DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif13a

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_009291008.1	Gene:	kif13a / 100331282	ZFINID:	ZDB-GENE-090901-1	Length:	1937	Species:	Danio rerio

Alignment Length:	2029	Identity:	958/2029 - (47%)
Similarity:	1254/2029 - (61%)	Gaps:	287/2029 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIE-RKQPKTFAFDHCFYSLN 64
            |:..|:||||||||.|||||||:|||:||||..||:|..||...|.| |||||.|||||||:|::
Zfish     1 MSDTKVKVAVRVRPMNRREIELNTKCVVEMEDNQTVLHPPPSNAKGESRKQPKVFAFDHCFWSMD 65

  Fly    65 PED-ENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLF 128
            ..: ..:|.||.||.|:|.|||.|||||||||||||||||||||::|||:.:..|:|||||..||
Zfish    66 ESNIPKYAGQEVVFKCLGEGILQNAFQGYNACIFAYGQTGSGKSFSMMGSGDQPGLIPRLCCSLF 130

  Fly   129 SAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQD 193
            ..::.:.:....:||||||||||||||.||||||.::||||||||.|:||||||||||||||::|
Zfish   131 ERVSTQQSDSNSFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVREHKVLGPYVDGLSQLAVTSFED 195

  Fly   194 IDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAV 258
            |::||:||||||||||||||.|||||||||||:|||.|.|..:|.||||||::||||||||||..
Zfish   196 IESLMSEGNKSRTVAATNMNEESSRSHAVFSVILTQTLYDLQSGNSGEKVSKISLVDLAGSERVS 260

  Fly   259 KTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRT 323
            ||||.|:||||||||||||||||.|||.|||||.||  ..:||||||||||||||||||||||:|
Zfish   261 KTGAAGERLKEGSNINKSLTTLGCVISALADQSAGK--SRNKFVPYRDSVLTWLLKDNLGGNSKT 323

  Fly   324 VMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSP 388
            .|:|||||:|||||||||||||||||||||||||||||||||||||||.|||.||..|..|....
Zfish   324 AMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELREEVEKLREQLSQAESLK 388

  Fly   389 VGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLN 453
            ..::|:||.|||.|:::::.||||||.|||.|..|||:.||.||||:::|||||.::|.:|||||
Zfish   389 APELQEKLQESEKLIQEMTVTWEEKLRKTEEIAQERQKQLESMGISLESSGIKVGEDKSFLVNLN 453

  Fly   454 ADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITI-EDSGLYMEPVQGARCFV 517
            |||:|||||||||||.|.:|..|..    ||||.|:|||.||||:.: .|..:.:.|...||..|
Zfish   454 ADPALNELLVYYLKDHTRVGADTTQ----DIQLFGIGIQSEHCVLEVTADGDVTLTPAHNARTCV 514

  Fly   518 NGSAAVEKTPLQNGDRILWGNHHFFRVNSPK----------SNNTSMCASEPQTPA-----QLID 567
            ||.....|..:.:||||||||:||||||.|.          |...|...::.:|.:     |...
Zfish   515 NGMMVYSKVHVWHGDRILWGNNHFFRVNLPNRKRRKDLDRGSPRESFIEADVETASEASSEQDYS 579

  Fly   568 YNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSP--STPYA 629
            |.||:.|:|...| :|||:|.|:..||:|:.|:|::|||:||..|||:.|.||..|:|  :|.:.
Zfish   580 YEFAQMEVMMKALGNNDPMQNAVQALEKQYVEEKRLALEEQRLMYERELQSLRQQLTPERNTQHQ 644

  Fly   630 PYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEK 694
                       :::.||..:..|:..|.:||||:||:||.:|:..::|||:||:|||||:|||:|
Zfish   645 -----------RLSYNTHNTHSRLRLWTEERDELFRQSLSRLREQVVRANALVREANFLSEEMQK 698

  Fly   695 KTKFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERV 759
            .|.:..|||||.||||.||:|||.||||||.|:|...|:|:||:|||||||:|||:.|::.:|..
Zfish   699 HTDYQATLQIPAANLSANRKRGAIVSEPAIQVRRKGKGTQVWTIEKLENKLVDMRDHYRDWREGA 763

  Fly   760 LNGLDEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERI 824
            ...::..:.|..|||||:|||||||||||:|||.|||||:|.|..|||||||||||||.||:.|:
Zfish   764 QELVNRLHNKAGDPFYEAQENHNLIGVANVFLECLFHDVRLQYAVPIISQQGEVAGRLHVELLRV 828

  Fly   825 AGQMPQDRMC------ESVSESSGDSRDEYDDPVDPTSNQITCRVTIKCASGLPLSLSNFVFCQY 883
            :|.:| :|:|      |:.|||||....:.:..:...:.::||||.||.||||||.|||||||||
Zfish   829 SGAVP-ERLCGGDDSSENSSESSGYDFMDNNGEIVHMARKLTCRVRIKEASGLPLHLSNFVFCQY 892

  Fly   884 TFWGHQEMVV--PVINAE---STAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRS 943
            :||...|..|  |:::.:   :.:|||....:|.|.:||.|.:.|||||...:|||:|||||||.
Zfish   893 SFWDQSEPTVAPPLVSPDTPTARSHDQEFTVRFNHCRDFVVQVTEEFLEFISDGALAIEVWGHRY 957

  Fly   944 AGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQ 1008
            .|..::. ||....|||.|:|.|||:|:||.|||||.|.|||:.||||.||:.|..:..|||::|
Zfish   958 TGNGRSV-WETHTLQAKKRTLRDRWSEVSRSIELWVSIQELNEQGEYSSVELHNTKDSSTGGVFQ 1021

  Fly  1009 LRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRS-RLQRPL----------DSYQEED 1062
            ||||..||:.|.|:|||:|||||::.:::::|:||.||.|| :|||||          |||||||
Zfish  1022 LRQGHSRRLQVCVQPVQHSGTLPLLVEAVLSVSIGCVTARSTKLQRPLDSYQEEDGDMDSYQEED 1086

  Fly  1063 LTVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSG 1127
            |..:|::||:||.:||:||::||::::.|.||:|::.|||..||.|||.|||||||||||||.||
Zfish  1087 LNCVRDRWSDALIKRREYLEEQIKIILNKPEKSEEDIEREARLVEQWVGLTEERNAVLVPAPASG 1151

  Fly  1128 IPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELS---VAGINSILSKEHGHKFYTLQIL 1189
            ||||||.|.||:|||.|:|||||:||.|:|:   .||.|:   .||:||||.||||..|:.|.|:
Zfish  1152 IPGAPAHWVPPAGMEAHIPVLFLDLNADNLT---VNDHLTGPHAAGVNSILPKEHGSSFFYLPII 1213

  Fly  1190 QHLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINIKKGQ 1254
            :|.|.:|..|.|||||:|||..|||:|.||||||||::..|:|||||.::|:||||:::||...|
Zfish  1214 RHSDDEVSAVCSWDSSIHDSIHLNRITAANERVYLIVKAAVQLSHPACVELLLRKRIAVNIYNKQ 1278

  Fly  1255 TLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETYIEK 1319
            :.|..||  |.:..:|.::..|||||:||||||||||.|:||:||.:||.|::....||||||||
Zfish  1279 SFTQSLK--RRMSLKNMLYSCGVTYEIVSNIPKASEEPEERETLALMAARGENEETRDGETYIEK 1341

  Fly  1320 YTRGVSAVESILTLDRLRQNVAVKELETAHGQPLSMRKTVSVPNFSQIMRFDASMESLLNVGRSE 1384
            |||||..|::||.||||||.|.|||..:|.|:  .:|:::|.||    ::..:|.:|....|..:
Zfish  1342 YTRGVLEVDNILCLDRLRQAVTVKEALSAKGK--HIRRSLSTPN----VQHSSSCKSDGRTGCED 1400

  Fly  1385 SFADLNNSAL-------GNKFTPAGHSPAGAGGVIRSRHSFGGKGSSDDSP----GKAFGIASPA 1438
            ....::....       |.:.||           ::||.:.|     .:||    ..||...||.
Zfish  1401 EDVKVSEQTTQCDALPDGTEDTP-----------VKSRENAG-----VESPAFFSSAAFKTLSPQ 1449

  Fly  1439 TSK----LLGMR-----MTTLHEEPLGGHRSL--------------------------------- 1461
            |.|    ||.::     ..||...||.|.:|:
Zfish  1450 THKFIKSLLPLKEEEKTRRTLEARPLLGQQSMRVCMSGPRGPRPRAQSEGRSAGDIIISGSANHS 1514

  Fly  1462 -----------DEEPEDSYSDSEYAA--------------------EYEQERQQNKSMAT----- 1490
                       |.|.:|...||.:..                    |:......|.|:.|
Zfish  1515 TDLTHTLPHTADSEEDDPGMDSAFTCSNVPALGSLELQNFKPYIPEEFANFEIYNASLETQEGAL 1579

  Fly  1491 --RSRLTASKTMDSFMDVSSHSNQSYLSYTSSANANMKHLTGLATLSMSSSTSSGYGSQAVSCNN 1553
              ||.||:...|              ||.|.:|.   |.::...|   :||.:|||.|.  |.:|
Zfish  1580 CARSELTSGIGM--------------LSGTRAAE---KEVSRSPT---ASSCTSGYFSH--SASN 1622

  Fly  1554 LSNEDIASMRSMSIDETPDFDRVNSNSPPNRQAR---------VNPFLKDMPKAKIQEQPEQQAK 1609
            .:..|:....|.|.|:      :|...|.:.|..         .:.|   .|...|..||
Zfish  1623 ATLSDVLFSGSDSCDQ------LNIREPTDSQEHGKGCHSSRSASGF---CPAQIIPSQP----- 1673

  Fly  1610 KLQEAFTHPLEQLESSQNAQSDDDECAQLPKNNNNNLDLVNEPKPLSSQTD--LEESMSQPKSKT 1672
                 ::|.|           .|.:|:..|. ..:.|.:..|........|  .|:::.....|.
Zfish  1674 -----YSHYL-----------TDRDCSPSPP-RKSMLSISQEFTDFKGADDGVEEDALGHFGCKA 1721

  Fly  1673 EFATDNQNGNRSS------------DELSH----------SSED--LLEG--DGIVREEL----- 1706
            |.|:.::..|:||            |.:.|          |.||  |.:|  ||:|.:.|
Zfish  1722 ESASQDKTQNKSSPSKCRLQNGKDEDSVPHVPPEATREIESLEDPELFKGADDGLVEDGLGSFGC 1786

  Fly  1707 PAGKVVRRKKSNTQPPSNGNSINNNNNGTTQAPRINHRASVAKMEGLAAYLDSSIMTSSTEVDEE 1771
            .|..|.:.|..:...||..:..|.........|.:...|:    :.:.::.|..::..|:| ||.
Zfish  1787 KAESVPQAKIQDRSSPSQCHLHNGKQFSGDSVPHVQPEAT----QEIESFEDPELLEDSSE-DEN 1846

  Fly  1772 SKDVELVLPEWIVVGESVLIRPYNTSGVIRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQ 1836
            :...:  ||:|:..||.|.:.  ..||::.:||..||..|.|:|||||...||::|:|||..||:
Zfish  1847 APVAQ--LPDWMAPGEQVWVG--KQSGMVHYVGGVEFAKGIWVGVELDLAVGKHNGTVKGRVYFR 1907

  Fly  1837 CKPKHGMFVRSDKL 1850
            |...||:||:..:|
Zfish  1908 CATGHGVFVKPSRL 1921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	264/356 (74%)
		KISc	6..359	CDD:214526	263/354 (74%)
		Kinesin_assoc	356..468	CDD:292801	72/111 (65%)
		FHA	446..546	CDD:238017	56/100 (56%)
		KIF1B	741..786	CDD:289208	23/44 (52%)
		DUF3694	<1196..1252	CDD:289256	35/55 (64%)
		CAP_GLY	1786..1850	CDD:279625	29/63 (46%)
kif13a	XP_009291008.1	KISc_KIF1A_KIF1B	5..359	CDD:276816	264/355 (74%)
		KISc	6..359	CDD:214526	263/354 (74%)
		Kinesin_assoc	356..468	CDD:292801	72/111 (65%)
		FHA	448..543	CDD:238017	55/98 (56%)
		KIF1B	745..790	CDD:289208	23/44 (52%)
		DUF3585	<1098..1142	CDD:304905	24/43 (56%)
		DUF3694	<1211..1279	CDD:289256	38/67 (57%)
		CAP_GLY	1859..1921	CDD:279625	29/63 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1564	1.000	Inparanoid score	I87
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	1	1.000	-	-		FOG0002517
OrthoInspector	1	1.000	-	-		otm26193
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	LDO	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870