DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Khc-73 and kif18b

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_002939283.3	Gene:	kif18b / 100490953	XenbaseID:	XB-GENE-5960389	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	969	Identity:	264/969 - (27%)
Similarity:	410/969 - (42%)	Gaps:	243/969 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLE--------------KIERKQPKTFAF 56
            :.|.|||||.|:||.|.:...:|::.....::.:|...|              |.:.|..| |.|
Frog    13 VSVVVRVRPPNQREQEGNHHAVVQVVDHNMLVFDPDEPETTGVFSSLRGNDGPKRKGKDMK-FIF 76

  Fly    57 DHCFYSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIP 121
            |..|      .|| :.|:.||:...:.|||....|||..:||||.||:||::||:|::...|::.
Frog    77 DRIF------GEN-SRQQDVFEHTTKEILDGVLNGYNCSVFAYGATGAGKTHTMLGSEADPGVMY 134

  Fly   122 RLCDQLF---SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGL 183
            ....:|:   .||..:.:.|::    :||:|:|||::.|||:|   :.||.:||....|..|.||
Frog   135 LTMVELYRRIEAIKEEKSCEVL----ISYLEVYNEQIQDLLEP---RGSLAIREDPQKGVVVQGL 192

  Fly   184 SQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMS 247
            |.....|...:..::..||.:||...|:.||.||.|||||.:.:.|  .|:...:|.: :|::||
Frog   193 SFHQPKSADQLLQMLASGNLNRTQHPTDANASSSHSHAVFQIYVKQ--QDRTVSISQDVRVAKMS 255

  Fly   248 LVDLAGSERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWL 312
            |:||||||||..|.|.|:||:||:|||:||..|..||:.||| :..||:    .:|||||.||.|
Frog   256 LIDLAGSERASTTNAKGERLREGANINRSLLALINVINALAD-AKSKKA----HIPYRDSKLTRL 315

  Fly   313 LKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIREL 370
            |||::|||.||||:|.|||||.:|::|.:||:||:|||.|   :...|:|.|.:    |.:..||
Frog   316 LKDSIGGNCRTVMIAAISPSALSYDDTYNTLKYANRAKEIKLSMKSNVINLDCHISKYAAVCEEL 380

  Fly   371 RHEVETLRSMLK--HATGSPVGDVQDKLAESENLMKQISQTWEEK-------------LVKTERI 420
            :.||..||..|:  .....|..|..|     .:|..:.|...||.             |:.|...
Frog   381 KAEVAELREKLRFYEMKEQPDDDTSD-----NSLQDKTSPRREEHSDLGSPEQGSGALLLSTSSC 440

  Fly   421 QNERQQALE-------KMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTIS 478
            |::..:..|       ::.::......::|||          |.|:|.|.....:|.:.......
Frog   441 QSQDHKPAEMNPRKWDQVPLNCSLGREELEKN----------PCLHEALKDDAAERLVTSLLNFV 495

  Fly   479 GQQPDI-QLSGLGIQPEHCVITIEDSGLYME--PVQGARCFVNGSAAVEKTPLQNGDRILWGNHH 540
            .:|.:| :|:|| ..||     :||....:|  .::|.:      |..||...:.
Frog   496 RKQCEILKLAGL-YTPE-----LEDELRQLEGLALRGQK------ATAEKVTEKE---------- 538

  Fly   541 FFRVNSPKSNNTSMCASE-PQTPAQLIDYNFARDEI--MQNELSNDPIQTAIARLERQHEEDKQV 602
              :|.......|.....| ||||       ...|.:  ::.|:..||:..|..|
Frog   539 --QVTEEHEMETHKEQEEVPQTP-------LVEDVVFDIKEEVIEDPVPPARKR----------- 583

  Fly   603 ALEKQRQEYERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPT--------SQMRVEKWAQE 659
               |..:.|.      .:||..::| :..:|..|::..:...||||        |...|:.....
Frog   584 ---KPGKRYR------ADILPDNSP-SLRSPIVPVKRRREATNTPTKARLAGVPSTPEVQVKRPR 638

  Fly   660 RDEMFRRSLGQLKTDIMRANSLVQEANFLAE--------------EMEKKTKFSVTL-------- 702
            :..:..|....|::.:   |.|...|..:|.              :.:..||..:.|
Frog   639 KSSIPSRCRVSLRSSL---NLLPSNAKDIASQPPSLCTPKQTAKIQSQTVTKSRMPLGTSAIQNC 700

  Fly   703 -QIPPANLSPN--------RRRGAFVSE------------------PAILVKRT---NSGSQIWT 737
             .:|.|.|:|.        ...|.||||                  |...:..|   :|...:::
Frog   701 ASVPAAALAPRDMNTTFDLSEEGCFVSEMDKTVTFGTSDFPGWENVPIHNIDTTFGKSSDVAVFS 765

  Fly   738 MEKLE------NKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLIGVANI----FLE 792
            ::.|.      |::....:.| .||.|                ..|..:.:..|...:    ...
Frog   766 VKGLSVNHMNANQMTSAAKSY-SHKRR----------------RSSSSSMSRAGKGTLAQSRIAR 813

  Fly   793 VLFHDVKLDYHTPIIS---------QQGEVAGRLQVEIERIAGQMPQDRMCE--SVSES 840
            :....||.....|.||         |.|:..|:..|...|....:|..|..:  :||:|
Frog   814 LQMSTVKKSQQPPTISESICSSPRGQSGKKTGKGTVAFGRSLAAVPVTRFTQYSTVSKS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	151/373 (40%)
		KISc	6..359	CDD:214526	151/373 (40%)
		Kinesin_assoc	356..468	CDD:292801	29/137 (21%)
		FHA	446..546	CDD:238017	20/102 (20%)
		KIF1B	741..786	CDD:289208	7/50 (14%)
		DUF3694	<1196..1252	CDD:289256
		CAP_GLY	1786..1850	CDD:279625
kif18b	XP_002939283.3	KISc_KIP3_like	23..355	CDD:276821	143/353 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910