DRSC/TRiP Functional Genomics Resources

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Protein Alignment Khc-73 and KIF4B

DIOPT Version :10

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:NP_001092763.1 Gene:KIF4B / 285643 HGNCID:6322 Length:1234 Species:Homo sapiens


Alignment Length:1272 Identity:320/1272 - (25%)
Similarity:524/1272 - (41%) Gaps:320/1272 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENF 70
            ::||:|.||...:||.         |..|..|...|...::.....|:|.:|..|   :|..|  
Human    10 VRVALRCRPLVPKEIS---------EGCQMCLSFVPGETQVVVGTDKSFTYDFVF---DPCTE-- 60

  Fly    71 ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGT----QESK---GIIPRLCDQLF 128
              ||.||:.....::...|:||||.:.|||||||||:|:|.|.    ||::   |||||:...||
Human    61 --QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGIIPRVIQLLF 123

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..|..||  :..:.::|||:|||||::.|||.|...|..:.:||....|..:.||::..|....|
Human   124 KEIDKKS--DFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALD 186

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258
            ..:.:.:||.|||||:|.||::||||||:|::.:.|   .:.:..:....|::.|||||||||..
Human   187 TVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISIEQ---RKKSDKNCSFRSKLHLVDLAGSERQK 248

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            ||.|.|||||||.|||:.|..||.|||.|.|...|      .|||||||.||.||:|:|||||.|
Human   249 KTKAEGDRLKEGININRGLLCLGNVISALGDDKKG------SFVPYRDSKLTRLLQDSLGGNSHT 307

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATG-- 386
            :|:|.:||:..|.|||||||||||||::|.|..:||.||:...:..|:.:|:.|:.:|..|.|  
Human   308 LMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQAHGGT 372

  Fly   387 -------SPVGDVQDKLAESENLM-----------KQISQTWE--EKLVKTERIQNERQQALEKM 431
                   .|..::|..:.::::|:           |...||.:  |:::.||::..:....||::
Human   373 LPGSINAEPSENLQSLMEKNQSLVEENEKLSRCLSKAAGQTAQMLERIILTEQVNEKLNAKLEEL 437

  Fly   432 GISVQASGIKVEKNKYYLVNLNADPSLNE---------LLVYYLKDRTLIGGRTISGQQPDIQLS 487
            .   |....|::..|  ||....|..|.|         .|:..|.|.|:.               
Human   438 R---QHVACKLDLQK--LVETLEDQELKENVEIICNLQQLITQLSDETVA--------------- 482

  Fly   488 GLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT 552
                    |.....|:.            |...|.||.:|..:              .|..:..|
Human   483 --------CTAAAIDTA------------VEEEAQVETSPETS--------------RSSDAFTT 513

  Fly   553 SMCASEPQTPAQLIDYNFA---RDEIMQNELSND----PIQ-----------TAIARLERQHEE- 598
            .....:.|...::::.|.|   ::.:::....||    |||           ..:..|:::.|| 
Human   514 QHALHQAQMSKEVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEEL 578

  Fly   599 ----------DKQVALEKQR----QEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649
                      ..|..|.:.|    ||.|.|...|:..|:..:..        |::.:.|..| .|
Human   579 VRELQTAKKNVNQAKLSEHRHKLLQELEGQIADLKKKLNEQSKL--------LKLKESTERT-VS 634

  Fly   650 QMRVEKW--AQERDEMFRRSLGQLKTDIMRANSLVQEAN---FLAEEMEKKTKFSVTLQIPPANL 709
            ::..|.|  ..:|.::.|    |:|.|..:.....|:.:   ...:|.::|.::.:      ..|
Human   635 KLNQEIWMMKNQRVQLMR----QMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYEL------LKL 689

  Fly   710 SPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPF 774
            ..|     |..:.::|.::|...:.  ..::|::.|...||:..:.||...:|.:...|:.:   
Human   690 ERN-----FQKQSSVLRRKTEEAAA--ANKRLKDALQKQREVTDKRKETQSHGKEGIAARVR--- 744

  Fly   775 YESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEI----ERIAGQMPQDRMCE 835
                   |.:|..   :||:....:...|...:.:..::..:..|::    |......|:.|.|.
Human   745 -------NWLGNE---IEVMVSTEEAKRHLNDLLEDRKILAQDVVQLKEKKESRENPPPKLRKCT 799

  Fly   836 -SVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAE 899
             |:||..|... |.:|.:......:...:.::.|....|...                  :::||
Human   800 FSLSEVHGQVL-ESEDCITKQIESLETEMELRSAQIADLQQK------------------LLDAE 845

  Fly   900 STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEG---------ALSIEVWGHRSAGFSKTKGWEVE 955
            |                      |:..:.|.|.         ||...:....|:....|| .|..
Human   846 S----------------------EDRPKQCWENIATILEAKCALKYLIGELVSSKIHVTK-LENS 887

  Fly   956 QQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVR 1020
            .:|:||..     |::.:.:        ..:...:|.:|...:.|::     ::.|..|.:|...
Human   888 LRQSKASC-----ADMQKML--------FEEQNHFSEIETELQAELV-----RMEQQHQEKVLYL 934

  Fly  1021 VKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLD---SYQEEDLTVLREKWSEALGRRRQYLD 1082
            |..:|.|                     ...::.|:   |.:|:.|....:...|.|.:.|:..:
Human   935 VSQLQES---------------------QMAEKQLEKSASEKEQQLVSTLQCQDEELEKMREVCE 978

  Fly  1083 QQIQMLIKKEEKNEQERERELSLVHQWVSLTE--ERNAVLVPAPGSGIPGAPASWE--PPSGMEP 1143
            |..|:|        ||.|    ::.|.:.|.:  .|...|   |...:....:|:|  ||.....
Human   979 QNQQLL--------QENE----IIKQKLILLQVASRQKHL---PNDTLLSPDSSFEYIPPKPKPS 1028

  Fly  1144 HVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHG 1180
            .|...||..:.|       .::|.....:|:...|.|
Human  1029 RVKEKFLEQSMD-------IEDLKYCSEHSVNEHEDG 1058

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 158/359 (44%)
Kinesin_assoc 356..468 CDD:465047 31/142 (22%)
FHA_KIF13 446..547 CDD:438758 17/109 (16%)
KIF1B 741..786 CDD:463574 9/44 (20%)
DUF3694 989..1243 CDD:463599 39/199 (20%)
CAP_GLY 1785..1850 CDD:460154
KIF4BNP_001092763.1 KISc_KIF4 8..337 CDD:276823 156/353 (44%)
Smc <429..>986 CDD:440809 123/738 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 5/32 (16%)
Interaction with PRC1. /evidence=ECO:0000250|UniProtKB:O95239 663..1234 89/525 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..737 7/24 (29%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O95239 793..798 2/4 (50%)
Globular. /evidence=ECO:0000250 1000..1234 15/69 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1076 2/7 (29%)
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250|UniProtKB:O95239 1086..1144
SET 1086..>1126 CDD:394802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1234
Blue background indicates that the domain is not in the aligned region.

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