DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif1b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_038965095.1	Gene:	Kif1b / 117548	RGDID:	621520	Length:	1825	Species:	Rattus norvegicus

Alignment Length:	1956	Identity:	564/1956 - (28%)
Similarity:	830/1956 - (42%)	Gaps:	570/1956 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            |:...:||||||||||.||...::|||::|:...|.:.||    |..::.||:|:||:.::| .:
  Rat     1 MSGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINP----KNPKEAPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--GIIPRLCDQL 127
            |||..||||..|::.:|:.:|.:||:|||.|||||||||:||||||||.||..  ||||:||::|
  Rat    62 PEDPCFASQSRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGKQEESQAGIIPQLCEEL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |..|.:....::.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:||||||.
  Rat   127 FEKINDNCNEDMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYT 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...|..|.:|.||||::|||||||||||
  Rat   191 DIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKQDPETNLSTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSN----GKKSGNDKFVPYRDSVLTWLLKDNLG 318
            ..|||.|.|||||:||||||||||.|||.||:..|    .||.....|:|||||||||||::|||
  Rat   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVLTWLLRENLG 320

  Fly   319 GNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML-- 381
            |||||.|||.:||:..||:|||||||||||||:|..:||:||||||:::|||:.||..|:.:|
  Rat   321 GNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKEEVTRLKDLLRA 385

  Fly   382 ------------------------------KH---------------------ATGSP------- 388
                                          ||                     .|.||
  Rat   386 QGLGDIIDIDPLMDDYSGSGGKYLKDFQNNKHRYLLASENQRPGNFSTASMGSLTSSPSSCSLNS 450

  Fly   389 ------VGDVQ-------------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGIS 434
                  |..:|             ::|.|||.::.::::||||||.|||.|:.||:..|.:||::
  Rat   451 QAGLTSVTSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVA 515

  Fly   435 VQAS----GIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEH 495
            ::..    |:...|...:|||||.||.::|.|:||:||.....|:..:.::.||.|||..|:.||
  Rat   516 IREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADAERRQDIVLSGAHIKEEH 580

  Fly   496 CVITIEDSG-----LYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM- 554
            |:...|.:.     :.:||.:.:..:|||........|::|:||:.|.:|.||.|.|:......
  Rat   581 CIFRSERNNTGEVIVTLEPCERSETYVNGKRVAHPVQLRSGNRIIMGKNHVFRFNHPEQARAERE 645

  Fly   555 CASEPQTPAQLIDYNFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYER 613
            .....:||::.:|:.||:.|:::.: ..|..|....||:      ::.:|:..:.||:||.:||.
  Rat   646 KTPSAETPSEPVDWTFAQRELLEKQ-GIDMKQEMEKRLQEMEILYKREKEEADLLLEQQRLDYES 709

  Fly   614 QFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEK--WAQERDEMFRRSLGQLKT--- 673
            :.|.|:.               .:....:...|...:...|:  |.|...|:.:.:..:.|:
  Rat   710 KLQALQK---------------QVETRSLAAETTEEEEEEEEVPWTQHEFELAQWAFRKWKSHQF 759

  Fly   674 ----DIMRANSL-VQEANFLAEEMEKKTKFSV-----TLQIP-PANLSPNRRRGAFVSEP----- 722
                |::..|:: ::|||.::.|::||.:|..     ||..| |..|.|..........|
  Rat   760 TSLRDLLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPVPPELLPTEMGKTHEDRPFPRTV 824

  Fly   723 -AILVKRTNSG-SQIWTMEKLENKLIDMREMY----------QEHKERVLNGLD----------- 764
             |:.|:...:| :..|:::||:.:|..|||||          |:..|..:.|.|
  Rat   825 VAVEVQDLKNGATHYWSLDKLKQRLDLMREMYDRAGEVGSNAQDDSETTMTGSDPFYDRFHWFKL 889

  Fly   765 ---------------------------------------------EDNA---------------- 768
                                                         :|.|
  Rat   890 VGSSPIFHGCVNERLADRTPSPTFSTADSDITELADEQQDAMEDFDDEAFVDDTGSDAGTEEGSE 954

  Fly   769 ---KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIA----- 825
               ...||||:......|:|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.||
  Rat   955 LFSDGHDPFYDRSPWFILVGRAFVYLSNLLYPVPLIHRVAIVSEKGEVRGFLRVAVQAIAADEEA 1019

  Fly   826 ------------------------GQMPQDRMCES--------VSESSGDSRDEYDDP------- 851
                                    ...|...|..|        :.|..|.|.:....|
  Rat  1020 PDYGSGIRQSGTAKISFDNEYFNQSDFPSAAMTRSGLSLEELRIVEGQGQSSEVISPPEEVNRMN 1084

  Fly   852 ---------------VDPTSNQI----------TCRVTIKCASGLPLSLSNFVFCQYTF-WGHQE 890
                           ::..|.:|          |.|||:..|||:....:: :|||:.| ..|.|
  Rat  1085 DLDLKSGTLLDGKMVMEGFSEEIGNHLKLGSAFTFRVTVLQASGILPEYAD-IFCQFNFLHRHDE 1148

  Fly   891 --MVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWE 953
              ...|:.|     :.:.....|.|.|:..|.:.|.|:::.....:..||:||........:|.|
  Rat  1149 AFSTEPLKN-----NGRGSPLGFYHVQNIAVEVTESFVDYIKTKPIVFEVFGHYQQHPLHLQGQE 1208

  Fly   954 VEQQQAKARSLVDRWAELSRKIE----------------------LWVEIHELNDNGEYSPVEVT 996
            :......:|........|||.:.                      :|.||.||...|||.|..|.
  Rat  1209 LNSPPQPSRRFFPPPMPLSRPVPATKLNTMNKTSLGQSMSKYDLLVWFEISELEPTGEYIPAVVD 1273

  Fly   997 NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEE 1061
            :...:...|.:.|.||.|||:.|
  Rat  1274 HTAGLPCQGTFLLHQGIQRRITV------------------------------------------ 1296

  Fly  1062 DLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGS 1126
              |::.||.||...:       .::.|:....:|:.|.:.                 ..|.|
  Rat  1297 --TIIHEKGSELHWK-------DVRELVVGRIRNKPEVDE-----------------AAVDA--- 1332

  Fly  1127 GIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQH 1191
                                :|.||:    :||::.....|.:.:  .|.|:....||..:
  Rat  1333 --------------------ILSLNI----ISAKSLKSSHSSSRL--FLDKDIPRTFYRFE---- 1367

  Fly  1192 LDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSH---PAPMDLVLRKRLSINIKKG 1253
                    |.||||:|:|..|||||...|::|:.|...:.|.|   ||    |:.|.:.:
  Rat  1368 --------AVWDSSLHNSLLLNRVTPYGEKIYMTLSAYLELDHCIQPA----VITKDVCM----- 1415

  Fly  1254 QTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGD-----------D 1307
             ....|..|....|....::.||.:....||......||    ||.::|.:|.           |
  Rat  1416 -VFYSRDAKISPPRSLRNLFGSGYSKSPDSNRVTGIYEL----SLCKMADTGSPGMQRRRRKVLD 1475

  Fly  1308 CSASDGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDA 1372
            .|.:        |.||    |..|...|.|.:..:.|    |...|.
  Rat  1476 TSVA--------YVRG----EENLAGWRPRGDSLILE----HQWELE------------------ 1506

  Fly  1373 SMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDD-SPGKAFGIAS 1436
            .:|.|..|.::..|. |....||:...                     |..||. ||..:.|..|
  Rat  1507 KLELLHEVEKTRHFL-LLRERLGDSIP---------------------KSMSDSLSPSLSSGTLS 1549

  Fly  1437 PATSKLLGMRMTTLHEEPLGGHRSLDEEPEDSYSDSEY-AAEYEQERQQNKSMATRSRLTASKTM 1500
            .:|| :.....||..|..:        .|.:|   |.| :|:.|....:.|.:||:.....:.|.
  Rat  1550 TSTS-ISSQISTTTFESAI--------TPSES---SGYDSADIESLVDREKELATKCLQLLTHTF 1602

  Fly  1501 D-SFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRS 1564
            : .|..|....:...||..|....:    ..:::.|.|:.|.|.      :|.:|     ...||
  Rat  1603 NREFSQVHGSISDCKLSDISPIGRD----PSVSSFSSSTLTPSS------TCPSL-----VDSRS 1652

  Fly  1565 MSIDE-TPDFD-RVNS--------------NSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQE 1613
            .|:|: ||:.: |.:|              .:|...:|..|.||..:|..:........:||...
  Rat  1653 SSMDQKTPEANSRASSPCQEFEQFQIIPTVETPYLARAGKNEFLNLVPDIEEVRAGSVVSKKGYL 1717

  Fly  1614 AFTHPL 1619
            .|..||
  Rat  1718 HFKEPL 1723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/361 (61%)
		KISc	6..359	CDD:214526	220/359 (61%)
		Kinesin_assoc	356..468	CDD:292801	54/194 (28%)
		FHA	446..546	CDD:238017	37/104 (36%)
		KIF1B	741..786	CDD:289208	18/129 (14%)
		DUF3694	<1196..1252	CDD:289256	21/58 (36%)
		CAP_GLY	1786..1850	CDD:279625
Kif1b	XP_038965095.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	220/361 (61%)
		Kinesin_assoc	358..555	CDD:406567	56/196 (29%)
		FHA	532..636	CDD:238017	37/103 (36%)
		KIF1B	845..892	CDD:403579	11/46 (24%)
		DUF3694	1266..1422	CDD:403614	54/274 (20%)
		PH_KIFIA_KIFIB	1710..1808	CDD:269939	5/14 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820