DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and osm-3

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001367796.1	Gene:	osm-3 / 177141	WormBaseID:	WBGene00003884	Length:	699	Species:	Caenorhabditis elegans

Alignment Length:	805	Identity:	238/805 - (29%)
Similarity:	376/805 - (46%)	Gaps:	178/805 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQP----KTFAFDHCFYSL 63
            ::.::||||.||||:||.:|:|...|.|         .|.:.::....|    |.|.||..::.
Worm     2 AESVRVAVRCRPFNQREKDLNTTLCVGM---------TPNVGQVNLNAPDGAAKDFTFDGAYFM- 56

  Fly    64 NPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQ---ESKGIIPRLCD 125
                  .::.|.:::.:...:::|..:|||..:||||||||||:::|.|.:   ..:|:|||..|
Worm    57 ------DSTGEQIYNDIVFPLVENVIEGYNGTVFAYGQTGSGKTFSMQGIETIPAQRGVIPRAFD 115

  Fly   126 QLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTS 190
            .:|:|.|  :|..:.:.|..||:|||||:|.|||. ..|||.|:::|....|.||.|||......
Worm   116 HIFTATA--TTENVKFLVHCSYLEIYNEEVRDLLG-ADNKQKLEIKEQPDRGVYVAGLSMHVCHD 177

  Fly   191 YQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSE 255
            ......|||.|..:|.|.||.||.:|||||::|:|.:     :..|.....::.:::||||||||
Worm   178 VPACKELMTRGFNNRHVGATLMNKDSSRSHSIFTVYV-----EGMTETGSIRMGKLNLVDLAGSE 237

  Fly   256 RAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGN 320
            |..||||.||||||.:.||.||:.||.|||.|.|       |..|.:|||||.||.||:|:||||
Worm   238 RQSKTGATGDRLKEATKINLSLSALGNVISALVD-------GKSKHIPYRDSKLTRLLQDSLGGN 295

  Fly   321 SRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKH-- 383
            ::|:|:|.:|||:|||:|||||||||:|||.|.|...:||||...::||.:.|:..|:||::.
Worm   296 TKTIMIACVSPSSDNYDETLSTLRYANRAKNIKNKPTINEDPKDALLREYQEEIARLKSMVQPGA 360

  Fly   384 -ATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKY 447
             ..|:|..|......|.:.|.::..:...:...:.||.|..:.: |:|...|::|...:...|
Worm   361 VGVGAPAQDAFSIEEERKKLREEFEEAMNDLRGEYEREQTSKAE-LQKDLESLRADYERANAN-- 422

  Fly   448 YLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQG 512
             |.|||.:.:..:  :..|:|: .|||                          |::|
Worm   423 -LDNLNPEEAAKK--IQQLQDQ-FIGG--------------------------EEAG-------- 449

  Fly   513 ARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDE--I 575
                        .|.|:..           |:...|.       :|.:|.......|..:|:  :
Worm   450 ------------NTQLKQK-----------RMKQLKE-------AETKTQKLAAALNVHKDDPLL 484

  Fly   576 MQNELSNDPIQTAIARLERQHE---------EDKQVALEKQRQEY----ERQFQQLRNILSPSTP 627
            .....:.:.:....::||::.:         ||.....|..|.:|    .:|.|||:.::.
Worm   485 QVYSTTQEKLDAVTSQLEKEVKKSKGYEREIEDLHGEFELDRLDYLDTIRKQDQQLKLLMQ---- 545

  Fly   628 YAPYAPYDPLRMGKITP----NTPTSQM-RVEK---WAQERDEMFRRSLGQLKTDIMRANS-LVQ 683
                      .|.||.|    :|..|.: |::|   |.::........:...:|.:..||: .:|
Worm   546 ----------IMDKIQPIIKKDTNYSNVDRIKKEAVWNEDESRWILPEMSMSRTILPLANNGYMQ 600

  Fly   684 E----------ANF---LAEEMEK-------KTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKR 728
            |          :||   |.|.:.|       .:.|....||...|        .:.|:..:...:
Worm   601 EPARQENTLLRSNFDDKLRERLAKSDSENLANSYFKPVKQINVIN--------KYKSDQKLSTSK 657

  Fly   729 TNSGSQIWTMEKLENKLIDMREMYQ 753
            :...|:..|.:.|.|.::....:|:
Worm   658 SLFPSKTPTFDGLVNGVVYTDALYE 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	156/361 (43%)
		KISc	6..359	CDD:214526	156/359 (43%)
		Kinesin_assoc	356..468	CDD:292801	28/114 (25%)
		FHA	446..546	CDD:238017	14/99 (14%)
		KIF1B	741..786	CDD:289208	3/13 (23%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
osm-3	NP_001367796.1	Motor_domain	3..327	CDD:419868	154/354 (44%)
osm-3	NP_001367796.1	SMC_prok_B	<342..559	CDD:274008	53/301 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910