Protein Alignment Khc-73 and kif19

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_031750317.1
• Gene: kif19 / 100145702
• XenbaseID: XB-GENE-5954822
• Length: 1001
• Species: Xenopus tropicalis
• Alignment Length: 1172
• Identity: 291/1172 - (24%)
• Similarity: 483/1172 - (41%)
• Gaps: 360/1172 - (30%)

  Fly     5 KIKVAVRVRPFNRREI---------ELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCF 60
            ::.||:|:||.|..|:         ::|.:.:|.|:.    :::|..:.:..|.:.|::.||..|
 Frog    11 QLTVALRIRPINEAELGEGATIIAHKVDEQMVVLMDP----MEDPDDVLRANRSREKSYMFDVAF 71

  Fly    61 YSLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCD 125
                   :..|:|:||:....:|:::....||||.:||||.||.||:|||:||....||..|..:
 Frog    72 -------DYTATQDTVYRLTTKGLIEGVISGYNATVFAYGPTGCGKTYTMLGTDWEPGIYIRTLN 129

  Fly   126 QLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTS 190
            .||.|| .:::.::.|:|.:||||||||.:.|||:|......|:.....|:  .|.|:::::..:
 Frog   130 DLFKAI-EETSDDMEYEVLMSYMEIYNEMIRDLLNPSLGYLDLREDSKGVI--QVAGITEVSTIN 191

  Fly   191 YQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE-KVSRMSLVDLAGS 254
            .::|..|:.:|||.||...|..|..||||||:..|.:.|  ..:...::.| :|.|:.::|||||
 Frog   192 AKEIMQLLMKGNKQRTQEPTAANKTSSRSHAILQVTVRQ--KSRVKNITQEVRVGRLFMIDLAGS 254

  Fly   255 ERAVKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGG 319
            |||.:|...|.|:|||::||:||..||..|:.|:::      |.:|:|.||||.||.||||:|||
 Frog   255 ERASQTQNRGQRMKEGAHINRSLLALGNCINALSER------GGNKYVNYRDSKLTRLLKDSLGG 313

  Fly   320 NSRTVMVATISPSADNYEETLSTLRYADRAKRI---VNHAVVNEDPN----ARIIRELRHEVETL 377
            ||||||:|.|||::.::||:.:||.||||||.|   |...::|...:    ..||.:||.|::.|
 Frog   314 NSRTVMIAHISPASTSFEESRNTLTYADRAKNIKTRVKRNLLNVSYHIAQYTSIISDLRKEIQRL 378

  Fly   378 RSMLKHATGSPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGI-SVQASGIK 441
            :               :|:.|                      |..:|...||..| ::||.
 Frog   379 K---------------EKIDE----------------------QGLKQLRSEKSDIRNIQAE--- 403

  Fly   442 VEKNKYYLVNLNADP-------SLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPE---HC 496
                    |.|::.|       .|.|.|:...:::     ..|..|..:|:.|.:.:|.|   |.
 Frog   404 --------VQLHSSPYGRHEMEQLKEQLIRAFREQ-----MDIRRQLMEIENSSMEMQMETSRHF 455

  Fly   497 VITIEDSGLYMEPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQT 561
            :|..:   ...|..:.||.:        |..|:        ...:.:.:|.|.::|.
 Frog   456 LIIAD---WEQEKARRARKW--------KDELR--------KETYGKDDSEKDSDTG-------- 493

  Fly   562 PAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPST 626
                       ||  |:::. :|.:...||...|..|..|..|.:|:.|.|::|:.:|.
 Frog   494 -----------DE--QSDII-EPPEVTTARETIQILEGDQSKLRRQKLELEKRFRDIRQ------ 538

  Fly   627 PYAPYAPYDPLRMGKITPNTPTSQ---------MRVEKWAQERDEMFRRSLGQLKTDIMR-ANSL 681
                    ...|:.:..|...:|:         .:|.:...|..||...:|  ||.:::| .|.:
 Frog   539 --------RARRLEEALPKRISSEDQREILSLLCKVHELEIENTEMQSHAL--LKDNMIRQKNHM 593

  Fly   682 VQ---EANFLAEEMEKKTK---FSVTLQIPPANLSPNRRRGAFVSEPAILVKRTNSGSQIWTMEK 740
            ||   :...|.:|:.|:.:   :...|.:|
 Frog   594 VQRFEQHRSLCDEIIKQQRRIIYDHNLTVP----------------------------------- 623

  Fly   741 LENKLIDMREMY-QEHKERVLNGL------DEDNAKPQDPFYESQENHNLIGVANIFLEVLFHDV 798
              ::|.|:.|:| :|.:|.||:.:      |..::.|:.|:..::||
 Frog   624 --HQLEDLYELYFRELEEGVLDKVAVLALKDSQSSLPKIPYLTAEEN------------------ 668

  Fly   799 KLDYHTPIISQQGEVAGRLQVEIERIAGQMPQDRMCESVSESSGDSRDEYDDPVDPTSNQITCRV 863
                              ||          ..|...|||.....|:|:
 Frog   669 ------------------LQ----------EPDSDQESVRTFGSDNRN----------------- 688

  Fly   864 TIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAESTAHDQNMVFK----FEHTQDFTVT---- 920
                    |:...::           :.::|.|.:| |..|.|.|||    ..|.::..|.
 Frog   689 --------PIHRDSY-----------KNLLPRILSE-TDGDTNKVFKTSPRARHLKNGAVVTPPP 733

  Fly   921 ------INEEF--LEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIEL 977
                  |::|:  .:|.      :.:.||.::....|                |....|:||
 Frog   734 IHVNGIISKEYPPRDHL------VNISGHINSSPDST----------------DTKVALTRK--- 773

  Fly   978 WVEIHELNDNGEYSPVEVT-NRNEVLTGGIYQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVA 1041
              |..|::.:.:...|:.. .|:.||.|   ...|..:.|.|:.|..:..|...|...|...
 Frog   774 --EKREISTSIQSIAVKAARRRSRVLEG---DRLQPMKERSNLSVHSLSESEDTPFTDQRFP--- 830

  Fly  1042 IGSVTVRSRLQRPLDSYQEEDLTVL----REKWSEALGRRRQYLDQQIQMLIKKEEKNEQERERE 1102
             ||....:..:..|.|...|.:..|    ..:.|..|..|.|  .:|.|.|.|:||..|.:|.::
 Frog   831 -GSSLQHAASEDNLSSSTGEIVAALGGGGNHRDSPNLWHRAQ--KKQAQKLEKREESLEVKRRKK 892

  Fly  1103 LS 1104
            .|
 Frog   893 RS 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	143/366 (39%)
		Kinesin_assoc	356..468	CDD:465047	22/123 (18%)
		FHA_KIF13	446..547	CDD:438758	19/110 (17%)
		KIF1B	741..786	CDD:463574	13/51 (25%)
		DUF3694	989..1243	CDD:463599	31/121 (26%)
		CAP_GLY	1785..1850	CDD:460154
kif19	XP_031750317.1	KISc_KIP3_like	11..346	CDD:276821	141/356 (40%)
		SMC_N	<361..>615	CDD:481474	69/363 (19%)