DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and Kif19b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	NP_001365608.1	Gene:	Kif19b / 101055939	MGIID:	3646257	Length:	974	Species:	Mus musculus

Alignment Length:	946	Identity:	245/946 - (25%)
Similarity:	403/946 - (42%)	Gaps:	247/946 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KIKVAVRVRPFNRREIELDTKCIVEMEKQQTIL-----QNPPPLEKIERKQPKTFAFDHCFYSLN 64
            ::.||:|:||.|..|:|.....|......|.::     ::|....:..|.:.:||.||..|
Mouse    27 QLMVALRIRPLNSTELEEGATVIAHKVGDQVVVLMDPGEDPEDTLRAHRSRERTFIFDTVF---- 87

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFS 129
               :..||||||:....:.:::....|||..|||||.:|:||::||:|.....||..:....||.
Mouse    88 ---DQHASQETVYCATIQHLVEGVISGYNTTIFAYGPSGAGKTHTMLGVDAEPGIYLQTLTDLFQ 149

  Fly   130 AIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDI 194
            || .::...:.|.|.:||:|||||.:.|||:  |:...|::||.:.....:.|:::::.::.|:|
Mouse   150 AI-EETQDNMEYSVSMSYLEIYNEVIRDLLN--PSSGFLELREDSRGSIQIAGITEVSTSNAQEI 211

  Fly   195 DNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMSLVDLAGSERAV 258
            ..|:|:||:.||...|..|..|||||||..|.:.|  ..:...::.| ::.|:.:|||||||||.
Mouse   212 MQLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVHQ--RSRGGDLAEEVRLGRLFMVDLAGSERAA 274

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            :|...|.|:|||::||:||..||..|:.|:::...:.    ::|.:|||.||.||||.|||||||
Mouse   275 QTQNRGKRMKEGAHINRSLLALGNCINALSEKGGSRA----QYVNFRDSKLTRLLKDALGGNSRT 335

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNED----PNARIIRELRHEVETLRSML 381
            ||:|.|||::.::||:.:||.||.|||.|   |...::|..    ....:|.:||.|:..|:|.:
Mouse   336 VMIAHISPASTSFEESRTTLLYAYRAKNIKTRVKRNLLNVSYRIAQYTDVISDLRREIGHLKSKI 400

  Fly   382 KHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQA----LEKMGISVQASGIKV 442
                     :.|||..:|:..:..|..|......:..|:|..|.:|    ..|..:.::.|.:::
Mouse   401 ---------EKQDKEKKSDPGVLDIQVTIPHDAEEDSRLQMNRIRAQLIGAFKEQMEMRRSLVEL 456

  Fly   443 EKNKYYLVNLNADPSLNELLVY-YLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLY 506
            |...   :.|:.|.|.:.|.:. :.:::|                        |..:.::.....
Mouse   457 ENTN---IELHIDMSRHLLTIADWEREKT------------------------HQHVDVDSGERD 494

  Fly   507 MEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQTPAQLIDYNFA 571
            .|||..                 :|:.:                    .||||...|      .|
Mouse   495 KEPVDA-----------------DGEEV--------------------GASEPPEVA------LA 516

  Fly   572 RDEIMQNELSNDPIQTAI--ARLERQ--HEEDKQVALEK--QRQEYERQFQQLRNILSPSTPYAP 630
            |:|:  |.|..:..:||.  |.||::  |.:.|...:||  .||....:.:::..:|..:
Mouse   517 REEV--NLLLAEQQKTAALKAGLEQRLAHAKQKASQMEKLLPRQVTSEEQREVLQLLCRA----- 574

  Fly   631 YAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSL-------------------------GQ 670
                              .::.||....:.|.:||::|                         .|
Mouse   575 ------------------HELEVENTELQADNLFRKNLLCQKDFVIQRYHQHRLLCEQVIQGQRQ 621

  Fly   671 LKTD--IMRANSLVQEANFLAEEMEKKTKFSVTLQI----------PPANLSP------------ 711
            |..|  |.....|.|:....:.|:.:.|...:.||:          |..|:||
Mouse   622 LMQDNGISAPEPLEQQYRLYSRELGEGTLDRLLLQLSVMSSSLQDGPIMNVSPPPTEESSGEPLG 686

  Fly   712 NRRR---GAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKP--- 770
            :||.   ||....|.:|::|.:.|::       .:|...:|.:.:           :|:..|
Mouse   687 DRRDLPWGATFELPQMLLERDSDGNR-------SSKSTPLRRLGK-----------QDSLLPPPA 733

  Fly   771 -----QDPFYESQENHNLIGVANIFLEVLFHDVKLDYHT--------PIISQQG--EVA-GRLQV 819
                 ..|..|..   |..| |...:..|.....|:..|        |::|.|.  |:| |...:
Mouse   734 LRILLTPPMLEKP---NAPG-AKSLISRLQPTAALELRTQQPAGEMSPLLSAQALKEMALGTKSI 794

  Fly   820 EIERIAGQMPQDRMCESVSESSG--DSRDEYDDPVD 853
            .:      :...|.|:......|  ||||  ..|.|
Mouse   795 AL------IAASRRCKVYDREGGCLDSRD--PSPAD 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	138/362 (38%)
		KISc	6..359	CDD:214526	138/361 (38%)
		Kinesin_assoc	356..468	CDD:292801	24/120 (20%)
		FHA	446..546	CDD:238017	10/100 (10%)
		KIF1B	741..786	CDD:289208	7/52 (13%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
Kif19b	NP_001365608.1	KISc_KIP3_like	27..364	CDD:276821	136/352 (39%)
Kif19b	NP_001365608.1	PHA03307	675..>974	CDD:223039	35/178 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910