Protein Alignment Khc-73 and KIF1C

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: NP_006603.2
• Gene: KIF1C / 10749
• HGNCID: 6317
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1285
• Identity: 416/1285 - (32%)
• Similarity: 571/1285 - (44%)
• Gaps: 414/1285 - (32%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||...|.||:|.|:...|.:.||    |..:..||:|.||:.::| .:
Human     1 MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINP----KQSKDAPKSFTFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..||||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||:|:||:.|
Human    62 TEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.::...:.:|.|.|||||||||.|:|.|||:|| ::.||:||||.::||||..||:||||||.
Human   127 FSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPK-SRGSLRVREHPILGPYVQDLSKLAVTSYA 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...||.||:..||||::|||||||||||
Human   191 DIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322
            ..:||.|.|||||:||||||||||.|||.|||..:.|:..:  |:||||||||||||:|||||||
Human   256 DSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSD--FIPYRDSVLTWLLKENLGGNSR 318

  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM------- 380
            |.|:|.:||:..||||||||||||||.|:|..:|::|||||||:||||:.||..||.:
Human   319 TAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLS 383

  Fly   381 ------LKHATGS-------------PVG--------------------------DVQDKLAESE 400
                  ||...||             ||.                          :..::|.|:|
Human   384 ASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETE 448

  Fly   401 NLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV----EKNKYYLVNLNADPSLNEL 461
            .::.::::||||||.|||.::.||:..|.:||::|:..|..|    .|...:|||||.||.::|.
Human   449 KIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSEC 513

  Fly   462 LVYYLKDRTLIGGRTISGQ-QPDIQLSGLGIQPEHC------------VITIEDSGLYMEPVQGA 513
            |:|::||     |.|..|| ..||:|:|..|:.:||            |:|       :||.:||
Human   514 LLYHIKD-----GVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVT-------LEPCEGA 566

  Fly   514 RCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM---CASEPQTPAQLIDYNFARDEI 575
            ..:|||....|...|::|:||:.|.:|.||.|.|:......   ....|..|::.:|:|||:.|:
Human   567 ETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKEL 631

  Fly   576 MQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMG 640
            ::                 |...|.::.:||:.|:.|.|:                      |..
Human   632 LE-----------------QQGIDIKLEMEKRLQDLENQY----------------------RKE 657

  Fly   641 KITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIP 705
            |...:....|.|:...:...|:..:||.    .:..|..|.::|                  |:|
Human   658 KEEADLLLEQQRLYADSDSGDDSDKRSC----EESWRLISSLRE------------------QLP 700

  Fly   706 PANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKP 770
            |..:.             .:|||....|        ..|....|.:||..:.|.|.|
Human   701 PTTVQ-------------TIVKRCGLPS--------SGKRRAPRRVYQIPQRRRLQG-------- 736

  Fly   771 QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCE 835
            :||.:.:..:..:..|..|..||...|.:   |           ||  .|||.:|. :....:|.
Human   737 KDPRWATMADLKMQAVKEICYEVALADFR---H-----------GR--AEIEALAA-LKMRELCR 784

  Fly   836 SVSESSGD-------SRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVV 893
            :..:..|.       :||.:|
Human   785 TYGKPDGPGDAWRAVARDVWD-------------------------------------------- 805

  Fly   894 PVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSK--TKGWEVE- 955
                                      |:.||      ||.      |..|.|.|:  .:|.|||
Human   806 --------------------------TVGEE------EGG------GAGSGGGSEEGARGAEVED 832

  Fly   956 -----------------QQQAKAR---SLVDRWAELSRKIELWVEIHELNDNG---EYSPVEVTN 997
                             |..:|.|   :|.||...:.|.|.|..:..:.|:.|   .::|.|
Human   833 LRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPE--- 894

  Fly   998 RNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQ--- 1059
                          |.:............|...|                    ..||.|::
Human   895 --------------GSEAAEEAAPSDRMPSARPP--------------------SPPLSSWERVS 925

  Fly  1060 ---EEDLTVLREKWSEALGRRRQYLDQQIQM---------------------------LIKKEEK 1094
               |||....|       ||.|....:|:::                           |....:.
Human   926 RLMEEDPAFRR-------GRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKS 983

  Fly  1095 NEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPH 1144
            |.|.||       .|              ||.|...||...:||..:.||
Human   984 NPQHRE-------SW--------------PGMGSGEAPTPLQPPEEVTPH 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	217/357 (61%)
		Kinesin_assoc	356..468	CDD:465047	53/167 (32%)
		FHA_KIF13	446..547	CDD:438758	42/113 (37%)
		KIF1B	741..786	CDD:463574	9/44 (20%)
		DUF3694	989..1243	CDD:463599	31/189 (16%)
		CAP_GLY	1785..1850	CDD:460154
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	217/357 (61%)
		Kinesin_assoc	352..522	CDD:465047	55/174 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..438		2/37 (5%)
		FHA_KIF1C	498..599	CDD:438780	41/112 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	808..828		8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	874..924		11/86 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1103		15/84 (18%)