DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and LOC100491511

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_031749449.1	Gene:	LOC100491511 / 100491511	-ID:	-	Length:	2330	Species:	Xenopus tropicalis

Alignment Length:	2000	Identity:	538/2000 - (26%)
Similarity:	831/2000 - (41%)	Gaps:	526/2000 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE--KIERKQPKTFAFDHCFYSLNPED- 67
            ::|||||||.|:||.|.....::.|...:||||:...:.  |:: |.||.|.:||||:|.:..|
Frog     7 VRVAVRVRPMNQREKEKHPVGVISMSGTKTILQSNATVSPGKVQ-KGPKEFTYDHCFWSADDSDP 70

  Fly    68 ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIA 132
            :.:|.||.||..:..|.::|.:||||.||||||||||||:|||||..:..|:|||.|..|.:. .
Frog    71 DTYAGQEEVFKTLEEGTIENIYQGYNVCIFAYGQTGSGKTYTMMGRDDEPGLIPRFCRALLNR-K 134

  Fly   133 NKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDNL 197
            :|.|    .:||:||||||||||.|||:.|.:|:.|.|||||::||||:||||.||::::||..|
Frog   135 SKGT----VRVELSYMEIYNEKVRDLLELKKSKKELSVREHNILGPYVEGLSQHAVSTWEDIKLL 195

  Fly   198 MTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKTGA 262
            :..|||.||.|||.||.|||||||:|::.:||:..:||:|.|.|..|:.:||||||||||.|:||
Frog   196 LLAGNKCRTTAATKMNEESSRSHAIFTLAITQMFPNQASGTSKELHSKFNLVDLAGSERASKSGA 260

  Fly   263 VGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVMVA 327
            .|.:|.|..|||||||:||.:||.|| :..|::|.:  :|.||:||||||||::|||||:|||:|
Frog   261 QGKQLVESGNINKSLTSLGRIISSLA-ECKGRRSSS--YVSYRESVLTWLLKNSLGGNSKTVMLA 322

  Fly   328 TISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVGDV 392
            ||||:.|||.||.|||.||:||::|||.|.||||...:.:..|:.||:.|:..||.|......::
Frog   323 TISPAEDNYGETHSTLVYAERARKIVNQATVNEDTKCKAVATLQKEVQNLKEQLKRAKSQQSPEL 387

  Fly   393 QDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPS 457
            |.||.|||||:||::.:|||||.|||......|:.||.|||||.|||||..|.:..|||||.||.
Frog   388 QSKLKESENLLKQLNLSWEEKLKKTEENAKLMQKYLESMGISVDASGIKCAKEQCCLVNLNPDPE 452

  Fly   458 LNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITI-EDSGLYMEPVQGARCFVNGSA 521
            .|:.|:|||.|...||    :|...|.||:|.||:.||||||: .|..:::.|.......|||:.
Frog   453 SNDYLLYYLTDHNKIG----AGSSQDFQLTGPGIEEEHCVITMTPDGDVFLVPSTKTETKVNGAL 513

  Fly   522 AVEKTPLQNGDRILWGNHHFFRVNSPK--------------------SNNTSMCASEPQTPAQLI 566
            ..|...|.:.|:|..|.::.|.:|.||                    :::.|:..|.|:..:.:.
Frog   514 VQESIQLYHEDKINLGLNYSFILNQPKKRQPNSLSENKHKVEKNEMSTDHESINESNPKHESGIQ 578

  Fly   567 D----YNFARDEIMQNELSN----DPIQTAIARLERQHEE------DKQVALEKQRQEYERQFQQ 617
            :    |..:..:...|||:.    :|.:..|:...|.|:.      :|.:||.::.||...:.||
Frog   579 EQHPYYQLSGSQDDDNELTKTFHINPKKEEISTESRSHDSHSTSSIEKVLALLQKSQESLTELQQ 643

  Fly   618 -----------------------------------LRNILSPSTPYAPYAPYDPLRMGKITPNTP 647
                                               |.||::.....|.....|.|...|:..|..
Frog   644 NFTNLVEKLESKQLITQQDCAGLENKEDVVLKYEILLNIIAEKGENACTEFLDLLGKDKVDMNKD 708

  Fly   648 TSQMRVEKWAQ------------ERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKTKFSV 700
            ....|.|:..:            :::|:..:   :..|:.:...|.|.:....||..|:.|.
Frog   709 NDDDRKEQNTETETAKDQSQPNNDKNEVAEK---EETTEALNEKSDVAKTENGAEREEENTG--- 767

  Fly   701 TLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLNGLDE 765
                |..|.|.|               .|...|:....|  ||..||.:.:|::..:::
Frog   768 ----PSKNHSDN---------------DTKKNSEDECTE--ENTSIDKKTLYRDLLKKM------ 805

  Fly   766 DNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQ 830
                ..||:  ..:|..|..:..|..|.|   .|:|..     |:...|.....:|..:.|...
Frog   806 ----NMDPY--EMKNLTLQDILQIDQECL---EKMDNW-----QRKSAAMNFIHKIIALNGTAR- 855

  Fly   831 DRMCESVSESSGDSRDEYDDPVDPTSN--------QITCRVTIKCAS-------GLPLSLSNFVF 880
                ..::.|..:|.|..|||.|.|.:        .:.|.| :.|:.       .|.:|:..|..
Frog   856 ----SIITSSENESEDSQDDPDDVTCDSSDSVHPLDVLCLV-LHCSDLFLQQEIILKMSMCQFAV 915

  Fly   881 -----------CQYTFWGHQEMVV---PVINAESTAH-DQNMV------FKF------------- 911
                       |.:..||.:::|.   |...||:..: .:|:|      |.|
Frog   916 PFLLPAVDGPGCTFMLWGMRDIVKRWRPQSLAETKGYMQENLVQISMPTFSFVRFGESKLSKSTI 980

  Fly   912 --------EHTQDFTVTINEE---FLEHCIEGALSIEVWGHRSAG----------FSKTKGWEVE 955
                    :.||||.|..|.|   ......||.:.|..:.....|          |:...|
Frog   981 LNQVLSPTQQTQDFFVHSNMEGADVTREISEGLVEISWYFPAGKGNSDIFPEPVAFANLHG---- 1041

  Fly   956 QQQAKARSLVDRWAELSR-KIELWVEIHELNDN--GEYSPVEVTNRNEVLTGGIYQLRQGQQRRV 1017
                ..:..::.:|.|:: ...:::.:.::|.|  ...|..|.:..|.|:   |::    ..|::
Frog  1042 ----NLKDSLNEFAFLTQISSTVFIFVQDINKNLIDFLSQYENSQANFVI---IFK----DSRKI 1095

  Fly  1018 NVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWSEALGRRRQYLD 1082
            :      :::|...:......:.|.|: |:..:::.....:
Frog  1096 D------KDTGLTNVTVVHFNSKASGA-TIAKKIRAATTDF------------------------ 1129

  Fly  1083 QQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPV 1147
                  |||       :.|.|||                                 ..|....|.
Frog  1130 ------IKK-------KFRALSL---------------------------------EDMAEIAPK 1148

  Fly  1148 LFLNLNGDDLSAQNTN-DELSVAG-INSILSKEHGHKFYTLQILQH------LDKDVCCVASWDS 1204
            |.::::.:.:..||.. |..::|. |..:..    :|..|:::.:|      |:|::|.:.....
Frog  1149 LRISVDENVIECQNAKADAKAIADEIKDVAE----YKKDTMRLQRHLWKKAELEKEMCQMKKQGD 1209

  Fly  1205 SMHD---SQALNRVTEANER--VYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQT-LTDRLKKF 1263
            ...|   |:...:..|..|:  .|.|..:..:..|..             :||..| ::..||..
Frog  1210 KRTDSYKSELQKQCAEIREKQFKYEIPNSISKFIHSV-------------VKKNYTEISYFLKWL 1261

  Fly  1264 RLVRGENAIWQSGVTYEVVSNIPKASEELEDRE---SLAQLAASGDDCSASDGETYIEKYTRGVS 1325
            |..          :......|:.....|.:::.   |::....||.|...||....||.:.|.:.
Frog  1262 RFY----------LDLSARKNLFALQAEYKEKSVPASMSSKELSGLDQKISDSSLGIEHFLRELG 1316

  Fly  1326 AVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFS----------QIMRFDAS---MESL 1377
            ....       .::...||   .:|   |.||...:|.|:          :::..|||   |:.|
Frog  1317 QFYE-------AEHCKFKE---ENG---SERKFTKLPAFAADLLLGGFPLELIDGDASNIPMQWL 1368

  Fly  1378 LNVGRSESFADLNN-----SALGNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSPGKAFGIASP 1437
            .:|     ..:|:|     |.:| ..|..|....|...::.:                .||:..|
Frog  1369 QDV-----LTELDNKTGKCSRMG-VITVLGVQSTGKSTLLNT----------------MFGLQFP 1411

  Fly  1438 ATSK--LLGMRMTTL-----HEEPLGGHRSL--DEE----PE-----DSYS-DSEYAA------- 1476
            .:|.  ..|..||.:     .:|.||....|  |.|    ||     |||. |:|.|.
Frog  1412 VSSGRCTRGAFMTLMKVRKDFQEELGCEFILVIDTEGLKAPELASLKDSYEHDNELATLAVGLSD 1476

  Fly  1477 --------EYEQERQQNKSMATRSRLTASK---------TMDSFMDVSSHSNQ--------SYLS 1516
                    |...|.:....:...:.|...:         ...:..|||:|.|.        ..|:
Frog  1477 ITIVNMAMENTTEMKDILQIVVHAFLRMKEIGRKPKCHFVHQNVSDVSAHENNRRDRMKLLEQLN 1541

  Fly  1517 YTSSANANMK---HLTGLATLSMSSSTSSGY-------GSQAVSCNNLS-NEDIASMRSMSIDET 1570
            ..:...|:|:   ..|..:.:.|.......:       |...::..|:: :|.|..:::..|:
Frog  1542 EMTKIAADMEKKTKFTAFSDIMMYDPEKDNFYIPGLWNGVPPMASINIAYSETIYELKTYLIE-- 1604

  Fly  1571 PDFDRVNSNSPPNRQARVNPFLK----------------DMPKAKIQEQPEQQAKKLQE---AFT 1616
                     ...|:..|:..|::                ....:.:.....|.|||..|   .||
Frog  1605 ---------CMKNKGHRIGDFIEWIESLWSAVKYENFIFSFKNSLVANAYNQLAKKYSELEWKFT 1660

  Fly  1617 HPL-------EQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTDLEESMSQ------- 1667
            ..:       |.:..:||||:.|.|.|   |..|....:::|.:. ..:.:||:..|.
Frog  1661 KAMHKWLAETETVIKNQNAQTIDSEGA---KCKNAAYSILSEEEE-RMKKELEKYFSSENKDASL 1721

  Fly  1668 -PKSKTEFATDNQNGNRSSDELSHSSEDLLEGDGIVREELPAGKVVRRKK 1716
             .:.|.||.|......|..:..|.|..|  |...|.:|.|...||:...|
Frog  1722 VERYKAEFLTSASCLRRKLEASSLSKCD--EAIRIQKENLKVKKVISAYK 1769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	196/355 (55%)
		KISc	6..359	CDD:214526	196/355 (55%)
		Kinesin_assoc	356..468	CDD:292801	56/111 (50%)
		FHA	446..546	CDD:238017	39/100 (39%)
		KIF1B	741..786	CDD:289208	9/44 (20%)
		DUF3694	<1196..1252	CDD:289256	8/60 (13%)
		CAP_GLY	1786..1850	CDD:279625
LOC100491511	XP_031749449.1	Motor_domain	5..354	CDD:419868	196/355 (55%)
		Kinesin_assoc	<384..463	CDD:406567	44/78 (56%)
		FHA	466..528	CDD:395400	24/65 (37%)
		PRK08581	544..>796	CDD:236304	47/278 (17%)
		CARD	641..701	CDD:260018	8/59 (14%)
		P-loop_NTPase	1387..>1516	CDD:422963	27/144 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010