DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and KIF1C

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_006603.2	Gene:	KIF1C / 10749	HGNCID:	6317	Length:	1103	Species:	Homo sapiens

Alignment Length:	1285	Identity:	416/1285 - (32%)
Similarity:	571/1285 - (44%)	Gaps:	414/1285 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.||...|.||:|.|:...|.:.||    |..:..||:|.||:.::| .:
Human     1 MAGASVKVAVRVRPFNARETSQDAKCVVSMQGNTTSIINP----KQSKDAPKSFTFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..||||:.|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||:|:||:.|
Human    62 TEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQQGIVPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.::...:.:|.|.|||||||||.|:|.|||:|| ::.||:||||.::||||..||:||||||.
Human   127 FSRVSENQSAQLSYSVEVSYMEIYCERVRDLLNPK-SRGSLRVREHPILGPYVQDLSKLAVTSYA 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||::|.||...||.||:..||||::|||||||||||
Human   191 DIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322
            ..:||.|.|||||:||||||||||.|||.|||..:.|:..:  |:||||||||||||:|||||||
Human   256 DSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSD--FIPYRDSVLTWLLKENLGGNSR 318

  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSM------- 380
            |.|:|.:||:..||||||||||||||.|:|..:|::|||||||:||||:.||..||.:
Human   319 TAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEVARLRELLMAQGLS 383

  Fly   381 ------LKHATGS-------------PVG--------------------------DVQDKLAESE 400
                  ||...||             ||.                          :..::|.|:|
Human   384 ASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQIGPEEAMERLQETE 448

  Fly   401 NLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKV----EKNKYYLVNLNADPSLNEL 461
            .::.::::||||||.|||.::.||:..|.:||::|:..|..|    .|...:|||||.||.::|.
Human   449 KIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPHLVNLNEDPLMSEC 513

  Fly   462 LVYYLKDRTLIGGRTISGQ-QPDIQLSGLGIQPEHC------------VITIEDSGLYMEPVQGA 513
            |:|::||     |.|..|| ..||:|:|..|:.:||            |:|       :||.:||
Human   514 LLYHIKD-----GVTRVGQVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVT-------LEPCEGA 566

  Fly   514 RCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSM---CASEPQTPAQLIDYNFARDEI 575
            ..:|||....|...|::|:||:.|.:|.||.|.|:......   ....|..|::.:|:|||:.|:
Human   567 ETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHPEQARLERERGVPPPPGPPSEPVDWNFAQKEL 631

  Fly   576 MQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMG 640
            ::                 |...|.::.:||:.|:.|.|:                      |..
Human   632 LE-----------------QQGIDIKLEMEKRLQDLENQY----------------------RKE 657

  Fly   641 KITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIP 705
            |...:....|.|:...:...|:..:||.    .:..|..|.::|                  |:|
Human   658 KEEADLLLEQQRLYADSDSGDDSDKRSC----EESWRLISSLRE------------------QLP 700

  Fly   706 PANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKP 770
            |..:.             .:|||....|        ..|....|.:||..:.|.|.|
Human   701 PTTVQ-------------TIVKRCGLPS--------SGKRRAPRRVYQIPQRRRLQG-------- 736

  Fly   771 QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCE 835
            :||.:.:..:..:..|..|..||...|.:   |           ||  .|||.:|. :....:|.
Human   737 KDPRWATMADLKMQAVKEICYEVALADFR---H-----------GR--AEIEALAA-LKMRELCR 784

  Fly   836 SVSESSGD-------SRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVV 893
            :..:..|.       :||.:|
Human   785 TYGKPDGPGDAWRAVARDVWD-------------------------------------------- 805

  Fly   894 PVINAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSK--TKGWEVE- 955
                                      |:.||      ||.      |..|.|.|:  .:|.|||
Human   806 --------------------------TVGEE------EGG------GAGSGGGSEEGARGAEVED 832

  Fly   956 -----------------QQQAKAR---SLVDRWAELSRKIELWVEIHELNDNG---EYSPVEVTN 997
                             |..:|.|   :|.||...:.|.|.|..:..:.|:.|   .::|.|
Human   833 LRAHIDKLTGILQEVKLQNSSKDRELQALRDRMLRMERVIPLAQDHEDENEEGGEVPWAPPE--- 894

  Fly   998 RNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQ--- 1059
                          |.:............|...|                    ..||.|::
Human   895 --------------GSEAAEEAAPSDRMPSARPP--------------------SPPLSSWERVS 925

  Fly  1060 ---EEDLTVLREKWSEALGRRRQYLDQQIQM---------------------------LIKKEEK 1094
               |||....|       ||.|....:|:::                           |....:.
Human   926 RLMEEDPAFRR-------GRLRWLKQEQLRLQGLQGSGGRGGGLRRPPARFVPPHDCKLRFPFKS 983

  Fly  1095 NEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPH 1144
            |.|.||       .|              ||.|...||...:||..:.||
Human   984 NPQHRE-------SW--------------PGMGSGEAPTPLQPPEEVTPH 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	217/357 (61%)
		KISc	6..359	CDD:214526	217/355 (61%)
		Kinesin_assoc	356..468	CDD:292801	53/167 (32%)
		FHA	446..546	CDD:238017	41/112 (37%)
		KIF1B	741..786	CDD:289208	9/44 (20%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
KIF1C	NP_006603.2	KISc_KIF1A_KIF1B	4..355	CDD:276816	217/357 (61%)
		Kinesin_assoc	352..522	CDD:318424	55/174 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..438		2/37 (5%)
		FHA	499..599	CDD:238017	41/111 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..828		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..924		11/86 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	950..1103		15/84 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820