DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif1c

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_665884.2	Gene:	Kif1c / 113886	RGDID:	70928	Length:	1100	Species:	Rattus norvegicus

Alignment Length:	1291	Identity:	424/1291 - (32%)
Similarity:	585/1291 - (45%)	Gaps:	409/1291 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||...|.||:|.|:...|.:.||    |..:..||:|.||:.::| .:
  Rat     1 MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINP----KQSKDAPKSFTFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..||||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||:|:||:.|
  Rat    62 VEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.:....:.:|.|.|||||||||.|:|.|||:|| ::.||:||||.::||||..||:||||||.
  Rat   127 FSRVNVNQSAQLSYSVEVSYMEIYCERVRDLLNPK-SRGSLRVREHPILGPYVQDLSKLAVTSYA 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...||.||:..||||::|||||||||||
  Rat   191 DIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRSHDQLTGLDSEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLAD-QSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNS 321
            ..:||.|.|||||:||||||||||.|||.||| ||..:||   .|:||||||||||||:||||||
  Rat   256 DSSGARGMRLKEGANINKSLTTLGKVISALADLQSKKRKS---DFIPYRDSVLTWLLKENLGGNS 317

  Fly   322 RTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM------ 380
            ||.|:|.:||:..||||||||||||||.|:|..:||:|||||||:||||:.||..||.:
  Rat   318 RTAMIAALSPADINYEETLSTLRYADRTKQIRCNAVINEDPNARLIRELQEEVARLRELLMAQGL 382

  Fly   381 -------LKHATGSPVG---------------------------------------DVQDKLAES 399
                   ||...|||.|                                       :..::|.|:
  Rat   383 SASALGGLKVEEGSPGGVLPAASSPPAPASPSSPPPHNGELEPSFSPSAEPQIGPEEAMERLQET 447

  Fly   400 ENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV----EKNKYYLVNLNADPSLNE 460
            |.::.::::||||||.|||.::.||:..|.:||::|:..|..|    .|...:|||||.||.::|
  Rat   448 EKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSE 512

  Fly   461 LLVYYLKDRTLIGGRTISGQ-QPDIQLSGLGIQPEHCVITI--EDSG---LYMEPVQGARCFVNG 519
            .|:|::||     |.|..|| ..||:|:|..|:.:||:...  :..|   :.:||.:||..:|||
  Rat   513 CLLYHIKD-----GVTRVGQVDVDIKLTGQFIREQHCLFRSIPQPDGEVMVTLEPCEGAETYVNG 572

  Fly   520 SAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM---CASEPQTPAQLIDYNFARDEIMQNELS 581
            ....|...|::|:||:.|.:|.||.|.|:......   ....|..|::.:|:|||:.|:::
  Rat   573 KLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKELLE---- 633

  Fly   582 NDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNT 646
                         |...|.::.:||:.|:.|.|::
  Rat   634 -------------QQGIDIKLEMEKRLQDLENQYR------------------------------ 655

  Fly   647 PTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLA-----EEMEKKT-------KFS 699
                       :|::|               |:.|:::....|     |:.:|::       ..|
  Rat   656 -----------KEKEE---------------ADLLLEQQRLYADSDSGEDSDKRSCEESWRLISS 694

  Fly   700 VTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLD 764
            :..|:||..:.             .:|||....|        ..|....|.:||..:.|.|.|
  Rat   695 LREQLPPNTVQ-------------TIVKRCGLPS--------SGKRRAPRRVYQIPQRRRLQG-- 736

  Fly   765 EDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMP 829
                  :||.:.:..:..:..|..|..||...|.:   |           ||  .|||.:|. :.
  Rat   737 ------KDPRWATMADLKMQAVKEICYEVALADFR---H-----------GR--AEIEALAA-LK 778

  Fly   830 QDRMCESVS--ESSGD-----SRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWG 887
            ...:|.:..  |..||     :||.:|
  Rat   779 MRELCRTYGKPEGPGDAWRAVARDVWD-------------------------------------- 805

  Fly   888 HQEMVVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHC-------IEGALSIEVWGHRSAG 945
                                            |:.||  |.|       .|||...||...| |.
  Rat   806 --------------------------------TVGEE--EGCGGGGGGGEEGARGAEVEDLR-AH 835

  Fly   946 FSKTKG--WEVEQQQA----KARSLVDRWAELSRKIELWVEIHELNDNGE-----YSPVEVTNRN 999
            ..|..|  .||:.|.:    :.::|.||...:.|.|.|..::.:  ||.|     ::|.|
  Rat   836 IDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLTQDLED--DNEESGLVTWAPPE----- 893

  Fly  1000 EVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLT 1064
                 |...:.:......:..|:|                    |...:|..:| :....|||..
  Rat   894 -----GSEAVEEAVSNDHSPAVRP--------------------SSPPQSSWER-VSRLMEEDPA 932

  Fly  1065 VLREKWSEALGRRRQYLDQQIQM---------------------------LIKKEEKNEQERERE 1102
            ..|       ||.|....:|:::                           |....:.|.|.||
  Rat   933 FRR-------GRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKSNPQHRE-- 988

  Fly  1103 LSLVHQWVSLTEERNAVLVPAPGSG------------IPGAPASWEPPSGMEPHVP 1146
                 .|            |..|||            .|..|.:..|||...||.|
  Rat   989 -----SW------------PGMGSGEAPGPQPPEEVTAPPPPPNRRPPSPRRPHRP 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	221/358 (62%)
		KISc	6..359	CDD:214526	221/356 (62%)
		Kinesin_assoc	356..468	CDD:292801	54/167 (32%)
		FHA	446..546	CDD:238017	40/105 (38%)
		KIF1B	741..786	CDD:289208	9/44 (20%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Kif1c	NP_665884.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	221/358 (62%)
		Kinesin_assoc	352..522	CDD:406567	56/174 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..435		1/36 (3%)
		FHA	499..599	CDD:238017	40/104 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	900..924		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	949..1100		18/98 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820