Protein Alignment Khc-73 and kif1a

DIOPT Version :10

• Sequence 1: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Sequence 2: XP_031758411.1
• Gene: kif1a / 100127546
• XenbaseID: XB-GENE-960470
• Length: 1830
• Species: Xenopus tropicalis
• Alignment Length: 1528
• Identity: 485/1528 - (31%)
• Similarity: 702/1528 - (45%)
• Gaps: 434/1528 - (28%)

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.|||..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
 Frog     1 MAGASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..:|.|..|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
 Frog    62 EEDSQYAGQRQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPTQQGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.|::.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:|||||||
 Frog   127 FSRISDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYQ 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||:::.||...|.....:.||||::|||||||||||
 Frog   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDADAQTTTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG-----KKSGNDKFVPYRDSVLTWLLKDNL 317
            ..|||.|.|||||:||||||||||.|||.||:..:|     ||..|| |:|||||||||||::||
 Frog   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGTNKNKKKKKND-FIPYRDSVLTWLLRENL 319

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML- 381
            ||||||.|||.:||:..||:|||||||||||||:|..:||:|||||.|:||||:.||..||.:|
 Frog   320 GGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLIRELKDEVARLRDLLG 384

  Fly   382 ----------------------KHA-----------TG-SPVGDVQ------------------- 393
                                  :||           || ||...:.
 Frog   385 AQGLSDIIDNVCPVDNGNVLHKRHAADNLFTAVNALTGMSPSSSMSGLSSRAASVTSLHERLAFT 449

  Fly   394 -------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS----GIKVEKNKY 447
                   ::|.|:|.::.::::||||||.:||.|:.:|:..|.:||::::..    |:...|...
 Frog   450 PGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMDREALLAEMGVAMREDGGTLGVFSPKKTP 514

  Fly   448 YLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHC-----VITIEDSGLYM 507
            :|||||.||.::|.|:||:||.....||..:..:.||.|||..|:.|||     |:......:.:
 Frog   515 HLVNLNEDPLMSECLLYYIKDGITRVGREDATMRQDIVLSGHFIRDEHCIFRSDVLACGSVVVTL 579

  Fly   508 EPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSMCASEPQTPAQLIDY 568
            ||..||..:|||....:...|::|:||:.|..|.||.|.|    :....:.||   :||::.:|:
 Frog   580 EPCDGADTYVNGKKLTDPCILRSGNRIIMGKSHVFRFNHPEQARQERERTPCA---ETPSEPVDW 641

  Fly   569 NFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYERQFQQLRNILSPSTP 627
            .||:.|:::.: ..|..|....||:      |:..|:....||:||.:||.:.:.|:..:.
 Frog   642 AFAQRELLEKQ-GIDMKQEMDQRLQELEDQYRKEREEANYLLEQQRLDYESRLEALQRQMD---- 701

  Fly   628 YAPY---------APYDPLRMGKITPNTPTSQMRVEKWAQ---ERDEMFRRSLGQLKTDIMRANS 680
             :.|         .|.|.::..:...:......|..||.|   .||:::..::
 Frog   702 -SRYFTEVNEEEEEPEDEVQWTEQEYDLALWAFRKWKWYQFTSLRDQLWGNAI------------ 753

  Fly   681 LVQEANFLAEEMEKKTKFSVTL-------QIPPANLSPN----RRRGAFVSEPAILV-----KRT 729
            .::|||.::.|::||.:|...|       .:||..|.|:    |.:..|   |..:|     .:.
 Frog   754 FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPDAHTEREKRPF---PRTIVAVEVQDQK 815

  Fly   730 NSGSQIWTMEKLENKLIDMREMYQ----------EHKERVLNGLD-------------------- 764
            |..:..||:|||..:|..|||||.          |..:.|:.|.|
 Frog   816 NGATHYWTLEKLRQRLDMMREMYDRAAELPSGLTEDCDNVVTGGDPFYDRFPWFRLVGSSPLFTT 880

  Fly   765 ---------------------------------------EDNAKPQ---------DPFYESQENH 781
                                                   |::..||         |||::.....
 Frog   881 CMSESMAEITPSPTLSSPGSEGPEPASQLEEEDIFQDDEEEDDGPQEHPCCAVRSDPFHDRSPLF 945

  Fly   782 NLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG-------------------- 826
            :::|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.|:.
 Frog   946 SVVGRAFVYLSNLLYSVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKIS 1010

  Fly   827 ------QMPQDRMCESVSESSGDSRDE----------------------------------YDDP 851
                  |..|...|..::. ||.|::|                                  .|.|
 Frog  1011 FDDQHFQKFQAETCPGMTR-SGTSQEELRIVEGGQGQNPDSCPSADEVNNNTCAASLQSSLLDSP 1074

  Fly   852 VDP-------------TSNQITCRVTIKCASGLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTA 902
            ..|             ..:..|.|||:..||.:|...:: :|||:.| ..|.|       |.||.
 Frog  1075 TKPPFDLSDTMGHPLKLGSIFTFRVTVLQASSIPPEYAD-IFCQFNFIHRHDE-------AFSTE 1131

  Fly   903 HDQNM----VFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARS 963
            ..:|.    ...|.|.|:..|.:.:.|:|:.....:..||:||...........:|......:|.
 Frog  1132 PLKNTGRGPPLGFYHVQNIAVEVTQSFVEYVKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRSSRR 1196

  Fly   964 LVDRWAELSR--------------------KIEL--WVEIHELNDNGEYSPVEVTNRNEVLTGGI 1006
            |:.|...||:                    |.:|  :.:|.||..||:|.||.|.:...:...|.
 Frog  1197 LLPRVMPLSKPVPATKLSRQRVPSVGPCHCKYDLMAYFQICELEANGDYIPVSVDHGVGLPCHGT 1261

  Fly  1007 YQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWS 1071
            :.|.||.|||::|.:  |..:|.                                     ..||.
 Frog  1262 FLLHQGIQRRISVTL--VHEAGA-------------------------------------ELKWL 1287

  Fly  1072 EALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWE 1136
            |            ::.|:....:|..|.:..|.          :.|.:.:....:|       :.
 Frog  1288 E------------VRELVVGRIRNTPEADESLI----------DPNILSLNILSAG-------YR 1323

  Fly  1137 PPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVAS 1201
            ||.|.:...      |:.|..|.|               |......||..::            :
 Frog  1324 PPEGGDRQF------LDSDTPSCQ---------------SGRGTRTFYHFEV------------A 1355

  Fly  1202 WDSSMHDSQALNRVTEANERVYLILRTTVRLSH 1234
            ||||||:|..|||||...|::|:.|...|.:.:
 Frog  1356 WDSSMHNSLLLNRVTPYREKIYMTLSAYVEMEN 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/362 (61%)
		Kinesin_assoc	356..468	CDD:465047	52/176 (30%)
		FHA_KIF13	446..547	CDD:438758	41/105 (39%)
		KIF1B	741..786	CDD:463574	17/122 (14%)
		DUF3694	989..1243	CDD:463599	49/246 (20%)
		CAP_GLY	1785..1850	CDD:460154
kif1a	XP_031758411.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	220/362 (61%)
		Kinesin_assoc	358..537	CDD:465047	54/178 (30%)
		FHA_KIF1A	513..627	CDD:438778	42/113 (37%)
		KIF1B	827..874	CDD:463574	11/46 (24%)
		DUF3694	1244..1408	CDD:463599	49/246 (20%)
		PH_KIFIA_KIFIB	1711..1813	CDD:269939