Protein Alignment Khc-73 and KIF18B

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Alignment Length: 832
• Identity: 245/832 - (29%)
• Similarity: 349/832 - (41%)
• Gaps: 248/832 - (29%)

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNP-------PPLE-----KIERKQPK--TFAF 56
            ::|.|||||...||::...:.:|::..::.::.||       |.|:     ...:|:.|  ||.|
Human    17 LQVVVRVRPPTPRELDSQRRPVVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDLTFVF 81

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|       ...|:|:.||......:||:..||||..:||||.||:||::||:|.:...||:.
Human    82 DRVF-------GEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTMLGREGDPGIMY 139

  Fly   122 RLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQL 186
            ....:|:..:..:. .|..::|.:||.|:|||::||||:|   |..|.:||....|..|.|||..
Human   140 LTTVELYRRLEARQ-QEKHFEVLISYQEVYNEQIHDLLEP---KGPLAIREDPDKGVVVQGLSFH 200

  Fly   187 AVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVS-GEKVSRMSLVD 250
            ...|.:.:..::|.||::||...|:.||.||||||:|.:.:.|  .|:..|:: ..:|::|||:|
Human   201 QPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQ--QDRVPGLTQAVQVAKMSLID 263

  Fly   251 LAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKD 315
            |||||||..|.|.|:||:||:|||:||..|..|::.||| :.|:|:    .||||||.||.||||
Human   264 LAGSERASSTHAKGERLREGANINRSLLALINVLNALAD-AKGRKT----HVPYRDSKLTRLLKD 323

  Fly   316 NLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHE 373
            :||||.||||:|.||||:..||:|.:||:||||||.|   :...|.:.|.:    |.|.::|:.|
Human   324 SLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLSLKSNVTSLDCHISQYATICQQLQAE 388

  Fly   374 VETLRSML-----------KHATGSP-VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQ 426
            |..||..|           :...||| .|...:.|..|.......||....:|....|...|
Human   389 VAALRKKLQVYEGGGQPPPQDLPGSPKSGPPPEHLPSSPLPPHPPSQPCTPELPAGPRALQE--- 450

  Fly   427 ALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGI 491
              |.:|:..|..                                    |.:.|...|.:.|
Human   451 --ESLGMEAQVE------------------------------------RAMEGNSSDQEQS---- 473

  Fly   492 QPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA 556
             ||.     ||.|                 ..|:.|.|                .|:.|.|....
Human   474 -PED-----EDEG-----------------PAEEVPTQ----------------MPEQNPTHALP 499

  Fly   557 SEPQ---TPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALE----KQRQEYERQ 614
            ..|:   .|..::.:..||      ||..|              ..||:||:    .|||   ..
Human   500 ESPRLTLQPKPVVGHFSAR------ELDGD--------------RSKQLALKVLCVAQRQ---YS 541

  Fly   615 FQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRAN 679
            ..|..|:|:|.               .||......|:..|:..:...|..|.|      .:.|..
Human   542 LLQAANLLTPD---------------MITEFETLQQLVQEEKIEPGAEALRTS------GLARGA 585

  Fly   680 SLVQEANFLAEE----------------------MEKKTKFSV-TLQIPPANLSPNRRRGAFVSE 721
            .|.||   |..|                      |.::....: ||.|||   .||       ..
Human   586 PLAQE---LCSESIPVPSPLCPEPPGYTGPVTRTMARRLSGPLHTLGIPP---GPN-------CT 637

  Fly   722 PAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDP 773
            ||       .||: |.|||               |.|..:.|:.|:  |..|
Human   638 PA-------QGSR-WPMEK---------------KRRRPSALEADS--PMAP 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	154/370 (42%)
		Kinesin_assoc	356..468	CDD:465047	24/127 (19%)
		FHA_KIF13	446..547	CDD:438758	12/100 (12%)
		KIF1B	741..786	CDD:463574	6/33 (18%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	152/360 (42%)
		PHA03247	<606..851	CDD:223021	22/94 (23%)