DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif13bb

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_009299747.1	Gene:	kif13bb / 100317281	ZFINID:	ZDB-GENE-090908-5	Length:	2095	Species:	Danio rerio

Alignment Length:	2185	Identity:	897/2185 - (41%)
Similarity:	1221/2185 - (55%)	Gaps:	401/2185 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKI----ERKQPKTFAFDHCFYSLN-P 65
            :||||||||.||||.:|.|||:||||..||||.  |....:    .|.:||.||:|:||:|:: .
Zfish    12 VKVAVRVRPMNRRERDLKTKCVVEMEGNQTILY--PASGNLGKGDSRAKPKCFAYDYCFWSMDEA 74

  Fly    66 EDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSA 130
            |...||.|:.||.|:|..:||:|||||||||||||||||||||||||:.|..|:|||||..||..
Zfish    75 ETGKFAGQDVVFQCLGESLLDSAFQGYNACIFAYGQTGSGKSYTMMGSSEQPGLIPRLCSSLFER 139

  Fly   131 IANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQDID 195
            ...:......:.|||||||||||||.||||||.::|:||||||||:||||||||:|||:||:||:
Zfish   140 SVLEQREGESFTVEVSYMEIYNEKVRDLLDPKGSRQALKVREHNVLGPYVDGLSRLAVSSYKDIE 204

  Fly   196 NLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERAVKT 260
            :||:||||||||||||||.|||||||||:::||..|.|..||.||||||::|||||||||||.||
Zfish   205 SLMSEGNKSRTVAATNMNEESSRSHAVFNIILTHTLRDMKTGTSGEKVSKLSLVDLAGSERADKT 269

  Fly   261 GAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTVM 325
            ||.|:|||||||||:||||||||||.||:|..||  ...||||||||||||||||:|||||||.|
Zfish   270 GAAGERLKEGSNINRSLTTLGLVISALAEQGAGK--NKSKFVPYRDSVLTWLLKDSLGGNSRTAM 332

  Fly   326 VATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATGSPVG 390
            ||.:||:||||||||||||||||||.|:||||||||||||||||||.|||.|||.|..|......
Zfish   333 VAAVSPAADNYEETLSTLRYADRAKSIINHAVVNEDPNARIIRELREEVEKLRSQLSEAESMKAP 397

  Fly   391 DVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNAD 455
            :::::|.|||.|:::::.:|||||.|||.|..|||:.||.:|||:|:|||:|...|.:|||||||
Zfish   398 ELKERLEESEKLIQEMTVSWEEKLRKTEEIAQERQKQLESLGISLQSSGIRVIDEKCFLVNLNAD 462

  Fly   456 PSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIE-DSGLYMEPVQGARCFVNG 519
            |:||||||||||:.|.:|    |....||||.||.||||||:|.|: ::|:.:.|.:.||..|||
Zfish   463 PALNELLVYYLKEHTRVG----SADSQDIQLCGLAIQPEHCIIDIKPETGVTLTPKRNARTCVNG 523

  Fly   520 SAAVEKTPLQNGDRILWGNHHFFRV---NSPKSNNTSMCASEPQTPAQLID-------------- 567
            :.......|.:||||||||:||||:   |..:..:...|..:....:..:|
Zfish   524 AVVSSAIQLHHGDRILWGNNHFFRISVSNVYRVEDEDGCVMKAGLRSDHLDVDRLSLASSDTSFS 588

  Fly   568 YNFARDEIMQNEL-SNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPSTPYAPY 631
            :..|:.|:|...| :|||:|:.:..|||:|||:|:.|||:||..||::.||||..||........
Zfish   589 FESAQTEVMMKALGNNDPMQSVLHSLERRHEEEKRSALERQRLMYEQELQQLRKRLSSELQTQSS 653

  Fly   632 APYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAEEMEKKT 696
            .|.......::..:..:||.|:.:|..:|:.:..|||.:|:..|::||.|||||.|:||::.|||
Zfish   654 HPQHHRSSEQLNASALSSQSRLRQWTDDREVLMSRSLRKLREQIVKANLLVQEAGFIAEDLNKKT 718

  Fly   697 KFSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEKLENKLIDMREMYQEHKERVLN 761
            ::.||||||.|||:.||:|...:|||||.|:|...|.|||.:||:||:|:|||::|||.|:
Zfish   719 EYKVTLQIPAANLNANRKRDTVLSEPAIEVRRKGKGKQIWALEKIENRLVDMRDLYQEWKD---- 779

  Fly   762 GLDEDNA------KPQDPFYESQENHNLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVE 820
             .|||:.      |..|||::.||||:||||||:||..|.::|||.|..|||:|:|||:|||.||
Zfish   780 -YDEDDPAMRSYFKRADPFFDEQENHSLIGVANVFLSCLLYEVKLQYAVPIINQKGEVSGRLHVE 843

  Fly   821 IERIAGQMPQDRMCESVSESSGDSRDEYDDP-VDPTSNQITCRVTIKCASGLPLSLSNFVFCQYT 884
            :||::|         .:.||..|:.|..:.| .:....:.||.:.:..|:|||..|||||||||.
Zfish   844 VERLSG---------GLEESETDTGDSENSPESEMQERKFTCMIKVLQATGLPQHLSNFVFCQYH 899

  Fly   885 FWGHQE--MVVPVI--NAESTAHDQNMVFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAG 945
            ||...|  .:.|.:  :|.|:...|::|. |::.:...|.:.|:|.|..:|||:::||:||:...
Zfish   900 FWDQPEPVFIAPEVGLSAASSREPQSLVV-FDNCKTLEVAVTEDFQEFLMEGAVAVEVYGHKQEN 963

  Fly   946 FSKTKG-WEVEQQQAKARSLVDRWAELSRKIELWVEIHELNDNGEYSPVEVTNRNEVLTGGIYQL 1009
            ..:... |::...|||.|||.:||:|::|::||||::.|:||.|.:.||||....:|.||||:||
Zfish   964 PRRNLALWDLGVIQAKTRSLRERWSEVTRRLELWVQVLEINDTGVFVPVEVQPAKDVCTGGIFQL 1028

  Fly  1010 RQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRL-----------QRPLDSYQEEDL 1063
            :|||.|||:|.|:.||:|||||:|.:|::::::|:|.|:...           .:.:|||||.||
Zfish  1029 KQGQSRRVHVEVRSVQDSGTLPLIAESVLSISMGNVEVQQARTAKSTDTQRVGDKDMDSYQEVDL 1093

  Fly  1064 TVLREKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGI 1128
            ..||.||..||.:|::||||::|.|:.|:.|:|::.|.|..|:...::||||||:||||:.||||
Zfish  1094 ERLRAKWLTALTQRQEYLDQRLQKLVSKQNKSEEDVESESQLLECRLTLTEERNSVLVPSAGSGI 1158

  Fly  1129 PGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDELS---VAGINSILSKEHGHKFYTLQILQ 1190
            |||||.|.|..|||.|:||:||:||.|||     :|.||   ..|::::|.:|....|..|||::
Zfish  1159 PGAPAEWVPVPGMETHIPVIFLDLNADDL-----HDHLSPPLAGGLDAVLKREDKEDFIDLQIVK 1218

  Fly  1191 HLDKDVCCVASWDSSMHDSQALNRVTEANERVYLILRTTVRLSHPAPMDLVLRKRLSINI--KKG 1253
            |.:.:|...||||.::|||..|||.|..::||||.:.|||.|||||.|.||||||:.:|:  ::|
Zfish  1219 HYENEVKAEASWDCTVHDSPELNRATGQDQRVYLTVSTTVLLSHPAQMQLVLRKRICVNLTGRQG 1283

  Fly  1254 --QTLTDRLKKFRLVRGENAIWQSGVTYEVVSNIPKASEELEDRESLAQLAASGDDCSASDGETY 1316
              |:|..|:....|:.|      .|||:|:|||||...:..||||.||:||.|.|:..| |.|..
Zfish  1284 FAQSLLKRMSHRSLIHG------CGVTFEIVSNIPGDMQGSEDREMLARLATSTDNPGA-DSEAA 1341

  Fly  1317 IEKYTRGVSAVESILTLDRLRQNVAVKELETAHGQ-PLSMRKTVSVPN------------FSQIM 1368
            ||||.|.|.|||:|||||||||.|:|:|..|..|: |   ::.:|.||            .||.|
Zfish  1342 IEKYLRSVLAVENILTLDRLRQEVSVREHLTDKGKIP---KRCLSSPNVHRLSGSKKDLSISQDM 1403

  Fly  1369 ---------RFDASMESLLNVGRSESFA-DLNNSALG------NKFTPAG--------------- 1402
                     |.|.|:.:.|...:|.|.: ..:||..|      :.|:|..
Zfish  1404 EDYKGGWDSRQDISVPTSLPKSKSHSSSVQSHNSEPGLSGLAASYFSPVKALVSPVPKMFKSLLS 1468

  Fly  1403 --------HSPA-------------------GAGGVIRSRHSFGGKGSSDDSPG----------- 1429
                    .|||                   |:.|::.|..|......:...|.
Zfish  1469 KKDEKKDLPSPAAFQQNVPRIVVQSVSLEDIGSSGLVCSTPSEDAAQCNQSEPAAFVPIFPVIPA 1533

  Fly  1430 -----KAFGIASPATSKLLGMRMTTLH----EEPLGGHRSLDEE---------------PEDSYS 1470
                 ||..|.|..||   ..:..:||    |.|:..:....||               |.....
Zfish  1534 GVENTKASTIFSETTS---DNKRVSLHSHAIETPVSENSENSEEILPKVLPTKLSAEVLPPSVSQ 1595

  Fly  1471 DSEYA------AEYE-------QERQQNKSMATR------SRLT--ASKTMDSFMDV-------- 1506
            :.|.|      .|.|       |:.:::...:|:      |.::  ..:.:.||:.:
Zfish  1596 EVEKALPLCISQELEVLPSSVCQDIEEDLPSSTKVEEVLCSSISTKVDEDLPSFVSLKDGGVLPP 1660

  Fly  1507 -----------------------SSHSNQSYLSYTSSANANMKHLT------------------- 1529
                                   ||.|.:...|..||.::.::..|
Zfish  1661 TVSPVVREDTPLSLPPEFEEARHSSVSPEVEESLPSSVSSEVREGTPVFDSSEVVEAELPPVSSK 1725

  Fly  1530 --------------------GLATLSMSSSTSSGYGSQAVSCNNLSN----EDIASMRSMSIDET 1570
                                |.:|.|..|..||||.|.:||...||.    .|.|.:.|..
Zfish  1726 IEEVPPLGPVEIEDPKQSPVGDSTNSSISDVSSGYISTSVSTATLSECAALNDPAPLNSTE---- 1786

  Fly  1571 PDFDRVNSNSPPNRQARVNPFLKDMPKAKIQEQPEQQAKKLQEAFTHPLEQL-ESSQNAQSDDDE 1634
               |:|:...|...:|:.:..:.......:::|     .||:.|.....||: .:||.::....|
Zfish  1787 ---DKVDKPVPKKTEAKADDMIVPNSSTSLEQQ-----LKLEPAHPEHGEQIFAASQTSEEHGQE 1843

  Fly  1635 CAQLPKNNNNNLDLVNEPKPLSSQTDL-EESMSQPKSKTEFATDNQNGNRSSDELSHSSEDLLEG 1698
                            .|:..|||..| ..|.:|..|||   .|......||.:.|||
Zfish  1844 ----------------SPQDASSQKLLVSASSAQETSKT---NDRNETVSSSGQTSHS------- 1882

  Fly  1699 DGIVREELPAGKVVRRKKSNTQPPSNGN-----SINN-----NNNGTTQAPRIN----HRASVAK 1749
                          |.|.|:|  ||..:     |:.|     :|..:|.|...|    ||...:.
Zfish  1883 --------------RTKASST--PSAASKPSEPSVKNKPSAPSNTKSTAASTANPFQIHRVKSSG 1931

  Fly  1750 M------------EGLAAYLDS-SIMTSSTEVDEESKDVE--LVLPEWIVVGESVLIRPYNTSGV 1799
            :            ||...:::| |.:..|.|..|...|.|  |..|:|:..||.|.:.. |.:|.
Zfish  1932 LKSFKGILREEEEEGKTKHMESLSALNDSQETLEILSDSEESLEAPDWLKEGEYVTVGT-NKTGT 1995

  Fly  1800 IRFVGTTEFQPGAWIGVELDTPTGKNDGSVKGVQYFQCKPKHGMFVRSDKLMLDKRGKAMRAYKA 1864
            :|:||.|:|..|.|:|||||.|.|||||||.|..||.|.|.:|:.||.:           |..||
Zfish  1996 VRYVGQTDFAKGVWVGVELDVPAGKNDGSVGGRHYFHCNPGYGVLVRPN-----------RVTKA 2049

  Fly  1865 AEKSNSISKEMSTSMTGS-----MTRSKSRGDSLNLSARK 1899
            ...:..:.::...:::||     .....::|||   .|||
Zfish  2050 TGTAKRLRQKHKQNLSGSNPNLAALTVMAKGDS---GARK 2086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	249/357 (70%)
		KISc	6..359	CDD:214526	249/357 (70%)
		Kinesin_assoc	356..468	CDD:292801	69/111 (62%)
		FHA	446..546	CDD:238017	56/103 (54%)
		KIF1B	741..786	CDD:289208	23/50 (46%)
		DUF3694	<1196..1252	CDD:289256	32/57 (56%)
		CAP_GLY	1786..1850	CDD:279625	33/63 (52%)
kif13bb	XP_009299747.1	KISc_KIF1A_KIF1B	10..366	CDD:276816	249/357 (70%)
		KISc	11..366	CDD:214526	249/357 (70%)
		Kinesin_assoc	363..475	CDD:292801	69/111 (62%)
		FHA	453..550	CDD:238017	56/100 (56%)
		KIF1B	764..809	CDD:289208	23/49 (47%)
		DUF3694	<1224..1282	CDD:289256	32/57 (56%)
		CAP_GLY	1983..2046	CDD:279625	33/74 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I409
eggNOG	1	0.900	-	-		E2759_KOG0241
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1564	1.000	Inparanoid score	I87
OMA	1	1.010	-	-		QHG48008
OrthoDB	1	1.010	-	-		D15699at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26193
orthoMCL	1	0.900	-	-		OOG6_100247
Panther	1	1.100	-	-	O	PTHR24115
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2883
SonicParanoid	1	1.000	-	-		X1652
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.870