....|. :|::|..:|    ::|..:.:..|.:.|::.||..|
Mouse    11 QLMVALRVRPISVAELEEGATLIAHKMDEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAF---- 71

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
               :..|:||.|:....:.:::....||||.:||||.||.||:|||:||....||..|..:.||.
Mouse    72 ---DFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGTDHEPGIYVRTLNDLFR 133

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
            ||...|. ::.|:|.:||:|||||.:.|||:|...  .|::||.:.....|.|:::::..:.::|
Mouse   134 AIEETSN-DMEYEVSMSYLEIYNEMIRDLLNPALG--YLELREDSKGVIQVAGITEVSTINAKEI 195

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQ------ILTDQATGVSGEKVSRMSLVDLAG 253
            ..|:.:||:.||...|..|..|||||||..|.:.|      ||.:...|       |:.::||||
Mouse   196 MQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRSRVKNILQEVRQG-------RLFMIDLAG 253

  Fly   254 SERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ||||.:|...|.|:|||::||:||..||..|:.|:|:      |::|::.||||.||.||||:||
Mouse   254 SERASQTQNRGQRMKEGAHINRSLLALGNCINALSDK------GSNKYINYRDSKLTRLLKDSLG 312

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVET 376
            |||||||:|.|||::..:||:.:||.||.|||.|   |...::|...:    ..||.:||.|::.
Mouse   313 GNSRTVMIAHISPASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQR 377

  Fly   377 LRSMLKHATGS-------PVGDV------------QDKLAESENLMKQISQTWEEKLVKTERIQN 422
            |:..:....|.       ..||:            |:..||...|.:|:...:.|::....|:..
Mouse   378 LKCKIDQQAGRGQARGKLDRGDIRHIQAEVQLHSGQEGPAEMGQLREQLISAFHEQMDVRRRLLE 442

  Fly   423 ERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQL- 486
            ...||:|          ::::.:::.|.....:...:...:.:.::|     |..|..:.|.:.
Mouse   443 LENQAME----------VQIDTSRHLLTIAGWEHEKSRRALKWREER-----RKESYTKEDSEKD 492

  Fly   487 SGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAV--------EKTPLQNGDRILWGNHH--- 540
            |..|.:|::           :||.:.|....|.:|.|        ||..|:...|.|.....
Mouse   493 SDTGDEPDN-----------LEPPEVASARENIAALVGEQKKLRKEKLALEQRCRELRARGRRLE 546

  Fly   541 ------------------FFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQT 587
                              ..||:..:..||.|     |:.|.|      ||..:::.      :.
Mouse   547 ETLPRRIGSEEQREVLSLLCRVHELEVENTEM-----QSHALL------RDSALRHR------RE 594

  Fly   588 AIARLERQHEEDKQVALEKQRQ-------EYERQFQQLRNI---------LSPST---PYAPYAP 633
            |:.||| ||.......::.|||       |..|..::|..:         |..:|   ..|..|.
Mouse   595 AVRRLE-QHRSLCDEIIQGQRQIIDDYNLEVPRHLEELYEVYLRELEEGSLERATIMDRVASRAL 658

  Fly   634 YDPLRMGKITPN----TPTSQMR-VEKWAQERDEMFRRSLGQLKTDIMRANSLVQEAN--FLAEE 691
            .|. .:.||||.    ||.|.:. |:..:.|.......:|..|.||        .|:.  |.|..
Mouse   659 QDS-SLPKITPAGATLTPDSDLESVKTLSSEAQRPQNNTLPPLGTD--------SESYHVFKASP 714

  Fly   692 MEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQI-WTMEKLENKLIDMREMYQEH 755
            ...:.|.|.....||..:      |:.|::.|  ..:.:.|||| .:.|..||    :.|:...|
Mouse   715 RAWQVKSSSVPTPPPIQV------GSLVTQEA--PPQDSLGSQINSSPESSEN----LSEILLSH 767

  Fly   756 KER 758
            |||
Mouse   768 KER 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	145/367 (40%)
		KISc	6..359	CDD:214526	145/366 (40%)
		Kinesin_assoc	356..468	CDD:292801	21/134 (16%)
		FHA	446..546	CDD:238017	21/129 (16%)
		KIF1B	741..786	CDD:289208	7/18 (39%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Kif19a	NP_001096085.1	KISc_KIP3_like	11..346	CDD:276821	143/357 (40%)
		KISc	14..353	CDD:214526	145/361 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..509		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..704		13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..759		12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	784..997
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910