DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Khc-73 and Kif13a

DIOPT Version :9

Sequence 1:NP_001261000.1 Gene:Khc-73 / 36718 FlyBaseID:FBgn0019968 Length:1957 Species:Drosophila melanogaster
Sequence 2:XP_036013758.1 Gene:Kif13a / 16553 MGIID:1098264 Length:1840 Species:Mus musculus


Alignment Length:1846 Identity:917/1846 - (49%)
Similarity:1156/1846 - (62%) Gaps:233/1846 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKI-ERKQPKTFAFDHCFYSLN 64
            |:..|:||||||||.||||:||:|||:||||..||:|..||...|. |||.||.||||:||:|::
Mouse     1 MSDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQGERKPPKVFAFDYCFWSMD 65

  Fly    65 PED-ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128
            ..: ..:|.||.||.|:|.|||:.||||||||||||||||||||::|||..|..|:|||||..||
Mouse    66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGHAEQLGLIPRLCCALF 130

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..||.:......:||||||||||||||.||||||.::||||||||.|:||||||||||||||::|
Mouse   131 QRIALEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFED 195

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258
            |::||:||||||||||||||.|||||||||::::||.|.|..:|.||||||::||||||||||..
Mouse   196 IESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGEKVSKVSLVDLAGSERVS 260

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            ||||.|:||||||||||||||||||||.||||:.||  |.:||||||||||||||||||||||:|
Mouse   261 KTGAAGERLKEGSNINKSLTTLGLVISSLADQAAGK--GKNKFVPYRDSVLTWLLKDNLGGNSQT 323

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSP 388
            .|:|||||:||||||||||||||||||||||||||||||||::|||||.|||.||..|..|....
Mouse   324 SMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAKVIRELREEVEKLREQLSQAEAMK 388

  Fly   389 VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLN 453
            ..::::||.|||.|:|:::.||||||.|||.|..|||:.||.||||::.|||||..:|.||||||
Mouse   389 APELKEKLEESEKLIKELTVTWEEKLRKTEAIAQERQRQLESMGISLETSGIKVGDDKCYLVNLN 453

  Fly   454 ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITI-EDSGLYMEPVQGARCFV 517
            |||:|||||||||||.|.:|..|    ..||||.|:|||||||.|.| .|..:.:.|.:.||..|
Mouse   454 ADPALNELLVYYLKDHTRVGADT----SQDIQLFGIGIQPEHCEIDIAADGDITLTPKENARSCV 514

  Fly   518 NGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNN--------------------TSMCASEPQTP 562
            ||:.....|.|.:||||||||:||||:|.||...                    .|..:|||   
Mouse   515 NGTLVCSTTQLWHGDRILWGNNHFFRINLPKRKRRDWLKDFERETSSAEHDLDAASEASSEP--- 576

  Fly   563 AQLIDYN--FARDEIMQNELSN-----------------------------------------DP 584
                |||  ||:.|::...|::                                         ||
Mouse   577 ----DYNYEFAQMEVIMKTLNSNGGFPIVSLSAWWSSPWWSYLKILFPLLWFQTKLVHQHWERDP 637

  Fly   585 IQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649
            :|..:..||:|:.|:|:.|||:||..|||:.:|||..|||.. ..|.:..|     ::..::.|:
Mouse   638 VQNVVQVLEKQYLEEKRTALEEQRLMYERELEQLRQQLSPER-QPPSSASD-----RLAYSSQTA 696

  Fly   650 QMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRR 714
            |.:|.:||:||||:||:||.:|:..:::||:||:|||||||||.|.|.:.||||||.||||.||:
Mouse   697 QQKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRK 761

  Fly   715 RGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV-----LNGLDEDNAKPQDPF 774
            |||.||||||..:|...|:|:||:|||||||||||::|||.||.|     |.|      |..|||
Mouse   762 RGAIVSEPAIQARRKGKGTQVWTIEKLENKLIDMRDLYQEWKENVPEAKRLYG------KRGDPF 820

  Fly   775 YESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCE-SVS 838
            ||:|||||||||||:|||.||.||||.|..|||||||||||||.||:.||.|.:| :||.| ..|
Mouse   821 YEAQENHNLIGVANVFLECLFCDVKLQYAVPIISQQGEVAGRLHVEVTRITGTIP-ERMAEDDSS 884

  Fly   839 ESSGDSRDEYDDPVDPTS------NQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVV--PV 895
            |:|.:|...  :.||.:.      .::||||.||.|:|||:|||||||||||||...|..|  ||
Mouse   885 ENSSESGSL--EVVDSSGEVIHRVKKLTCRVIIKEATGLPISLSNFVFCQYTFWDQCESTVAAPV 947

  Fly   896 INAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQ 957
            ::.:   ..:.|......|.|.:|:.||:.|||||...:|||:|||||||.|| :.:..|||:..
Mouse   948 VDPDVPSPQSKDAQYTVTFSHCKDYVVTVTEEFLEFISDGALAIEVWGHRCAG-NGSPIWEVDSL 1011

  Fly   958 QAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVK 1022
            .||.|:|.|||.|::|:||:|:.|.|||:.|:|:.||:....:|.|||::|||||..|||.|.||
Mouse  1012 HAKTRTLHDRWNEVTRRIEVWISILELNELGDYAAVELHQAKDVNTGGVFQLRQGHSRRVQVTVK 1076

  Fly  1023 PVQNSGTLPIICQSIVNVAIGSVTVRS-RLQRPL-------------DSYQEEDLTVLREKWSEA 1073
            |||:|||||::.::|::|:||.||.|| :|||.|             ||||||||..:||:||:|
Mouse  1077 PVQHSGTLPLMVEAILSVSIGCVTARSTKLQRGLDSYQRDEEDGGDMDSYQEEDLNCVRERWSDA 1141

  Fly  1074 LGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPP 1138
            |.:||:|||:||:.:..|:||.|.:.|||..||.|||.||||||||||||||||||||||.|.||
Mouse  1142 LIKRREYLDEQIKKVSNKKEKTEDDMEREARLVEQWVGLTEERNAVLVPAPGSGIPGAPADWVPP 1206

  Fly  1139 SGMEPHVPVLFLNLNGDDLSAQNTNDEL---SVAGINSILSKEHGHKFYTLQILQHLDKDVCCVA 1200
            .|||.|:|||||:||.|||||   |::|   ..:|:||||.||||.:|:.|.|::|.|.:|...|
Mouse  1207 PGMETHIPVLFLDLNADDLSA---NEQLVGPHASGVNSILPKEHGSQFFYLPIIKHSDDEVSATA 1268

  Fly  1201 SWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQTLTDRLKKFRL 1265
            |||||:|||..|||||..|||:|||::|||:|||||.|:||||||::.||...|:.|..||  |.
Mouse  1269 SWDSSVHDSLHLNRVTPQNERIYLIVKTTVQLSHPAAMELVLRKRIAANIYNKQSFTQSLK--RR 1331

  Fly  1266 VRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEKYTRGVSAVESI 1330
            :...|..:..|||||:|||||||:||:||||:||.|||..::....|||||||||||||..||:|
Mouse  1332 ISLINICYSCGVTYEIVSNIPKATEEIEDRETLALLAARSENEGTLDGETYIEKYTRGVLQVENI 1396

  Fly  1331 LTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMR-------FDAS----MESLLNVG-RS 1383
            |:|:||||.|.|||..:...:  .:|:::|.||...:..       ||..    .|:.|:|. .|
Mouse  1397 LSLERLRQAVTVKEALSTKAR--HIRRSLSTPNVHNVSSSRPDLSGFDEDDKGWPENQLDVSDYS 1459

  Fly  1384 ESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-----SPGKAFGIASPATSKLL 1443
            .|:.|:  :..|   |....||         |.|..|..|.:.     ||.|||....|...|.|
Mouse  1460 SSYQDV--ACYG---TLPRDSP---------RRSKEGCPSENPHALTVSPFKAFSPQPPKFFKPL 1510

  Fly  1444 ------GMRMTTLHEEPLGGHRSL------------------DEEPEDSYSDSEYAAEYEQERQQ 1484
                  ..:...|...||....|:                  ...|.:..|..|...:.|:|..:
Mouse  1511 MPVKEEHKKRLALEARPLLSQESMPPSQAHNPGCIVTPGSNGSSMPVEHSSKPEKKIDSEEEENE 1575

  Fly  1485 NKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGL-ATLSMSSSTS---SGYG 1545
            .::::.:..||.......|.|.|.::........||:.|::.....| ..:|.|.:||   |||.
Mouse  1576 LEALSRKLMLTQPYVPVEFADFSVYNASLENREWSSSKADLTDSRALEKAVSRSPTTSSLTSGYF 1640

  Fly  1546 SQAVSCNNLSNEDIASMRSMSIDE-TPDFDRVNSNSPPNRQARVNPFL-KDMPKAKIQEQPEQQA 1608
            |.  |.:|.:..|:|...|.|.|: ......|....||      .|.| .|:..|..||..|   
Mouse  1641 SH--SASNATLSDMAVPSSDSSDQLAVSTKEVECAEPP------GPSLAPDVRPASNQELTE--- 1694

  Fly  1609 KKLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQPKSKTE 1673
                             ....|..||...:|...|:.|     ||...|...:.|..|:...:|.
Mouse  1695 -----------------VGRGSGKDETIAVPLEENSAL-----PKGTPSPQSIPEESSRMPCRTA 1737

  Fly  1674 FATDNQNGNRSSDELSHSSEDLLEGD 1699
            ..::...| .|.|  .|.:.:...|:
Mouse  1738 SCSELDVG-PSKD--GHQAREFCPGE 1760

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Khc-73NP_001261000.1 KISc_KIF1A_KIF1B 4..359 CDD:276816 261/356 (73%)
KISc 6..359 CDD:214526 260/354 (73%)
Kinesin_assoc 356..468 CDD:292801 71/111 (64%)
FHA 446..546 CDD:238017 59/100 (59%)
KIF1B 741..786 CDD:289208 30/49 (61%)
DUF3694 <1196..1252 CDD:289256 38/55 (69%)
CAP_GLY 1786..1850 CDD:279625
Kif13aXP_036013758.1 KISc_KIF1A_KIF1B 5..359 CDD:276816 261/355 (74%)
Kinesin_assoc 356..468 CDD:406567 71/111 (64%)
FHA 446..543 CDD:238017 59/100 (59%)
Smc <646..811 CDD:224117 92/170 (54%)
KIF1B 788..832 CDD:403579 30/49 (61%)
DUF3694 <1255..1319 CDD:403614 40/63 (63%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 492 1.000 Domainoid score I365
eggNOG 1 0.900 - - E2759_KOG0241
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1550 1.000 Inparanoid score I96
Isobase 1 0.950 - 0 Normalized mean entropy S2420
OMA 1 1.010 - - QHG48008
OrthoDB 1 1.010 - - D76316at2759
OrthoFinder 1 1.000 - - FOG0002517
OrthoInspector 1 1.000 - - otm44296
orthoMCL 1 0.900 - - OOG6_100247
Panther 1 1.100 - - LDO PTHR24115
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2883
SonicParanoid 1 1.000 - - X1652
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.820

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