DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF18B

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_011522687.1	Gene:	KIF18B / 146909	HGNCID:	27102	Length:	873	Species:	Homo sapiens

Alignment Length:	832	Identity:	245/832 - (29%)
Similarity:	349/832 - (41%)	Gaps:	248/832 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNP-------PPLE-----KIERKQPK--TFAF 56
            ::|.|||||...||::...:.:|::..::.::.||       |.|:     ...:|:.|  ||.|
Human    17 LQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVF 81

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|       ...|:|:.||......:||:..||||..:||||.||:||::||:|.:...||:.
Human    82 DRVF-------GEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMY 139

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            ....:|:..:..:. .|..::|.:||.|:|||::||||:|   |..|.:||....|..|.|||..
Human   140 LTTVELYRRLEARQ-QEKHFEVLISYQEVYNEQIHDLLEP---KGPLAIREDPDKGVVVQGLSFH 200

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.:.:..::|.||::||...|:.||.||||||:|.:.:.|  .|:..|:: ..:|::|||:|
Human   201 QPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQ--QDRVPGLTQAVQVAKMSLID 263

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..|.|.|:||:||:|||:||..|..|::.||| :.|:|:    .||||||.||.||||
Human   264 LAGSERASSTHAKGERLREGANINRSLLALINVLNALAD-AKGRKT----HVPYRDSKLTRLLKD 323

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHE 373
            :||||.||||:|.||||:..||:|.:||:||||||.|   :...|.:.|.:    |.|.::|:.|
Human   324 SLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAE 388

  Fly   374 VETLRSML-----------KHATGSP-VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQ 426
            |..||..|           :...||| .|...:.|..|.......||....:|....|...|
Human   389 VAALRKKLQVYEGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQE--- 450

  Fly   427 ALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGI 491
              |.:|:..|..                                    |.:.|...|.:.|
Human   451 --ESLGMEAQVE------------------------------------RAMEGNSSDQEQS---- 473

  Fly   492 QPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA 556
             ||.     ||.|                 ..|:.|.|                .|:.|.|....
Human   474 -PED-----EDEG-----------------PAEEVPTQ----------------MPEQNPTHALP 499

  Fly   557 SEPQ---TPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALE----KQRQEYERQ 614
            ..|:   .|..::.:..||      ||..|              ..||:||:    .|||   ..
Human   500 ESPRLTLQPKPVVGHFSAR------ELDGD--------------RSKQLALKVLCVAQRQ---YS 541

  Fly   615 FQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRAN 679
            ..|..|:|:|.               .||......|:..|:..:...|..|.|      .:.|..
Human   542 LLQAANLLTPD---------------MITEFETLQQLVQEEKIEPGAEALRTS------GLARGA 585

  Fly   680 SLVQEANFLAEE----------------------MEKKTKFSV-TLQIPPANLSPNRRRGAFVSE 721
            .|.||   |..|                      |.::....: ||.|||   .||       ..
Human   586 PLAQE---LCSESIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPP---GPN-------CT 637

  Fly   722 PAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDP 773
            ||       .||: |.|||               |.|..:.|:.|:  |..|
Human   638 PA-------QGSR-WPMEK---------------KRRRPSALEADS--PMAP 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	154/370 (42%)
		KISc	6..359	CDD:214526	154/370 (42%)
		Kinesin_assoc	356..468	CDD:292801	24/127 (19%)
		FHA	446..546	CDD:238017	12/99 (12%)
		KIF1B	741..786	CDD:289208	6/33 (18%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	152/360 (42%)
KIF18B	XP_011522687.1	KISc	18..367	CDD:214526	153/366 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910