DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and stard9

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_012824730.2	Gene:	stard9 / 100489699	XenbaseID:	XB-GENE-995220	Length:	3979	Species:	Xenopus tropicalis

Alignment Length:	2275	Identity:	524/2275 - (23%)
Similarity:	875/2275 - (38%)	Gaps:	622/2275 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-----RKQPKTFAFDHCFYSLNP 65
            ::||:||||.::||.....:.|:.::.:...::|.....|.:     |::...|.||.|::|::|
Frog     4 VRVALRVRPPSKRETAEGARIILNVDDKVARIKNIRLDHKSDGCGDVRERLMEFGFDSCYWSVDP 68

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            ||..:||||.||..:|..:|..|..|||.|:||||||||||:||||||..|.|:.||:|:.|||
Frog    69 EDPKYASQEVVFQDLGTLVLSEAISGYNVCLFAYGQTGSGKTYTMMGTPASIGLTPRICEGLFS- 132

  Fly   131 IANKSTPEL--MYKVEVSYMEIYNEKVHDLLDPKPNKQ--SLKVREHNVMGPYVDGLSQLAVTSY 191
             .::.:||.  ..:.|||::|||||:|.|||.....|:  :|:||||...||||.||||..||||
Frog   133 -YDEGSPEAPNSCRTEVSFLEIYNERVRDLLHKSEQKKPYTLRVREHPERGPYVQGLSQHVVTSY 196

  Fly   192 QDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSER 256
            :.:..|:.||.::|..|||:::..||||||:|::..||.:.:.  .:..|..|:::|||||||||
Frog   197 EQVVALLEEGMENRITAATHIHDASSRSHAIFTIQYTQAMLED--NLPTEITSKINLVDLAGSER 259

  Fly   257 AVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQ--------------------SNGKKSG---- 297
            | ......|||.||||||:||.|||:|||.||..                    |.|..||
Frog   260 A-SPEYCKDRLTEGSNINRSLVTLGIVISTLAQNSQMTSSCQSINSIASDGDSGSQGSPSGGSMN 323

  Fly   298 ---NDKFVPYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVN 359
               ...:||||||:|||||||:|||||:|:|:||:||::.:|.||:||||||..||.|||...||
Frog   324 GSKRQPYVPYRDSILTWLLKDSLGGNSKTIMIATVSPASSSYNETMSTLRYASHAKNIVNKPRVN 388

  Fly   360 EDPNARIIRELRHEVETLRSMLKH---ATGSPV------GDVQDKLAESENLMKQISQTWEEKLV 415
            ||.|.::||:||.|:..|::||:.   .|.||.      |:..:.:.::|..::|:::.|.||
Frog   389 EDANVKLIRDLREEINRLKNMLQSFEIRTISPSFSDEKDGNFTELVKQNELKIEQLTKDWTEK-- 451

  Fly   416 KTERIQNERQQALEKMGISVQ--ASGIKVEKNKYYLVNLNADPSLNELLVYYLKDRTLIGGRTIS 478
                 ..::...:|:..:.:.  .:|:.::.|..:|:.::.|.....:::|.||:.....||..|
Frog   452 -----WGDKAAIMEQYNVDINQGKAGLTIDSNLPHLITMDDDILSTRVVIYQLKEGQTNIGRFDS 511

  Fly   479 GQQPDIQLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFR 543
            .|:.||.|.|..|:.:||:|......:.::||.||:|.:||........|..||.::.|..|.||
Frog   512 EQEQDIVLQGEWIERDHCMIHNCSGAVELQPVPGAQCTINGQEVTGSCRLSQGDVLIIGKTHRFR 576

  Fly   544 VNSP----------KSNNTSMCASEPQTPAQLIDY-----NFARDE-----IMQNELSNDPIQTA 588
            .|:|          ..:..|..:|..      :|:     ||:...     |:..:|.::..|..
Frog   577 FNNPAEAAVLRQRRSDSQVSFVSSNS------LDWLDLSGNFSTSTNENPLILNRKLESEEYQQK 635

  Fly   589 IARLERQHEEDKQVALEKQRQEY----ERQFQQLRNILSPSTPYAPYAPYDPLRMGKITPNTPTS 649
            :..||..:::..|     |:|.|    ::|.|                               ||
Frog   636 LKDLEGYYQQQVQ-----QQQLYVEDLKKQIQ-------------------------------TS 664

  Fly   650 QMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQE-ANFLAEEMEKKTKFSVTLQIPPANLSPNR 713
            ::|.||              :|:.:....|.:::| ..:|.:|.::.||..:..:...|...|..
Frog   665 KIRSEK--------------ELELEQSLINQIIEENRQWLVKEEQQLTKSHLQRRDSSAQTDPKP 715

  Fly   714 RRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQE----------HKERVLNGLDEDNA 768
            ...|.|...|....|.::.       :|:.|.:..||:.::          .::|:...| |...
Frog   716 IAEAEVQNTAETENRPSAA-------ELDRKRLVQRELLRKCSLRRAERNIRRKRIKFQL-ERII 772

  Fly   769 KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRM 833
            |.|......:|..:|..|..|..:.:.....||...|...........|....:.:.......|.
Frog   773 KKQKLLEAKKELQHLQAVCWISEDTVKQLQNLDSDGPAKGLTHFRPSALPRSFQTLPNLSILKRN 837

  Fly   834 CE-SVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVIN 897
            || :||..|....:| ..|....|  :.| ::..|.|||
Frog   838 CEPAVSLHSNKPSNE-KKPRRAVS--VEC-LSSTCCSGL-------------------------- 872

  Fly   898 AESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKAR 962
            ...|.:|...:.:....:.|....|:.          ....:|.....::         |.:|.|
Frog   873 QSETPNDHQCIVQGVEKRPFGSITNQN----------KQSTYGKFVCAYT---------QMSKKR 918

  Fly   963 SLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQLRQGQQRRVNVRVKPVQNS 1027
            ..:|:....|:.    .....|.......|:..||.                   :.:||..::|
Frog   919 QKMDKTGSRSKS----KTTEPLKRRNSRIPIATTNS-------------------DTKVKSFRSS 960

  Fly  1028 GTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWS---------EALGRRRQYLDQ 1083
            ..     ||:.:..      :|.||...::.::.:.||.:...|         :..||....|
Frog   961 PQ-----QSLESCR------KSTLQENKNTLEKNEATVKKNTKSIPKTITSGKKTAGRSTSTL-- 1012

  Fly  1084 QIQMLIKKEEKNEQERERELSL----------VHQWVSLTEERNAVLVPAPGSGIPGAPASWEPP 1138
                       ...:|:.:|.|          :.:..|.|:..|.:..|.|...|.....|.|..
Frog  1013 -----------KASKRDADLCLKNINKKPANGLAKICSSTDSINTLSRPTPTHAIDKRWQSTERL 1066

  Fly  1139 S-GMEPHVPVLFLNLNGDDLSAQNTN------DELSVAGINSILSKEHGHKFYTLQILQHLDKDV 1196
            | |:.....|||.:...:|.:..:.:      |.||.| ..|.|:|:...|...:       |:|
Frog  1067 SRGLLKPKEVLFEDCKEEDETGSSESESFYSVDSLSSA-FGSALTKDLNWKKLAI-------KNV 1123

  Fly  1197 CC---VASWDSSMHDSQALNRVT---EANERVYLILRTTV--------RLSHPAPMDLVLRKRLS 1247
            .|   ..|.||.|.......|.|   :.|.|.:...:|.:        .:..|.|:.||:...::
Frog  1124 ACKNNSDSEDSEMSQDSLAERGTKREKPNRRRFNNYKTVLTPCSSSKDMVEDPNPLPLVMGTSIT 1188

  Fly  1248 INIKKGQTLTDRLKKFRLVRGENA-------------IWQ------SGVTYEVVSNIPKASEE-- 1291
            ..:.|..:|..      |...|:.             .|:      ||:..|..:||.....|
Frog  1189 TGLSKSFSLDS------LADAEDVPEMDSSEEMPAEIFWKLQSPRISGLQTEDQNNISSTEAENS 1247

  Fly  1292 -------------------------LEDRESL---AQ------------------LAAS----GD 1306
                                     |.:|:.:   ||                  ||||    ..
Frog  1248 SDKGLSNSFYLNVNPLFALDCSDAVLSNRDGINPQAQTNMDDVVSGELENSCPPDLAASALWESQ 1312

  Fly  1307 DCSAS------DGETYIEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFS 1365
            ||:.:      :|.|.|.:    ......:.|...::.|....|     |.....|..:.:||
Frog  1313 DCTITSANNKCEGSTIISE----TELPNQVSTKYSIKNNQCPVE-----GTVKGSRVNLPLPN-- 1366

  Fly  1366 QIMRFDASMESLLNVGRSESFADLNNSALGNKFTPAGHSPAGAGGVIRSRHSFGGK-----GSSD 1425
            :.:..:.:.....|..| ||...:.::|..:.|....:.     |.::.:...|.|     ...|
Frog  1367 ENVEPETTAPECTNEQR-ESNCQILDAAANSDFKDLQYL-----GPLKDQLKAGEKVVLKCSVKD 1425

  Fly  1426 DS-----PGKAFGI----------ASPATSKLLG----------MRMTTLHEEPLGGHRSLDEEP 1465
            :|     |....|:          .:|.|.||.|          :::||::.:.......|..:
Frog  1426 ESRALKDPDICIGLPTANHEDTSGPTPGTGKLKGGIVKEILPTRLKITTVNAKKSPNKMKLTRK- 1489

  Fly  1466 EDSYSDSEYAAEYEQERQQNKSMATRSRLTASKTMDSFMDVSSHSNQSYLSYTSSANAN------ 1524
            ||:   .|...:.:|.......:....:.....:..||.......:.::.:|.::...:
Frog  1490 EDT---KEIRLQMKQSNDLTPDVICNQKEKCEPSTLSFHVTQGSGDTNHYNYHTTEGTSDQQDKY 1551

  Fly  1525 -------------MKHLTGLATLSMSSSTSSGYGSQAVSCNNLSNEDIASMRSMSIDETPDFDRV 1576
                         :||:..|..|.          :.||| |.|..||:.|:.::.::.:|... |
Frog  1552 DTEVAKPMPNCEQLKHIDSLEPLF----------NPAVS-NVLEVEDLDSLENLKMELSPQIS-V 1604

  Fly  1577 NSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAF-THPLEQLESSQNAQS------DDDE 1634
            :.|                 |.:...:|.:..|.:..:| |.|..:|:.:.|.::      ::||
Frog  1605 DGN-----------------KLEKPAEPCELQKLIPSSFYTSPHIELDLNANEENCKKCGIENDE 1652

  Fly  1635 CAQLPKNNNNNL----DLVNEPKPLSSQTDLEESMSQPKSKTEFATD------NQNGNRSSDELS 1689
            |       :|.:    :.:||   .|..|.:|:.|..|.:.:.|..:      .:..:.:.::::
Frog  1653 C-------DNGITEGREYLNE---RSGSTRVEDIMMVPDNHSHFNVNPCVDKCRKQPSLAQEKIT 1707

  Fly  1690 HSSEDLL-------------EGDGIVREELPAGKVVRRKKSNT----QPPS-------------- 1723
            ..:.||.             :|.|...|.:  |.|.:..:.||    :|.|
Frog  1708 PIASDLALDVKIKRNDLETGQGSGFTEEAM--GSVQQNMEDNTPRLHEPKSTNTLLLTNSRDLTF 1770

  Fly  1724 NGNSINNNNNGTT---------QAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEESKDVELVL 1779
            |...:.|::|..|         ::.:.....|...:|....:...|...||..::......|.|.
Frog  1771 NPTKLANDSNFITNVNLKDAKKESDKAGDGVSFVSVESDHCFTIPSPAASSDTLNSNVSGTETVS 1835

  Fly  1780 PEWIVVGESVLIRPYNTSGVIRFVGTT---EFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKH 1841
            |.....|:..::. .:||...:..|::   .|..||.|.|         |.::          |.
Frog  1836 PALTDSGQKTVMF-QSTSSFTKSTGSSLLPSFNEGACIQV---------DNNI----------KD 1880

  Fly  1842 GMFVRSDKLML--------DKRGKAMRAYKAAEKSNSISKEMSTSMTG----------------- 1881
            ..|.:||..||        ::|.:.|.. :|..|. .:|:|:...:|.
Frog  1881 NTFRQSDADMLSLVENISKERRERVMDG-EAVTKP-KLSEEIMLQVTNEQVNLLAPVKNHCSVPE 1943

  Fly  1882 SMTRSKSRGDSLNLSARKXLYPKCSHQLQRWTNCRQSTVATSSQP---ATCHRLRATSGAADANS 1943
            .||.||:....|.....| .:               |..|.:..|   ..|..::...|.||:.|
Frog  1944 QMTGSKNEDCELKGKNEKEKF---------------SVDAQTESPLEKMACSTIKGAVGMADSMS 1993

Fly 1944 1943
Frog 1994 1993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	178/388 (46%)
		KISc	6..359	CDD:214526	178/388 (46%)
		Kinesin_assoc	356..468	CDD:292801	29/122 (24%)
		FHA	446..546	CDD:238017	31/99 (31%)
		KIF1B	741..786	CDD:289208	11/54 (20%)
		DUF3694	<1196..1252	CDD:289256	15/69 (22%)
		CAP_GLY	1786..1850	CDD:279625	14/66 (21%)
stard9	XP_012824730.2	KISc_KIF1A_KIF1B	2..388	CDD:276816	178/388 (46%)
		FHA	479..579	CDD:238017	31/99 (31%)
		SbcC	<628..>789	CDD:223496	38/218 (17%)
		SRPBCC	3775..3977	CDD:417480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920