DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF13B

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_011542759.1	Gene:	KIF13B / 23303	HGNCID:	14405	Length:	1847	Species:	Homo sapiens

Alignment Length:	1994	Identity:	888/1994 - (44%)
Similarity:	1192/1994 - (59%)	Gaps:	264/1994 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNP--PPLEKIE-RKQPKTFAFDHCFYS 62
            |...|:|||||:||.||||.:|.|||:|:::..:.|| ||  ..|.|.: |.|||.||:||||:|
Human     1 MGDSKVKVAVRIRPMNRRETDLHTKCVVDVDANKVIL-NPVNTNLSKGDARGQPKVFAYDHCFWS 64

  Fly    63 LNPE-DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQ 126
            ::.. .|.:|.|:.||.|:|..||.|||.|||||||||||||||||||||||.:..|:|||||..
Human    65 MDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSG 129

  Fly   127 LFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSY 191
            ||.....:...|..:||||||||||||||.||||||.::|:||||||:|:||||||||:||||||
Human   130 LFERTQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLGPYVDGLSKLAVTSY 194

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            :||::||:||||||||||||||.|||||||||.:.||..|.|..:|.|||||.::||||||||||
Human   195 KDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGTSGEKVGKLSLVDLAGSER 259

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            |.||||.||||||||||||||||||||||.|||||.||  ..:||||||||||||||||:|||||
Human   260 ATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGK--NKNKFVPYRDSVLTWLLKDSLGGNS 322

  Fly   322 RTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATG 386
            :|.||||:||:||||:|||||||||||||.|||||||||||||||||:||.|||.||..|..|..
Human   323 KTAMVATVSPAADNYDETLSTLRYADRAKHIVNHAVVNEDPNARIIRDLREEVEKLREQLTKAEA 387

  Fly   387 SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVN 451
            ....:::|:|.|||.|:::::.||||||.|||.|..|||:.||.:|||:|:|||||..:|.:|||
Human   388 MKSPELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESLGISLQSSGIKVGDDKCFLVN 452

  Fly   452 LNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-LYMEPVQGARC 515
            |||||:||||||||||:.||||    |....||||.|:||.||||:|.|...| :.:.|.:..|.
Human   453 LNADPALNELLVYYLKEHTLIG----SANSQDIQLCGMGILPEHCIIDITSEGQVMLTPQKNTRT 513

  Fly   516 FVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPA--------QL------- 565
            |||||:......|.:||||||||:||||:|.||....:....|.|.|:        ||
Human   514 FVNGSSVSSPIQLHHGDRILWGNNHFFRLNLPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSS 578

  Fly   566 --------IDYNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNI 621
                    .:|.:|:.|:....| ||||:|:.:..||:||||:|:.|||:||..||.:.:|||..
Human   579 SEVSSEVNFNYEYAQMEVTMKALGSNDPMQSILNSLEQQHEEEKRSALERQRLMYEHELEQLRRR 643

  Fly   622 LSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEAN 686
            |||.       ..:...|.:.:.::|::|.|:.:||:||:.....||.:|:..|::||.||:|||
Human   644 LSPE-------KQNCRSMDRFSFHSPSAQQRLRQWAEEREATLNNSLMRLREQIVKANLLVREAN 701

  Fly   687 FLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREM 751
            ::|||::|:|::.||||||.::|..||:||:.:|||||.|:|...|.|||::|||:|:|:|||::
Human   702 YIAEELDKRTEYKVTLQIPASSLDANRKRGSLLSEPAIQVRRKGKGKQIWSLEKLDNRLLDMRDL 766

  Fly   752 YQEHKERVLNGLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQ 810
            |||.||     .:|||.      |..||||:.||||:||||||:|||.||:||||.|..|||:|:
Human   767 YQEWKE-----CEEDNPVIRSYFKRADPFYDEQENHSLIGVANVFLESLFYDVKLQYAVPIINQK 826

  Fly   811 GEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSL 875
            |||||||.||:.|::|.: .:|:      :.||...|.....:...|::.|.|.|..|:|||..|
Human   827 GEVAGRLHVEVMRLSGDV-GERI------AGGDEVAEVSFEKETQENKLVCMVKILQATGLPQHL 884

  Fly   876 SNFVFCQYTFWGHQE--MVVPVI--NAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSI 936
            |:||||:|:||..||  :|.|.:  ::.|.:.:.:.:..|:|..:|:|.|.|:|:||..||||:|
Human   885 SHFVFCKYSFWDQQEPVIVAPEVDTSSSSVSKEPHCMVVFDHCNEFSVNITEDFIEHLSEGALAI 949

  Fly   937 EVWGHRSAGFSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNE 1000
            ||:||:.....|... |::...|||.|||.|||:|::||:|.||:|.|.|:||||.||||.:..:
Human   950 EVYGHKINDPRKNPALWDLGIIQAKTRSLRDRWSEVTRKLEFWVQILEQNENGEYCPVEVISAKD 1014

  Fly  1001 VLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRP----------- 1054
            |.||||:||||||.|||.|.||.||.|||||::.:.|::|.||.|.||. |:.|
Human  1015 VPTGGIFQLRQGQSRRVQVEVKSVQESGTLPLMEECILSVGIGCVKVRP-LRAPRTHETFHEEEE 1078

  Fly  1055 -LDSYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNA 1118
             :||||:.||..||.||..||.:|::|||||:|.|:.|.:|.|.:.:||..|:...::|||||||
Human  1079 DMDSYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKRDKTEDDADREAQLLEMRLTLTEERNA 1143

  Fly  1119 VLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKF 1183
            |:||:.|||||||||.|.|..|||.|:||:||:||.||.|:|:..|:....|.::.|:.|...:|
Human  1144 VMVPSAGSGIPGAPAEWTPVPGMETHIPVIFLDLNADDFSSQDNLDDPEAGGWDATLTGEEEEEF 1208

  Fly  1184 YTLQILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSI 1248
            :.|||::..|.:|...|||||::|....|:|.|..:||::||:|.||:|||||.|.||||||:.:
Human  1209 FELQIVKQHDGEVKAEASWDSAVHGCPQLSRGTPVDERLFLIVRVTVQLSHPADMQLVLRKRICV 1273

  Fly  1249 NIKKGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDG 1313
            |:...|.....|.|  .:...::|...|||:|:|||||:.::.:|:||:||::||:.::.:::|.
Human  1274 NVHGRQGFAQSLLK--KMSHRSSIPGCGVTFEIVSNIPEDAQGVEEREALARMAANVENPASADS 1336

  Fly  1314 ETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFD------- 1371
            |.|||||.|.|.|||::||||||||.|||||..|..|: || |:::|.||.:::..::
Human  1337 EAYIEKYLRSVLAVENLLTLDRLRQEVAVKEQLTGKGK-LS-RRSISSPNVNRVSVWNQALCCAW 1399

  Fly  1372 -----------ASMESLL-------NVGRSESFADLNNSALGNKFTPA---------GHSP-AGA 1408
                       .|.:.|:       |.||.||..|::.:.:.....||         .||| .|.
Human  1400 DFSPLLFSWLSGSRQDLIPSYSLGSNKGRWESQQDVSQTTVSRGIAPAPALSVSPQNNHSPDPGL 1464

  Fly  1409 GGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLL-----------GMRMTTLHEEPLGGHRSLD 1462
            ..:          .:|..:|.|:|   .|...|||           |.|.:.|..:|:.......
Human  1465 SNL----------AASYLNPVKSF---VPQMPKLLKSLFPVRDEKRGKRPSPLAHQPVPRIMVQS 1516

  Fly  1463 EEPEDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKH 1527
            ..|:...:..|   |.:.|...:..:.|.. ..|.|..|....|.|......::..:.|.....
Human  1517 ASPDIRVTRME---EAQPEMGPDVLVQTMG-APALKICDKPAKVPSPPPVIAVTAVTPAPEAQD- 1576

  Fly  1528 LTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRVNSNSPPNRQARVNPFL 1592
                ...|..|..||||.|.:||...||:.           ..|..|   :.:||.
Human  1577 ----GPPSPLSEASSGYFSHSVSTATLSDA-----------LGPGLD---AAAPPG--------- 1614

  Fly  1593 KDMPKAKIQEQPEQQAKKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSS 1657
             .||.|. :.:||............|.|:....|...|                       |...
Human  1615 -SMPTAP-EAEPEAPISHPPPPTAVPAEEPPGPQQLVS-----------------------PGRE 1654

  Fly  1658 QTDLEESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKKSNTQPP 1722
            :.|||    .|...:.|.....   |:|:..|.|.  :|.||                 ....|.
Human  1655 RPDLE----APAPGSPFRVRRV---RASELRSFSR--MLAGD-----------------PGCSPG 1693

  Fly  1723 SNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVLPEWIVVGE 1787
            :.||:         .||....:|               :.:.|.|.||        :|||:..||
Human  1694 AEGNA---------PAPGAGGQA---------------LASDSEEADE--------VPEWLREGE 1726

  Fly  1788 SVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLM- 1851
            .|.:..:.| ||:|:||..:||.|.|:|||||.|:||||||:.|.|||:|.|.:|:.||..::.
Human  1727 FVTVGAHKT-GVVRYVGPADFQEGTWVGVELDLPSGKNDGSIGGKQYFRCNPGYGLLVRPSRVRR 1790

  Fly  1852 ----LDKRGKAMRAYKAAEKSNSISKEMSTSMTGSMTRSKSRGD 1891
                :.:|...:| ..|.|...|.:...|.:...|:|.:.::.|
Human  1791 ATGPVRRRSTGLR-LGAPEARRSATLSGSATNLASLTAALAKAD 1833

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	252/358 (70%)
		KISc	6..359	CDD:214526	251/356 (71%)
		Kinesin_assoc	356..468	CDD:292801	70/111 (63%)
		FHA	446..546	CDD:238017	58/100 (58%)
		KIF1B	741..786	CDD:289208	25/50 (50%)
		DUF3694	<1196..1252	CDD:289256	30/55 (55%)
		CAP_GLY	1786..1850	CDD:279625	34/63 (54%)
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	252/358 (70%)
		KISc	6..360	CDD:214526	251/356 (71%)
		Kinesin_assoc	357..469	CDD:292801	70/111 (63%)
		FHA	447..544	CDD:238017	58/100 (58%)
		RILP-like	<610..710	CDD:304877	42/106 (40%)
		KIF1B	756..802	CDD:289208	25/50 (50%)
		DUF3585	<1099..1143	CDD:304905	20/43 (47%)
		DUF3694	<1221..1279	CDD:289256	30/57 (53%)
		Jun	<1560..1664	CDD:281890	30/160 (19%)
		CAP_GLY	1725..1788	CDD:279625	34/63 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I377
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9073
Inparanoid	1	1.050	1534	1.000	Inparanoid score	I96
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm42243
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.840