DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif14l

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_002938797.1	Gene:	kif14l / 100145032	XenbaseID:	XB-GENE-5889659	Length:	1547	Species:	Xenopus tropicalis

Alignment Length:	1356	Identity:	402/1356 - (29%)
Similarity:	623/1356 - (45%)	Gaps:	309/1356 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYSLNPEDENF 70
            :.|||||||.|.||:....||::.:..|...:|:|      :..|..:|.:|.||:||.|.|.::
Frog   291 VTVAVRVRPLNERELSSGYKCVMFVLGQTIQIQHP------QTNQHLSFQYDFCFWSLEPGDSSY 349

  Fly    71 ASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESKGIIPRLCDQLFSAIANKS 135
            ||||.|::.:.:.:|...|||||.|:||||||||||||||||..|..|||||.|::||..:....
Frog   350 ASQEVVYNQIAQPLLQGVFQGYNMCLFAYGQTGSGKSYTMMGFNEEAGIIPRFCEELFQNVGCTG 414

  Fly   136 TPELMYKVEVSYMEIYNEKVHDLL-DPKP---NKQSLKVREHNVMGPYVDGLSQLAVTSYQDIDN 196
            ..|:.|.||:||.||||||:|||| .||.   ||.:||||||...||||.|||...:.|:.|:..
Frog   415 QEEVKYNVEMSYFEIYNEKIHDLLTSPKDQALNKVALKVREHPTFGPYVAGLSTYVIASFADVQT 479

  Fly   197 LMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE--KVSRMSLVDLAGSERAVK 259
            .:..|||.|..|||.||.:|||||:||.:.::|.:.:...|...:  :.||::|||||||||...
Frog   480 WLELGNKQRATAATGMNEKSSRSHSVFILSVSQTMRELLEGEVHDHTRTSRVNLVDLAGSERCNS 544

  Fly   260 TGAVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFVPYRDSVLTWLLKDNLGGNSRTV 324
            ....|.|||||::|||||.|||.|||.|::.|..||.   .|:|||||:|||||:::|||||:|.
Frog   545 AQTSGVRLKEGASINKSLLTLGKVISALSEMSEVKKR---SFIPYRDSLLTWLLRESLGGNSKTA 606

  Fly   325 MVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSMLKHATG--- 386
            |:||:||:..|.||:|||||||.:|:.|:|.|.||||..|.:||||:.|::.|::..:...|
Frog   607 MIATVSPATVNLEESLSTLRYASQARNIINVARVNEDSTAALIRELKAEIDKLKAAQQCVQGVDQ 671

  Fly   387 -------SPVGDVQDKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEK 444
                   ..:..::::|...|..:.:..::|||||...::.:.|..:.|:|.|:.     .||:.
Frog   672 ETYDASLHEIQSLRERLFIQEKELTETQKSWEEKLELAKQQKEEEAKELQKAGVC-----FKVDN 731

  Fly   445 NKYYLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHCVITIEDSGLYMEP 509
            ....|||||.||.|:|:|:|.:|....:.|:...|...:|||:|..|...||:|..:...:.:.|
Frog   732 MLPNLVNLNEDPQLSEVLLYIIKKGQTMVGKQHPGSDHEIQLTGALIAENHCLINNKAGQVSLTP 796

  Fly   510 VQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSPKSNNTSMCASEPQT----PAQLIDYNF 570
            :..|..|:||:.......|.:|||::.|.:|:||.|.|...::...:..|.|    |.   |:.|
Frog   797 LPDAETFINGNLVRNPIVLHHGDRVILGGNHYFRFNHPTEVDSVRRSVMPHTNQEGPR---DFEF 858

  Fly   571 ARDEIMQNELSNDPIQTAIARLERQHE---------EDKQVALEKQRQEYERQFQQL-------- 618
            |::|:::.:......:...|||:.|.:         |..|:.|.:|:..||.:.:||
Frog   859 AKNELIEAQTQRIENEIEDARLQAQTDMMKELQAAKEMAQMELTQQKNLYENRIRQLERELEEEL 923

  Fly   619 ------------------RNILSPSTPYAPYAPYDPLRMG----------KITPNTPTSQMRVEK 655
                              |:.|.||..|:     ..:.||          ::...|..||  |||
Frog   924 ERKRSIKRSLKESRPATGRDHLPPSGLYS-----QGVEMGIKHSKFMQVLELEKETLVSQ--VEK 981

  Fly   656 WAQERDEMFRRSLG---QLKTDIMRANSLVQEANFLAEEMEKKTKFSVTLQIPPANLSPNRRRGA 717
            ..|:.    ::|:.   |.:...::.:..:||||.:::.|.|.|.|| ...:|..:
Frog   982 MQQQG----KKSISAEKQAQWTALQLSIALQEANTISKSMNKHTVFS-RYDLPVLS--------- 1032

  Fly   718 FVSEPAILVKRTNSG---SQIWTMEKLENKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQE 779
             ..|.|:.|:.||:.   |.:|:..|.|.||:.|||:||        |..|.||  .|.||:..:
Frog  1033 -GEEQAVYVRVTNTKLGISTMWSQGKFEEKLVCMRELYQ--------GSFEGNA--DDLFYDPTD 1086

  Fly   780 NHNLIGVANIFLEVLFHDVKLDYHTP-----IISQQGEVAGRLQVEIERIAGQMPQDRMCESVSE 839
            .               .:.:....:|     .:|:|  .:|.|       .|::|.|....|.:.
Frog  1087 T---------------WEAESKQPSPKRTRNSLSRQ--TSGLL-------LGKVPTDVAVSSATF 1127

  Fly   840 SSGDSRDEYDDPVDPTSNQITCRVTI----------KCASGLPLSLSNFVFCQYTFW-------- 886
            ||                  .|:..:          |...||.|.|...:   :..|
Frog  1128 SS------------------VCKQLVISEAELLGKEKDFPGLILQLLTHL---HEVWTSTNDVLL 1171

  Fly   887 GHQEM------VVPVINAESTAHDQNMVFKFEHTQDFTVTINEEFL----EHCIEGALSIEVWGH 941
            |::::      |.|.:...|||..:             :|.:.:||    ||.:
Frog  1172 GYEQLEFGDLAVQPHLIKVSTAFSR-------------MTTSAQFLDAYPEHPV----------- 1212

  Fly   942 RSAGFSKTKGWEVEQQQAKARSLVDRWAELSRKIELWVEIH----ELNDNGEYSPVEVTNRNEVL 1002
                            ....|.|:|...:|...|...  :|    ::....:.|..::......:
Frog  1213 ----------------PCPQRQLLDELKKLGGSIAFL--LHGCECDITSMIKSSKKQINQSVTAI 1259

  Fly  1003 TGGIYQLRQGQQRRVNVRVKPVQNSGT--LPIICQSIVNVAIGSV--TVRSRLQ---RPLDSYQE 1060
            ...:.||...|  |:|....|.:..|.  ..:|.|.|....||:|  ::.|::.   :.:.|.:|
Frog  1260 AARLGQLSVSQ--RLNFSRGPEEKCGMEHTELISQKITETFIGAVEESIGSQIDFHLKEVISLEE 1322

  Fly  1061 EDLTVLRE--KWSEALGRR--------RQYLDQ------QIQMLIKKEEKNEQERE---REL--- 1103
            :...|..|  |.:|.|.:.        :.:|::      |.|.|  |.||.|..::   .||
Frog  1323 QCQKVSAESHKLAEDLRKSLLPVGNCLKNFLNKIKWFWAQYQTL--KAEKTEDAQDPAIHELYYF 1385

  Fly  1104 --SLVHQWVSLTEERNAVLVPAPGSGIPGAPASWEPPSGMEPHVPVLFLNLNGDDLSAQNTNDEL 1166
              ::.:...|||                   .:|:..|    |..:.|:...|.|.:...|  :|
Frog  1386 YSTIAYHLTSLT-------------------GAWKQLS----HKGLQFIAERGVDFTTMRT--DL 1425

  Fly  1167 SVAGINSILSKEHGHKFYTLQILQHLDKDVCCVA-SWDSSMHD----SQALNRVTE 1217
            .|...|:.|..:..:..|.....||...|:..|. .:.:::|:    ::.|.|:.|
Frog  1426 EVFSKNAPLLAKAFYSLYQDTADQHPGYDLSLVTKDFGTAVHELHSSARDLLRLVE 1481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	182/358 (51%)
		KISc	6..359	CDD:214526	182/358 (51%)
		Kinesin_assoc	356..468	CDD:292801	37/121 (31%)
		FHA	446..546	CDD:238017	35/99 (35%)
		KIF1B	741..786	CDD:289208	15/44 (34%)
		DUF3694	<1196..1252	CDD:289256	5/27 (19%)
		CAP_GLY	1786..1850	CDD:279625
kif14l	XP_002938797.1	KISc_KIF1A_KIF1B	291..641	CDD:276816	182/358 (51%)
		Kinesin_assoc	638..756	CDD:406567	38/122 (31%)
		FHA	736..833	CDD:238017	35/96 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010