DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and bmk-1

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001379525.1	Gene:	bmk-1 / 179948	WormBaseID:	WBGene00000257	Length:	963	Species:	Caenorhabditis elegans

Alignment Length:	1193	Identity:	271/1193 - (22%)
Similarity:	468/1193 - (39%)	Gaps:	332/1193 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDK--------IKVAVRVRPFNRREIELDTKC--IVEMEKQQTILQNPPPLEKIERKQPKTFA 55
            |||.|        ::||||:||.|  ..|...||  :|:::|.:         :.||.|..   :
Worm     6 MASRKKHSEPTSNLRVAVRIRPMN--GTERSEKCTNVVKVDKGK---------QAIELKGK---S 56

  Fly    56 FDHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMG-------- 112
            |...|.:.:|:    .:||.::..:....:.....|:|..:|||||||:||::||.|
Worm    57 FGPFFRTYDPD----TTQEEIYSDLVSSQIKKVIAGFNCTVFAYGQTGTGKTFTMEGGRTDAKSS 117

  Fly   113 -TQESKGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVR---EH 173
             ...:.|||||..:.:|..:......|  |.:.|||:|:|||::.|||....|:...::|   :.
Worm   118 TDDPTTGIIPRAVEDIFEQLERCGCEE--YSLRVSYIELYNEELFDLLASTDNEDRERLRIFDDP 180

  Fly   174 NVMGPYVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGV 238
            |..|..|.|:.::.|.:..|:..|:..|.:.|..|||.||..|||||::|.|.:. |..:..||.
Worm   181 NKKGVIVSGVEEVPVRNRSDVFKLLQLGAEKRRTAATLMNMHSSRSHSLFMVNVV-IRENTTTGE 244

  Fly   239 SGEKVSRMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVP 303
            ...|..:::||||||||...::||.|:|.||..:||:||.|||.||..|        :.|.:.:|
Worm   245 ELVKQGKLNLVDLAGSENIGRSGAQGNRAKEAGSINQSLLTLGRVIRLL--------TTNGQHIP 301

  Fly   304 YRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR-II 367
            ||:|.||.||:|:|||::.|.::||:|||:.|:||:.|||.||.||..|.|..|.|...:.: |:
Worm   302 YRESKLTRLLQDSLGGSTITSLIATLSPSSSNFEESQSTLEYAMRAANIKNKPVCNTKLSKKTIL 366

  Fly   368 RELRHEVETLRSMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVK-TERIQNERQ---QAL 428
            :|...|:|.||..|:.|            .|...::  |||...::..| :|::|...|   .|:
Worm   367 KEYSDEIEKLRRDLRAA------------REKNGVI--ISQESHDEFQKNSEKVQELEQHLDNAV 417

  Fly   429 EKMGISVQASGIKVEKNKYYLVNLNADPSLNEL------LVYYLKDRTLIGGRTISGQQPDIQLS 487
            :::.|..:.             .::.|....:|      |...|:||.
Worm   418 DRLRIFTED-------------QMHMDEQYRQLYERKGELEDRLRDRI----------------- 452

  Fly   488 GLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNT 552
                                           ...||::..|.:.:.:|  |.|...:.  ..:.:
Worm   453 -------------------------------REMAVKEKELADTNDVL--NKHIEVIG--LMHTS 482

  Fly   553 SMCASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVA--LEKQRQEYERQF 615
            ::.|.:..|.:|     .|.|| ||.:|.  .....:..:||..:.:|.|.  ..|:..::....
Worm   483 ALKAFDQLTTSQ-----GAADE-MQTDLR--AFWRKVDEMERADDRNKIVIDHFSKKMSDFIDTT 539

  Fly   616 QQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTD---IMR 677
            .:|.|.|...         ..|...|::.|.......:|  :..||  ...:...::|.   ||:
Worm   540 SKLTNSLKAD---------GDLLSKKLSENICPHVKSME--SAHRD--IESTAMDMETHAICIMK 591

  Fly   678 ANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLE 742
            .:|          |.|||...::|     |....||.|                      :|.:.
Worm   592 KSS----------EAEKKVIDNMT-----AISMENRIR----------------------LETVM 619

  Fly   743 NKLIDMREMY----QEHKERVLNGLDE------DNAKPQDPF-----------YESQENHNLIGV 786
            ....|..:.|    ||..:.|::.|||      |..:...|.           ||::.|.:...|
Worm   620 KTCDDFYKSYSAKSQEFTQMVVDKLDEVKKQVSDFTEDMKPLVSTLHQTTCDSYEARTNESKKNV 684

  Fly   787 ANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDP 851
            .::              ....|...:....|.:::|:::.::.::...:.:::.
Worm   685 EHV--------------RAACSSMADSMKALMLQVEQLSTKVAENHEKQVIADQ----------- 724

  Fly   852 VDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK-FEHTQ 915
                :||.|...|:..|..:..||             ::.:|...:.:....|.....| .:..|
Worm   725 ----NNQETILDTLNTAETVVQSL-------------EDNIVETCDVKQEMDDTKKTLKQTDAKQ 772

  Fly   916 DFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKAR----SLVDRWAELSRKIE 976
            :..:.:.:|..|. .|..:.:.:         |:...|.|..:.:||    :|..|::..|.|.:
Worm   773 ENHIQVEKERAEE-KENEVKVAL---------KSFSDEAEATRGEAREFSNTLKSRFSATSEKCK 827

  Fly   977 L------------WVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGT 1029
            :            ..|:..|.|....|.:.||..:..:...:..:.......|..|:.|     :
Worm   828 VTGELVSDCTKKATDELSSLLDEFTKSTIVVTKESAAVVNSVVLVHVDPSVNVPQRILP-----S 887

  Fly  1030 LPIICQSIVNVAIGSVTVRSRLQRPL------------DSYQEEDLTVLREKWSEALGRRRQYLD 1082
            .|::               |.|.:|:            |.:..::|...:.:.:..: ||...|:
Worm   888 FPLV---------------SELNQPVEPEVLLGFGEGNDDFDTDELATKKRRVTSFV-RRDSLLE 936

  Fly  1083 QQIQML-----IKKEEKNEQERE 1100
            .....|     ||:.|:..:|.|
Worm   937 TTNNFLSPSSIIKRREQAIEEEE 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	136/376 (36%)
		KISc	6..359	CDD:214526	135/366 (37%)
		Kinesin_assoc	356..468	CDD:292801	24/122 (20%)
		FHA	446..546	CDD:238017	12/105 (11%)
		KIF1B	741..786	CDD:289208	13/65 (20%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
bmk-1	NP_001379525.1	Motor_domain	17..359	CDD:419868	136/370 (37%)
bmk-1	NP_001379525.1	CCDC158	<365..>839	CDD:318193	107/662 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910