DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif16b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_036014693.1	Gene:	Kif16b / 16558	MGIID:	1098240	Length:	1908	Species:	Mus musculus

Alignment Length:	1709	Identity:	456/1709 - (26%)
Similarity:	713/1709 - (41%)	Gaps:	503/1709 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 EIELDTKCIVEMEKQQTILQNPPPLEKIE-------RKQPKTFAFDHCFYSLNPEDENFASQETV 76
            |.:|:.|.|::|||.:|.:.|   |:..|       |::.|||.:|..|||.:.:..::.|||.|
Mouse    51 EKDLEAKFIIQMEKSKTTITN---LKIPEGGTGDSGRERTKTFTYDFSFYSADTKSPDYVSQEMV 112

  Fly    77 FDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKST--PEL 139
            |..:|..::.:||:|||||:||||||||||||||||.....|:|||:|:.|||.| |::|  .|.
Mouse   113 FKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEALFSRI-NETTRWDEA 176

  Fly   140 MYKVEVSYMEIYNEKVHDLLDPKPNKQ-SLKVREHNVMGPYVDGLSQLAVTSYQDIDNLMTEGNK 203
            .::.||||:|||||:|.|||..|.:|. :|:||||...||||:.||:..|.:|.|::.||..||.
Mouse   177 SFRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYSDVEELMDAGNI 241

  Fly   204 SRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGAVGDRLK 268
            :||.|||.||..||||||:|::..||...|  ..:..|.||::.||||||||||..|||.|.|||
Mouse   242 NRTTAATGMNDVSSRSHAIFTIKFTQAKFD--AEMPCETVSKIHLVDLAGSERADATGATGVRLK 304

  Fly   269 EGSNINKSLTTLGLVISKLADQS----NGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVATI 329
            ||.||||||.|||.|||.|||.|    |........|||||||||||||||:|||||:|:|:|||
Mouse   305 EGGNINKSLVTLGNVISALADLSQDAANPLVKKKQVFVPYRDSVLTWLLKDSLGGNSKTIMIATI 369

  Fly   330 SPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVG---- 390
            ||:..||.|||||||||:|||.|:|...:|||.|.::|||||.|:..|:::|  |.|:.:.
Mouse   370 SPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLL--AQGNQIALLDS 432

  Fly   391 ----DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVN 451
                .:::||.::|..::::::.|..|..:|:.|..|:..||.|.||     |:.::....:|:.
Mouse   433 PTALSMEEKLHQNEARVQELTKEWTNKWNETQNILKEQTLALRKEGI-----GVVLDSELPHLIG 492

  Fly   452 LNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCF 516
            ::.|.....:::|:||:.....||..:..:.||.|.||.::.||||.......:.:.|::|::|.
Mouse   493 IDDDLLSTGIILYHLKEGQTYVGREDASTEQDIVLHGLDLESEHCVFENAGGTVTLIPLRGSQCS 557

  Fly   517 VNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFARDEIMQNELS 581
            |||...|:.|.|..|..||.|..:.||.|.||.
Mouse   558 VNGVQIVDATQLNQGAVILLGRTNMFRFNHPKE-------------------------------- 590

  Fly   582 NDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNT 646
                   .|:|..:.:.....:......:..:..:.|..::.          |:|   |......
Mouse   591 -------AAKLREKRKSGLLSSFSLSMTDLSKSCENLSAVML----------YNP---GLFPIKG 635

  Fly   647 PTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSP 711
            |.. :|:|...|:|:|:.:                ::....|.||||:|.| |...::.......
Mouse   636 PIC-LRLEFERQQREELEK----------------LESKRKLIEEMEEKQK-SDKAELERMQQEV 682

  Fly   712 NRRRGAFVSEPAILVKRTNSGSQIWTMEK--------LENKLIDM---REMYQEHKERVLNGLDE 765
            ..||     :...:|:|     ||...|:        :||||.|:   :|.::|.:.|...||::
Mouse   683 ETRR-----KETEIVQR-----QIRKQEESLKRRSFHIENKLKDLLAEKERFEEERLREQQGLEQ 737

  Fly   766 DNAKPQDPFYESQE---------NHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVE- 820
            ...:.::..:..:|         :|.......||.|       ||   .:..:|...:.:|::|
Mouse   738 QRRQEEESLFRIREELRKLQELNSHEQAEKVQIFQE-------LD---RLHQEQNAQSAKLRLEK 792

  Fly   821 ----------IERIAGQMPQDR--------MCESVSESSGDSRDEYDDPVDP--------TSNQI 859
                      ::|:|....|.|        :|...::.:.:.:.|.:...:.        .....
Mouse   793 RRLEEEEKEQVQRVAHLEEQLRKRQDTAPLLCPGEAQRAQEEKRELESIREALLQAKEMRAGGDH 857

  Fly   860 TCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEE 924
            |||..::.|.            ||.....:..:|.:.:.|.....|..:...|        :.||
Mouse   858 TCRDELERAQ------------QYFLEFKRRQLVKLASLEKDLVQQKDLLSKE--------VQEE 902

  Fly   925 --FLEH--CIEGA----LSIEVWGHRSAG---FSKTKGWEVEQQQAKARSLVDRWAELSRKIELW 978
              .|||  |..|.    |:.:. |:...|   ..|.|..|...|              ||:
Mouse   903 KVALEHVKCDAGGDPSFLATDD-GNILGGPPDLDKIKTAETRLQ--------------SRE---- 948

  Fly   979 VEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPI---ICQSIVNV 1040
               |:|.|              :|...:..|.:.:|     ||....:||.|.:   :||  |..
Mouse   949 ---HQLQD--------------LLQNHLPALLEEKQ-----RVLDALDSGVLGLDTTLCQ--VEK 989

  Fly  1041 AIGSVTVR--------SRLQRPLDSY--------QEEDLTVLREKWSEAL----GRRRQYLDQQI 1085
            .:|....:        |:||:...::        |||.   :|.|..|.|    .::|:.|:|.:
Mouse   990 EVGEKEEQIAQYQANASQLQQLRATFEFTANVARQEEK---VRRKEKEILESQEKQQREALEQAV 1051

  Fly  1086 QMLIKKEEKNE---------QERERELSLVH--QW----VSLTEERNAV-LVPA----------- 1123
            ..|.::....:         ||:.::|..:|  :|    .||..:..|: :.||
Mouse  1052 AKLEQRRSALQRCSTLDLEIQEQRQKLGSLHTSEWSGWQASLETDGEALEMDPARLEHEIHQLKQ 1116

  Fly  1124 ----------PGSGIPGAPA--SWEPPSGMEPHV-PVLFLNLN------------------GD-- 1155
                      |..||....|  |..||||...|: |::...::                  ||
Mouse  1117 KICEVDGVQRPHHGILEGQAVLSSLPPSGGNSHLAPLMDARISAYIEEEVQRRLHDLHRAIGDAN 1181

  Fly  1156 --DLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVASWDSSMHDSQALNR---- 1214
              ......:|:||........|..|.|..:....::..|.||..          ||.::.|
Mouse  1182 HTPADVMKSNEELHNGTTQRKLKYETGQPWSAPCVIPLLSKDAA----------DSPSVLREESE 1236

  Fly  1215 VTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRLVRGENAIWQSGVTY 1279
            :..:::|.:|:.:.|                 |::           ..|.:...|..:..||.
Mouse  1237 MCPSSQRSHLMSQNT-----------------SLS-----------TAFSMASQERMVLHSGT-- 1271

  Fly  1280 EVVSNI------PKASEELE-DRESLAQLAA----SGDDCSASDGETY--------IEKYTRGVS 1325
            |::.||      |:.|..|| :|..|.::.:    |..|...|.||:.        .||.:.|:.
Mouse  1272 ELLKNIGDKFCYPENSGHLEPNRAHLLEITSLNERSSRDAQNSQGESENGNGFMAPEEKQSWGIE 1336

  Fly  1326 AVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSESFADLN 1390
            :..::|      |:|: :::....|...:|:        |:::||..|
Mouse  1337 SSWTLL------QHVS-QQVPANRGSQQAMQ--------SRVLRFVLS----------------- 1369

  Fly  1391 NSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASPATSKLLGMRMTTLHEEPL 1455
             .:|..:..|.|.||.                          .:::|..|
Mouse  1370 -ESLSQREQPTGSSPQ--------------------------RVSAPTLS--------------- 1392

  Fly  1456 GGHRSLDEEPEDSYSDSEYAAEYEQERQQNKSM---ATRSRLTASKTM--------DSFMDVSSH 1509
                  .|:..:.|||:           :|.|:   ....|..|.|.:        |.:.|.|.|
Mouse  1393 ------CEQQNEKYSDA-----------KNTSILAPLVNIRTEAKKQLGFFYHKFSDLYKDTSGH 1440

  Fly  1510 SNQSYLSYTSSANANMKHL 1528
            ..|:.....|.|    ||:
Mouse  1441 LIQAGTKVMSQA----KHV 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	192/353 (54%)
		KISc	6..359	CDD:214526	192/353 (54%)
		Kinesin_assoc	356..468	CDD:292801	32/119 (27%)
		FHA	446..546	CDD:238017	31/99 (31%)
		KIF1B	741..786	CDD:289208	12/56 (21%)
		DUF3694	<1196..1252	CDD:289256	7/59 (12%)
		CAP_GLY	1786..1850	CDD:279625
Kif16b	XP_036014693.1	KISc_KIF1A_KIF1B	51..399	CDD:276816	192/353 (54%)
		Kinesin_assoc	398..510	CDD:406567	33/118 (28%)
		FHA	512..577	CDD:395400	22/64 (34%)
		SbcC	<644..1081	CDD:223496	102/539 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920