DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and klp8

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_594675.1	Gene:	klp8 / 2542849	PomBaseID:	SPAC144.14	Length:	511	Species:	Schizosaccharomyces pombe

Alignment Length:	491	Identity:	156/491 - (31%)
Similarity:	253/491 - (51%)	Gaps:	81/491 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQ-------PKTFAFDH 58
            |::..::|.|||||.:.||:....:.::.::.....:...||...::..:       |:|||||.
pombe     1 MSTANVRVIVRVRPKSLRELSKSAEDLLSVDSHNKTVTITPPKHGLKHSRHKNRVNGPRTFAFDE 65

  Fly    59 CFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRL 123
            ||....||.:|.:.||.|::..|..::.:..:|:|:|...|||.|:||:|:::|.:...||||.:
pombe    66 CFAPSAPESKNLSGQEDVYESTGPLLVKSILEGFNSCFITYGQKGTGKTYSVVGLRGQPGIIPHI 130

  Fly   124 CDQLFSAI--ANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNK-----QSLKVREHNVMGPYVD 181
            .:.:|..|  ..|.:|.....|.:|..||..|..:|||.|..|.     :::.|::.::.|.::.
pombe   131 SESIFEEIDKLKKKSPNTTITVSISLAEIIEETPYDLLQPNVNSSHTPGETVFVQKDSLTGYHLH 195

  Fly   182 GLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESS------RSHAVFSVVLTQILTDQATGVSG 240
            |||:..|.|.|:||..:       .:||.|:..|.|      :.|:|||:|:.|.:.|..|..|.
pombe   196 GLSEFEVGSAQEIDAFL-------RLAAKNIRTELSDISGVRKGHSVFSLVVQQRIIDPKTRHSL 253

  Fly   241 EKVSRMSLVDLA----GSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKF 301
            :|.||:.::|||    ||:|.....:.     |.|:.||||:.|..||:.|..:.      ||..
pombe   254 KKASRLQIIDLASFSKGSQRNESISSF-----ESSSNNKSLSVLNRVIAALTSKK------NDVL 307

  Fly   302 VPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARI 366
            :||:|||||.||:|.||||.||:|:..:||.  ::::|.|.|||::.|:||.|.:.:|
pombe   308 IPYKDSVLTTLLQDALGGNCRTIMLTCVSPC--DFDDTFSALRYSEAARRIKNISNIN------- 363

  Fly   367 IRELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWE--EKLVK-TERIQN---ERQ 425
            .:|            .::|.:. |::.|.|...|:..:|:.:..|  :||:| .|.|:|   ||.
pombe   364 CKE------------AYSTNNE-GELDDILTTLESDREQLRRHEEHSQKLLKFIEEIRNDYEERI 415

  Fly   426 QALEKMGISVQASGIKVEKNKYYLVNLNADPSLNEL 461
            .|||.     |.|.:|..      :.|..|..||.|
pombe   416 HALES-----QNSALKAH------LRLAVDAYLNPL 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	127/378 (34%)
		KISc	6..359	CDD:214526	127/376 (34%)
		Kinesin_assoc	356..468	CDD:292801	28/112 (25%)
		FHA	446..546	CDD:238017	5/16 (31%)
		KIF1B	741..786	CDD:289208
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
klp8	NP_594675.1	KISc	5..354	CDD:276812	123/368 (33%)
klp8	NP_594675.1	Kinesin	11..356	CDD:278646	122/364 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810