DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and klp-13

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001360738.1	Gene:	klp-13 / 180865	WormBaseID:	WBGene00002224	Length:	678	Species:	Caenorhabditis elegans

Alignment Length:	881	Identity:	229/881 - (25%)
Similarity:	377/881 - (42%)	Gaps:	241/881 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDT-KCIVEMEKQQTILQNPPPLEKIE-------RKQPKTFAFD 57
            |...::.|.|||||.|..|..... :|:..::|::.:|.:|   ||.|       |:..:.|.||
Worm     3 MQKQQLTVVVRVRPLNSGEKSRKAFQCVFPLDKKRVLLVDP---EKFENNILRQNRQHERKFEFD 64

  Fly    58 HCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPR 122
            ..|.:.       ::||.|.:.....|:|:..:|:||.:||||.|||||::||:||::..|::..
Worm    65 ASFGAT-------SNQEDVHETTTGPIIDSVVEGFNATVFAYGATGSGKTFTMIGTKDRPGLMTL 122

  Fly   123 LCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREH-NVMGPYVDGLSQL 186
            :...|:..:.|:      |:|.:||||||||.:.|||:|......|...|. |:..|   |||.:
Worm   123 MTKTLYEKLDNQ------YQVLLSYMEIYNEIIRDLLNPSGGDLELLEDERGNIRVP---GLSSV 178

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDL 251
            ...:...|..::.|||..||..||..|..||||||:..|:   |:.:|:..      |::.::||
Worm   179 KAPNLTRIMQILQEGNLRRTQEATMANKTSSRSHALLQVM---IVKNQSLH------SKLFMIDL 234

  Fly   252 AGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDN 316
            ||||||..|...|.|||||:.||:||..||.||:.||.::.       |||.||||.||.||||:
Worm   235 AGSERASNTQNRGIRLKEGAAINRSLLALGNVINSLASKTT-------KFVNYRDSKLTRLLKDS 292

  Fly   317 LGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPN-----ARIIRELRHEVET 376
            |||.::|.|:|.::||:.|:|||.:||.||.||..|.|..:.|...:     |..:..:|.||
Worm   293 LGGTAKTCMIAHVTPSSSNFEETYNTLMYASRAMNITNKPMRNRPASADQVYAEAMNAIRKEV-- 355

  Fly   377 LRSMLKHA---TGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS 438
             .|.:|::   ||........:.:.|.|..|.||:            .:...:|.:.|.|
Worm   356 -GSQIKNSSSITGLAARSSVQERSSSRNRPKSISR------------NSSLTRAAQPMPI----- 402

  Fly   439 GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDS 503
                            |......|...||::.:    |:|.:|..::        |..:.|.:::
Worm   403 ----------------DRGRGGSLFTQLKEQYM----TLSDKQKRLR--------EKLMATNQEA 439

  Fly   504 -GLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLID 567
             .|.|             :.:.|..:.|.    |..||
Worm   440 YSLEM-------------SLISKNAIINA----WEKHH--------------------------- 460

  Fly   568 YNFARDEIMQNELSNDPIQTAIARLERQHE--EDKQVALEKQRQEYERQFQQLRNILSPSTPYAP 630
                          :|....:|.||::..|  ..:.|.|..||.:.|:
Worm   461 --------------HDKTAESIERLKKDGELQRVRLVELSDQRTKVEK----------------- 494

  Fly   631 YAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKK 695
                 .||.|:...:...|:||......|:.|:.:              .:|:.|...|:::...
Worm   495 -----ALRKGEENASGLESRMRSLASTNEQREVVK--------------LMVKMAEIEAQKISAL 540

  Fly   696 TKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSG-SQIWTMEKLENKLIDMREMYQEHKERV 759
            :..::              ||       :::.||::. :::...|.:.:||||.:
Worm   541 SDLAI--------------RG-------LIMDRTDTSIAKLQKYEMVADKLIDGK---------- 574

  Fly   760 LNGLDEDNAKPQDPFY---ESQENHNLIGVANIFLEVLFHDVKL-----DYHTPIISQQGEVAGR 816
               ||:::.|..:..|   ::|.:::|:.:.||...|.::.:.|     :.:|.||..:...|.:
Worm   575 ---LDDNDRKKLEEEYRVIKNQFHYHLLPLKNIQTTVSWNSMLLPKIINNNNTIIIEDRLMSASK 636

  Fly   817 LQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPV 852
            .:.||........:::...|.:||:.|. |..:.||
Worm   637 KKSEISLPLIANGREKYPTSSAESTTDD-DRVNSPV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	142/363 (39%)
		KISc	6..359	CDD:214526	142/361 (39%)
		Kinesin_assoc	356..468	CDD:292801	20/119 (17%)
		FHA	446..546	CDD:238017	16/100 (16%)
		KIF1B	741..786	CDD:289208	10/47 (21%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
klp-13	NP_001360738.1	Motor_domain	7..328	CDD:354959	140/355 (39%)
klp-13	NP_001360738.1	iSH2_PI3K_IA_R	413..>513	CDD:355389	30/191 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910