DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif28

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_021322979.1	Gene:	kif28 / 100537112	ZFINID:	ZDB-GENE-130530-1027	Length:	1037	Species:	Danio rerio

Alignment Length:	1188	Identity:	358/1188 - (30%)
Similarity:	560/1188 - (47%)	Gaps:	255/1188 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAS-DKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLN 64
            ||| |.:||||||||||:||.:..::||:.|......:|:|.     ..:..:||.||:.::|.:
Zfish     8 MASKDCVKVAVRVRPFNKRERDAGSRCIISMTSNSISIQDPR-----NSQNSRTFTFDYTYWSHS 67

  Fly    65 -----------PEDE--NFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQES 116
                       ||:.  .:|.|.:||..:|:||||||.|||||.:.|||||||||||:|:|...:
Zfish    68 GFSRNKDGLFVPEETGGRYADQASVFLDLGQGILDNALQGYNATLLAYGQTGSGKSYSMVGYGPN 132

  Fly   117 KGIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQS--LKVREHNVMGPY 179
            ||:||.||.:||.:|.:..... ..:|..|.:|||||:|.|||. |.::.:  |:|||....|.|
Zfish   133 KGLIPTLCQRLFQSIRSMQDSR-QCQVFFSMLEIYNEQVVDLLS-KSSRSAGGLRVREDQQTGFY 195

  Fly   180 VDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVS 244
            |:||.::...|...::.||.:|.::||.|||::|..|||||.:..|.|.||.:.:..    .|.|
Zfish   196 VEGLRRVPCDSALQVEQLMEQGTRTRTTAATHINNSSSRSHMLIIVQLKQIFSKECI----TKQS 256

  Fly   245 RMSLVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVL 309
            .:.|||||||||...:|:.|||||||:.||.||||||.|||.|||.:.|||.    ::|||||||
Zfish   257 NIYLVDLAGSERQRSSGSEGDRLKEGTAINLSLTTLGNVISALADMALGKKI----YIPYRDSVL 317

  Fly   310 TWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEV 374
            |.||:..|||||||||:||:||:...|||:|||||||:|||:|.|.|||||.|..|:::||:.|.
Zfish   318 TKLLQSALGGNSRTVMIATLSPADICYEESLSTLRYAERAKKIQNKAVVNESPTERLVKELKAEN 382

  Fly   375 ETLRSMLKHATGSPVGDVQDK-------LAESENLMKQISQTWEEKLVKTERIQNERQQALEKMG 432
            ..|...|.. .|......:|:       |..:|..::.|...||:.|          |:||:..
Zfish   383 AKLLLRLSR-LGQEGRKAEDESKELRRLLTHNELQIRAIQTLWEQHL----------QEALKDW- 435

  Fly   433 ISVQASGIKVEKNKY----YLVNLNADPSLNELLVYYLKDRTL-IGGRTISGQQP-DIQLSGLGI 491
             ..|.:.|..|:...    |::|:|.|..|:.::..::::... ||   ::...| .:.:.||||
Zfish   436 -ETQYATITQERRMMQMYPYIMNVNEDAQLSSVVKLFIQEGEWDIG---LADNSPRALSIRGLGI 496

  Fly   492 QPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCA 556
            |.:|.|.:.:...:.:.||.||:..|||....::|.||:.||::.|           ||:|.:..
Zfish   497 QEKHAVFSNQQRRVSITPVSGAKVIVNGLQVSKRTELQHLDRLVLG-----------SNSTYLFI 550

  Fly   557 SEPQTPA----QLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQ 617
            ..|...:    ...||::              .|:.:|..|..|.:.
Zfish   551 GFPSERSAEDWSRYDYDY--------------FQSELAAAEGFHIQS------------------ 583

  Fly   618 LRNILSPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLV 682
                |.....:.|:.| ||                              ||..:..|.::...:|
Zfish   584 ----LCDDQGHRPHQP-DP------------------------------SLLAVFYDYIKLMPMV 613

  Fly   683 QEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQ---IWTMEKLENK 744
            .|||.::.|::|..:|.:.::    ||:.:..:|..: |..|.||.|:..|:   :|:..|..|:
Zfish   614 TEANQMSAELKKGVEFKLEIK----NLAMSDSKGHDL-EKDIAVKVTSVESKQVWMWSKAKFINR 673

  Fly   745 LIDMREMYQEHKERVLNGLDEDNA---KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPI 806
            ...|.|:||   ::|..|...|.|   :.:|||::..|..:| |.|:::|:.|...:.|:....:
Zfish   674 KFLMEEVYQ---QQVAGGEGADRAPLPRDRDPFWDPLEPLHL-GSAHLWLQSLAFRIPLEEQVEM 734

  Fly   807 ISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGL 871
            :..:|.....||.::      :|    |.....:.|:. |...||.:....::..::.:....||
Zfish   735 VGPEGTEEAILQAQL------VP----CSPAGLALGED-DILIDPSELLGKRLDFQLVLDQCCGL 788

  Fly   872 ---------PLSLSNFVF-CQYTFWGHQEMVVPVINAESTAHDQNMVFKFEHTQDFT-VTINEEF 925
                     .:.:...|| |.      |.:..|.:     .|:.|.:  .:|...|| :..:::.
Zfish   789 RWVKEARNRGVQIGFQVFDCP------QPLYTPAV-----WHNVNPL--LDHRVQFTALRTSQDL 840

  Fly   926 LEHCIEGALSIEVWGHR---SAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVE------- 980
            |.:....||.:|:||.:   |...|...|.::.|:.:   .::|:   :|....|..|
Zfish   841 LNYLQSNALVLELWGLQEGCSELLSNMDGMKMTQEDS---VIIDK---ISASEHLTAETGSSDLS 899

  Fly   981 -----IHELNDNGEYSPVEVTNRNEVL-------TGGIYQLRQGQQRRVNVRVKPVQNSGTLPII 1033
                 :|:..|....:...:...|..|       ..|:...|..|:||           |:|...
Zfish   900 SSLRALHQDLDKLRNANAALKKENSALREQLNSSRNGVENNRGRQERR-----------GSLRPS 953

  Fly  1034 CQS----IVNVAIGSVT-VRSRLQR-----PLDSYQEEDL----------TVLREKWSEALGRRR 1078
            |.:    .:.|...|:| ||.:|||     |   .:||||          |.|.:.:||.|.:..
Zfish   954 CDAEFAKALKVFYHSMTSVRGQLQRLRRHKP---SEEEDLLGLRLFVDEHTFLLKDFSEQLEQCV 1015

  Fly  1079 QYLDQQIQMLI-KKEEKN 1095
            ..|...:..:: :|.||:
Zfish  1016 STLKHDVAAIVRRKREKS 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	179/369 (49%)
		KISc	6..359	CDD:214526	178/367 (49%)
		Kinesin_assoc	356..468	CDD:292801	31/122 (25%)
		FHA	446..546	CDD:238017	28/105 (27%)
		KIF1B	741..786	CDD:289208	14/47 (30%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif28	XP_021322979.1	Motor_domain	14..367	CDD:328930	178/367 (49%)
		FHA	453..551	CDD:238017	31/111 (28%)
		KIF1B	670..708	CDD:315155	12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920