Protein Alignment Khc-73 and klp-6

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_498069.1
• Gene: klp-6 / 175683
• WormBaseID: WBGene00002218
• Length: 928
• Species: Caenorhabditis elegans
• Alignment Length: 1102
• Identity: 350/1102 - (31%)
• Similarity: 525/1102 - (47%)
• Gaps: 242/1102 - (21%)

  Fly     4 DKIKVAVRVRPFNRREIELDTKCIVEM-EKQQTILQNPPPLEKIERKQPKTFAFDHCFYS----- 62
            |.|.|||||||||.||...:.|.::|| :::.|::::|      :....|.|.:||.::|
 Worm     5 DSIIVAVRVRPFNDREKTRNCKLVIEMPDEETTVIRDP------KTNDEKRFTYDHSYWSHDGFS 63

  Fly    63 ------LNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
                  |.|.|.::|.|..||:.:|||:|.||:.|||..:||||||||||||:::|.:.:|||:|
 Worm    64 EKKNGYLEPTDPHYADQRRVFEDLGRGVLANAWAGYNCSLFAYGQTGSGKSYSIVGFKNNKGIVP 128

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLL-DPKPNKQSLKVREHNVMGPYVDGLSQ 185
            .:|::||..||:.....:.::|.||.||||.|||.||| ...|.|..||||||...|.||:.|:.
 Worm   129 IVCEELFKQIADNKKKNMQFEVFVSMMEIYCEKVRDLLSSTPPPKGGLKVREHPKNGFYVENLTT 193

  Fly   186 LAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVD 250
            :.|.|:::|:..:.||.||||:|||.|||.|||:|.:..:...|..:.||.|.|.:| |.::|||
 Worm   194 VPVNSFKEIEAKIEEGTKSRTIAATQMNATSSRAHTIVKITFNQKSSKQAGGTSMKK-SEINLVD 257

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            ||||||....|..|||||||..||:||||||.||..|.| |...|||....:||||||||.|||:
 Worm   258 LAGSERQSAAGTEGDRLKEGIVINQSLTTLGRVIKALHD-SQKAKSGKKTQIPYRDSVLTCLLKN 321

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM 380
            .|||||:|:|:|.|||:..|:||||||||:|||||.|..:|||||:...|.:||||.|...|:|.
 Worm   322 ALGGNSKTIMIAAISPADINFEETLSTLRFADRAKSIKTNAVVNENQTERALRELREENLRLQSQ 386

  Fly   381 LKHATGSPVGDVQD--------KLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQA 437
            ::   |...||..:        :|||::..|:::.::|::|:  .|........|.||:.:..:
 Worm   387 IQ---GGTAGDASNEEIEKLRRQLAENQKEMEEMEKSWQQKI--AEEAAKHASGASEKVEMEAK- 445

  Fly   438 SGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPD-----IQLSGLGIQPEHCV 497
                 :|...:|.|||.||:|..::|:::.     .|.::.|.:|.     ||:|||.|.|:|
 Worm   446 -----KKKMCHLWNLNEDPALTNVIVHFIP-----VGESVVGNKPTSSGNFIQMSGLSILPQH-- 498

  Fly   498 ITIEDSG---LYMEPV-QGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP--KSNNTSMCA 556
            :|:::.|   :::.|. :....|:||.....:|.||..||:.:|.:|.:..|:|  |...|.
 Worm   499 VTLKNDGNNQIHLSPCSEDLDIFINGKPVHGETQLQQNDRVFFGGNHLYVFNNPTKKGIRTD--- 560

  Fly   557 SEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNI 621
                     |.|..|:.||.||..:
 Worm   561 ---------ITYENAQAEIAQNHAA---------------------------------------- 576

  Fly   622 LSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQ-------LKTDIMRAN 679
                                                    .:..|.||.       |:.::|...
 Worm   577 ----------------------------------------ALGNRGLGGGSKRDLILEEELMSTL 601

  Fly   680 SLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQ---IWTMEKL 741
            .|||.||.:|.|:.:..||.:.|..|       ..||.......|.||..|....   :|...:.
 Worm   602 PLVQRANAMATELGRNVKFEIVLVSP-------EMRGLTSGLTEIWVKVHNISEDTYFLWEKSRF 659

  Fly   742 ENKLIDMREMYQEHKERVLNGLDEDN-AKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTP 805
            .|:...|:|||:..::    |.::.| .|.:|||||..::...|..:.:||:.|.:.:.::...|
 Worm   660 MNRYYGMQEMYEAKQD----GSEDWNMPKERDPFYEPPDSPVFIASSVVFLQSLAYLIDVEEQFP 720

  Fly   806 IISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEY-DDPVDPTSNQITCRVTIKCAS 869
            |:...|:..|.|.|      |..|    |   |.:..:.|.|| :||.......|..:|.:..|.
 Worm   721 IVDLSGQEIGLLTV------GLSP----C---STTGKELRGEYVEDPDQLIGKNIAFKVKVISAV 772

  Fly   870 GLPLSL--SNFVFCQYTFWGHQEMVVPVI---NAESTAHDQNMVFKFEHTQDFTVTINEEFLEHC 929
            |||..:  ||   |:|.|:|.::|.....   |..:..|::...||         .:.:|..::.
 Worm   773 GLPRRILKSN---CKYRFFGSKKMTTTATVSGNTPAYGHEETFQFK---------PVTKEVADYL 825

  Fly   930 IEGALSIEVWG-HRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPV 993
            ....|.|..|| .|..|.|                        |||       :.::..|.....
 Worm   826 ANSNLYITFWGTQRPRGAS------------------------SRK-------NSISTIGSNEAR 859

  Fly   994 EVTNRNEVLTGGIYQLRQGQQRRVNVR-----VKPVQNSGTLPIICQSIVNVAIGSVTVRSR 1050
            |..|:.:.:...::|.:..:.|.::|:     :|.|.::.......||:...  ||.|::||
 Worm   860 EGPNKAKRVERLVHQAKTSENRNISVKALETVLKGVDDNENRKTRKQSMKKA--GSTTIKSR 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	184/367 (50%)
		Kinesin_assoc	356..468	CDD:465047	35/119 (29%)
		FHA_KIF13	446..547	CDD:438758	33/109 (30%)
		KIF1B	741..786	CDD:463574	14/45 (31%)
		DUF3694	989..1243	CDD:463599	14/67 (21%)
		CAP_GLY	1785..1850	CDD:460154
klp-6	NP_498069.1	KISc_KIF1A_KIF1B	5..365	CDD:276816	184/367 (50%)
		tolA	<366..>446	CDD:236545	22/90 (24%)
		FHA_KIF28P	450..552	CDD:438761	33/108 (31%)
		KIF1B	659..699	CDD:463574	13/43 (30%)