DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif13b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_031758942.1	Gene:	kif13b / 100492799	XenbaseID:	XB-GENE-956968	Length:	1943	Species:	Xenopus tropicalis

Alignment Length:	2026	Identity:	897/2026 - (44%)
Similarity:	1225/2026 - (60%)	Gaps:	248/2026 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTIL--QNPPPLEKIERKQPKTFAFDHCFYSL 63
            |:...:|||||:||.||||::|.|||:|::|..|.:|  .|....:...|.|||.||:||||:|:
Frog     1 MSDSTVKVAVRIRPMNRREVDLQTKCVVDVENNQIVLYPSNASLSKGDARSQPKVFAYDHCFWSM 65

  Fly    64 NPE-DENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQL 127
            :.. .|.||.|:.||.|:|..||.|||:|||||||||||||||||||||||.:..|:|||||..|
Frog    66 DESVKEKFAGQDVVFQCLGENILQNAFEGYNACIFAYGQTGSGKSYTMMGTADQPGLIPRLCSTL 130

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            |.........||.:|||||:||||||||.||||||.::||||||||.|:||||||||:||||||:
Frog   131 FERTQKAENEELSFKVEVSFMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSKLAVTSYK 195

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||::||:||||||||||||||.|||||||||:::||..|.|..:|.||||||::|||||||||||
Frog   196 DIESLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLVDVKSGTSGEKVSKLSLVDLAGSERA 260

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSR 322
            .||||.|:||||||||||||||||||||.||||..||  ..:||||||||||||||||:|||||:
Frog   261 TKTGAAGERLKEGSNINKSLTTLGLVISALADQGAGK--NKNKFVPYRDSVLTWLLKDSLGGNSK 323

  Fly   323 TVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGS 387
            |.||||:||:||||:|||||||||||||.||||||||||||||||||||.|||.||..|..|...
Frog   324 TAMVATVSPAADNYDETLSTLRYADRAKNIVNHAVVNEDPNARIIRELREEVEKLRVQLTQAESM 388

  Fly   388 PVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNL 452
            ...:::::|.|||.|:::::.||||||..||.|..|||:.||.:|||:|:|||||..||.:||||
Frog   389 KAPELKERLQESEKLIQEMTVTWEEKLRMTEDIAQERQKQLESLGISLQSSGIKVGDNKSFLVNL 453

  Fly   453 NADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSG-LYMEPVQGARCF 516
            ||||:|||||||||||.||||    |....||||.||||.||||:|.|...| :.:.|::..|.:
Frog   454 NADPALNELLVYYLKDHTLIG----SHDSQDIQLCGLGILPEHCIIDISPEGQVILTPMKNTRTY 514

  Fly   517 VNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKS---------------NNTSM--------CASE 558
            |||||..:.|.||:||||||||:||||::.||.               |::|.        .:||
Frog   515 VNGSAVTKATQLQHGDRILWGNNHFFRISLPKKKKAKQEDEEQDSSLRNSSSFEQLDLDGDSSSE 579

  Fly   559 PQTPAQLIDYNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNIL 622
            ..:... .:|.:|:.|||...| :|||:|:.:..||:||||:|:.|||:||..||.:..|||..|
Frog   580 GSSEVN-FNYEYAQMEIMMKALGNNDPMQSILQSLEQQHEEEKRSALERQRLMYEHELDQLRRRL 643

  Fly   623 SPSTPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANF 687
            ||...:  |...|....|     :|.:|.|:.:|.:||:.|..:||.:|:..|.:||..||||||
Frog   644 SPEKQH--YRSMDRFSFG-----SPNAQQRIRQWTEEREAMLNQSLRKLREQIAKANLHVQEANF 701

  Fly   688 LAEEMEKKTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMY 752
            :||||:|:|::.||||||.::|:.|::|||.:|||||.|:|...|.|||::|||||:|:|:|::|
Frog   702 IAEEMDKRTEYKVTLQIPASSLNANKKRGAVLSEPAIQVRRKGKGKQIWSLEKLENRLVDIRDLY 766

  Fly   753 QEHKERVLNGLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQG 811
            ||.||     .|||:.      :..||||:..|||:||||||:|||.|||||||.|..|||:|:|
Frog   767 QEWKE-----CDEDDPMSRSYFRRADPFYDEHENHSLIGVANVFLESLFHDVKLQYAVPIINQKG 826

  Fly   812 EVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLS 876
            ||||||.||:.||:|.: :||:      :.|:...::....:...|::.|.:.:..|:|||..|:
Frog   827 EVAGRLHVEVVRISGDI-EDRI------AGGEDGADFSFEKEAQENKLVCMIKVLQATGLPQHLT 884

  Fly   877 NFVFCQYTFWGHQE--MVVPVIN-AESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEV 938
            |||||.|.||...|  .|.|.:: |.........:..|:|.::|.|.|.|:|||:..||||:|||
Frog   885 NFVFCHYIFWDQPEPTTVAPEVDTAPPVIKGTECMVVFDHCKEFVVNITEDFLEYLSEGALAIEV 949

  Fly   939 WGHRSAGFSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVL 1002
            :|||.:...:... |::...|||.|||.|||:|::||:||||:|.|||:||||.|||||...:|.
Frog   950 YGHRQSDPHRNPALWDLGIIQAKTRSLRDRWSEVTRKVELWVQILELNENGEYCPVEVTPAKDVQ 1014

  Fly  1003 TGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTV-----------RSRLQRPLD 1056
            |||||||:|||.||:::..:.||:|||||:|..||::::||.|.:           ....:..:|
Frog  1015 TGGIYQLKQGQSRRLHIEARSVQDSGTLPLIEDSILSISIGCVKIVNAKAIKAHDFHQDAREDVD 1079

  Fly  1057 SYQEEDLTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLV 1121
            |||:.||..||.||..||.:|::|||||:|.|:.|::|:|.:.:||..|:...::||||||||:|
Frog  1080 SYQDRDLERLRRKWLNALTKRQEYLDQQLQKLVSKQDKSEDDADREAQLLEMRLTLTEERNAVMV 1144

  Fly  1122 PAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTL 1186
            |:.|||||||||:|.|.||||.|:||:||:||.||.|:|:..|.|..||.:|.|:.|...:|:.|
Frog  1145 PSAGSGIPGAPANWTPVSGMETHIPVIFLDLNVDDFSSQDDLDGLEPAGWDSTLTSEDEGEFFDL 1209

  Fly  1187 QILQHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIK 1251
            ||::|.:.:|...||||.::|:...|::.:...:||:||:|.||:|||||.|.:|||||:.:|:.
Frog  1210 QIVKHHESEVKAEASWDCTVHNCPQLSKGSAPEDRVFLIVRATVQLSHPAEMQIVLRKRICVNVY 1274

  Fly  1252 KGQTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETY 1316
            ..|......  .|.:...::|...|||.|||||||:.|:..||||:||::||:.:|..::|.|.|
Frog  1275 SRQGFAQSF--LRRMSHRSSISSCGVTVEVVSNIPEDSQGAEDREALARMAANVEDTGSADSEAY 1337

  Fly  1317 IEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESL---- 1377
            ||||.|.|.|||:|||||||||.|||||..|..|:  ..||::|.||   :.|...|.:.|
Frog  1338 IEKYLRSVLAVENILTLDRLRQEVAVKEQLTGKGK--LHRKSLSSPN---VHRLSGSRQDLGGQQ 1397

  Fly  1378 ---LNVGRSESFADLN-NSALGNKFTPAGHS--PAGAGGVIRSRHSFGGKGSSDDSPGKAFGIAS 1436
               .|.||.||..|:: .|.:.::...:|||  |.................:|..||.|:.   .
Frog  1398 SLASNKGRWESQQDVSQTSPVPSRAVVSGHSSLPKMVPQYQLQESGLANMATSYLSPVKSL---V 1459

  Fly  1437 PATSKLL----------GMRMTTLHEEP----LGGHRSLDEEPE----------DSYSDSEYAAE 1477
            |...|||          |.:.:.|.::.    :....|:||.|.          .:......|..
Frog  1460 PQMPKLLKSLFPQRDEKGRQSSPLSQQTVPRIMVQSASVDENPAVPKMVPLEEWKNVRPPVIARS 1524

  Fly  1478 YEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSS 1542
            ..||::..::.|..|   ..|..|..:..:..|..|.||..||  ....|....|||  |...|:
Frog  1525 PGQEKKMERAPAVPS---PPKVPDPPVPETQESPPSPLSEASS--GYFSHSVSTATL--SEVLSA 1582

  Fly  1543 GYGSQAVSCN----------------NLSNEDIASMRS-----------MSIDETPDFDRVNSNS 1580
            |...| :|.:                |.|..|:.::.:           ..:|.:.|.:|.:...
Frog  1583 GNEVQ-ISVHPPTPTAADRHAGPPPTNPSGSDVLNLETTQPVNGSVSHEFKLDVSQDPERTSIAK 1646

  Fly  1581 PPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHP----LEQLESSQNAQ-----SDDDECA 1636
            .||.        |::.:.: .::.|.:...|.||.|.|    .|.|..|.|.:     :...|.|
Frog  1647 GPNS--------KELDEGR-GDRTEHRKPLLSEASTEPHGENTESLSPSDNVEQTGSATSTSEQA 1702

  Fly  1637 QLPKNNNNNLDLVNEPKPLSSQTDLEE-------SMSQPKSKTEFATDNQNGNRSSDELSHSSED 1694
            ::.::      |.....||.:..|::.       |..:|.|:|:
Frog  1703 EVHRS------LATTELPLPTSEDIQRATPCKPFSTPEPLSQTK--------------------- 1740

  Fly  1695 LLEGDGIVREELPAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDS 1759
                 |:|       ...:.:|..|....:...:..:..|....|     ::..|::|:|  ||:
Frog  1741 -----GVV-------SPFKIQKVRTSELKSFTRMLGDELGEVGKP-----SAAVKLKGVA--LDN 1786

  Fly  1760 SIMTSSTEVDEESKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGK 1824
               |:..:.:....|....:|||:..||.|.:.. |.:|::|:||..:||.|.|:||||:||.||
Frog  1787 ---TADKQEEVSDSDEPQEVPEWLKEGEYVTVGS-NKNGIVRYVGPADFQEGVWVGVELETPAGK 1847

  Fly  1825 NDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKAAEKSNSISKEMSTSMT---GSMTRS 1886
            |||||.|..||:|.|.:|:.||.::|               :|::..::..||.:.   |::|.|
Frog  1848 NDGSVGGKHYFRCNPGYGVLVRPNRL---------------KKASGAARRRSTGLRLQGGTVTES 1897

  Fly  1887 KSRGDSLNLSA 1897
            : :|.:|:.||
Frog  1898 R-KGANLSGSA 1907

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	250/357 (70%)
		KISc	6..359	CDD:214526	250/355 (70%)
		Kinesin_assoc	356..468	CDD:292801	70/111 (63%)
		FHA	446..546	CDD:238017	62/100 (62%)
		KIF1B	741..786	CDD:289208	23/50 (46%)
		DUF3694	<1196..1252	CDD:289256	26/55 (47%)
		CAP_GLY	1786..1850	CDD:279625	33/63 (52%)
kif13b	XP_031758942.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	250/357 (70%)
		Kinesin_assoc	357..469	CDD:406567	70/111 (63%)
		FHA	449..544	CDD:238017	61/98 (62%)
		KIF1B	755..801	CDD:403579	23/50 (46%)
		DUF3585	<1097..1141	CDD:419985	20/43 (47%)
		DUF3694	<1185..1277	CDD:403614	38/91 (42%)
		CAP_GLY	1810..1873	CDD:396049	33/63 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	496	1.000	Domainoid score	I365
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9073
Inparanoid	1	1.050	1592	1.000	Inparanoid score	I82
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm49472
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080