DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Khc-73 and kif1a

DIOPT Version :9

Sequence 1:	NP_001261000.1	Gene:	Khc-73 / 36718	FlyBaseID:	FBgn0019968	Length:	1957	Species:	Drosophila melanogaster
Sequence 2:	XP_031758411.1	Gene:	kif1a / 100127546	XenbaseID:	XB-GENE-960470	Length:	1830	Species:	Xenopus tropicalis

Alignment Length:	1528	Identity:	485/1528 - (31%)
Similarity:	702/1528 - (45%)	Gaps:	434/1528 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIERKQPKTFAFDHCFYS-LN 64
            ||...:||||||||||.|||..|:|||::|....|.:.||    |..::.||:|:||:.::| .:
Frog     1 MAGASVKVAVRVRPFNSREIGKDSKCIIQMSGNTTTIVNP----KQPKETPKSFSFDYSYWSHTS 61

  Fly    65 PEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQE--SKGIIPRLCDQL 127
            .||..:|.|..|:..:|..:|.:||:|||.|||||||||:||||||||.||  .:||||:||:.|
Frog    62 EEDSQYAGQRQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPTQQGIIPQLCEDL 126

  Fly   128 FSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVREHNVMGPYVDGLSQLAVTSYQ 192
            ||.|::.:...:.|.|||||||||.|:|.|||:|| ||.:|:||||.::||||:.||:|||||||
Frog   127 FSRISDTTNDNMSYSVEVSYMEIYCERVRDLLNPK-NKGNLRVREHPLLGPYVEDLSKLAVTSYQ 190

  Fly   193 DIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGEKVSRMSLVDLAGSERA 257
            ||.:||..|||:|||||||||..||||||||:::.||...|.....:.||||::|||||||||||
Frog   191 DIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQRRHDADAQTTTEKVSKISLVDLAGSERA 255

  Fly   258 VKTGAVGDRLKEGSNINKSLTTLGLVISKLADQSNG-----KKSGNDKFVPYRDSVLTWLLKDNL 317
            ..|||.|.|||||:||||||||||.|||.||:..:|     ||..|| |:|||||||||||::||
Frog   256 DSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGTNKNKKKKKND-FIPYRDSVLTWLLRENL 319

  Fly   318 GGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNARIIRELRHEVETLRSML- 381
            ||||||.|||.:||:..||:|||||||||||||:|..:||:|||||.|:||||:.||..||.:|
Frog   320 GGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLIRELKDEVARLRDLLG 384

  Fly   382 ----------------------KHA-----------TG-SPVGDVQ------------------- 393
                                  :||           || ||...:.
Frog   385 AQGLSDIIDNVCPVDNGNVLHKRHAADNLFTAVNALTGMSPSSSMSGLSSRAASVTSLHERLAFT 449

  Fly   394 -------DKLAESENLMKQISQTWEEKLVKTERIQNERQQALEKMGISVQAS----GIKVEKNKY 447
                   ::|.|:|.::.::::||||||.:||.|:.:|:..|.:||::::..    |:...|...
Frog   450 PGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMDREALLAEMGVAMREDGGTLGVFSPKKTP 514

  Fly   448 YLVNLNADPSLNELLVYYLKDRTLIGGRTISGQQPDIQLSGLGIQPEHC-----VITIEDSGLYM 507
            :|||||.||.::|.|:||:||.....||..:..:.||.|||..|:.|||     |:......:.:
Frog   515 HLVNLNEDPLMSECLLYYIKDGITRVGREDATMRQDIVLSGHFIRDEHCIFRSDVLACGSVVVTL 579

  Fly   508 EPVQGARCFVNGSAAVEKTPLQNGDRILWGNHHFFRVNSP----KSNNTSMCASEPQTPAQLIDY 568
            ||..||..:|||....:...|::|:||:.|..|.||.|.|    :....:.||   :||::.:|:
Frog   580 EPCDGADTYVNGKKLTDPCILRSGNRIIMGKSHVFRFNHPEQARQERERTPCA---ETPSEPVDW 641

  Fly   569 NFARDEIMQNELSNDPIQTAIARLE------RQHEEDKQVALEKQRQEYERQFQQLRNILSPSTP 627
            .||:.|:::.: ..|..|....||:      |:..|:....||:||.:||.:.:.|:..:.
Frog   642 AFAQRELLEKQ-GIDMKQEMDQRLQELEDQYRKEREEANYLLEQQRLDYESRLEALQRQMD---- 701

  Fly   628 YAPY---------APYDPLRMGKITPNTPTSQMRVEKWAQ---ERDEMFRRSLGQLKTDIMRANS 680
             :.|         .|.|.::..:...:......|..||.|   .||:::..::
Frog   702 -SRYFTEVNEEEEEPEDEVQWTEQEYDLALWAFRKWKWYQFTSLRDQLWGNAI------------ 753

  Fly   681 LVQEANFLAEEMEKKTKFSVTL-------QIPPANLSPN----RRRGAFVSEPAILV-----KRT 729
            .::|||.::.|::||.:|...|       .:||..|.|:    |.:..|   |..:|     .:.
Frog   754 FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPDAHTEREKRPF---PRTIVAVEVQDQK 815

  Fly   730 NSGSQIWTMEKLENKLIDMREMYQ----------EHKERVLNGLD-------------------- 764
            |..:..||:|||..:|..|||||.          |..:.|:.|.|
Frog   816 NGATHYWTLEKLRQRLDMMREMYDRAAELPSGLTEDCDNVVTGGDPFYDRFPWFRLVGSSPLFTT 880

  Fly   765 ---------------------------------------EDNAKPQ---------DPFYESQENH 781
                                                   |::..||         |||::.....
Frog   881 CMSESMAEITPSPTLSSPGSEGPEPASQLEEEDIFQDDEEEDDGPQEHPCCAVRSDPFHDRSPLF 945

  Fly   782 NLIGVANIFLEVLFHDVKLDYHTPIISQQGEVAGRLQVEIERIAG-------------------- 826
            :::|.|.::|..|.:.|.|.:...|:|::|||.|.|:|.::.|:.
Frog   946 SVVGRAFVYLSNLLYSVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGSGVRQSGTAKIS 1010

  Fly   827 ------QMPQDRMCESVSESSGDSRDE----------------------------------YDDP 851
                  |..|...|..::. ||.|::|                                  .|.|
Frog  1011 FDDQHFQKFQAETCPGMTR-SGTSQEELRIVEGGQGQNPDSCPSADEVNNNTCAASLQSSLLDSP 1074

  Fly   852 VDP-------------TSNQITCRVTIKCASGLPLSLSNFVFCQYTF-WGHQEMVVPVINAESTA 902
            ..|             ..:..|.|||:..||.:|...:: :|||:.| ..|.|       |.||.
Frog  1075 TKPPFDLSDTMGHPLKLGSIFTFRVTVLQASSIPPEYAD-IFCQFNFIHRHDE-------AFSTE 1131

  Fly   903 HDQNM----VFKFEHTQDFTVTINEEFLEHCIEGALSIEVWGHRSAGFSKTKGWEVEQQQAKARS 963
            ..:|.    ...|.|.|:..|.:.:.|:|:.....:..||:||...........:|......:|.
Frog  1132 PLKNTGRGPPLGFYHVQNIAVEVTQSFVEYVKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRSSRR 1196

  Fly   964 LVDRWAELSR--------------------KIEL--WVEIHELNDNGEYSPVEVTNRNEVLTGGI 1006
            |:.|...||:                    |.:|  :.:|.||..||:|.||.|.:...:...|.
Frog  1197 LLPRVMPLSKPVPATKLSRQRVPSVGPCHCKYDLMAYFQICELEANGDYIPVSVDHGVGLPCHGT 1261

  Fly  1007 YQLRQGQQRRVNVRVKPVQNSGTLPIICQSIVNVAIGSVTVRSRLQRPLDSYQEEDLTVLREKWS 1071
            :.|.||.|||::|.:  |..:|.                                     ..||.
Frog  1262 FLLHQGIQRRISVTL--VHEAGA-------------------------------------ELKWL 1287

  Fly  1072 EALGRRRQYLDQQIQMLIKKEEKNEQERERELSLVHQWVSLTEERNAVLVPAPGSGIPGAPASWE 1136
            |            ::.|:....:|..|.:..|.          :.|.:.:....:|       :.
Frog  1288 E------------VRELVVGRIRNTPEADESLI----------DPNILSLNILSAG-------YR 1323

  Fly  1137 PPSGMEPHVPVLFLNLNGDDLSAQNTNDELSVAGINSILSKEHGHKFYTLQILQHLDKDVCCVAS 1201
            ||.|.:...      |:.|..|.|               |......||..::            :
Frog  1324 PPEGGDRQF------LDSDTPSCQ---------------SGRGTRTFYHFEV------------A 1355

  Fly  1202 WDSSMHDSQALNRVTEANERVYLILRTTVRLSH 1234
            ||||||:|..|||||...|::|:.|...|.:.:
Frog  1356 WDSSMHNSLLLNRVTPYREKIYMTLSAYVEMEN 1388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	220/362 (61%)
		KISc	6..359	CDD:214526	220/360 (61%)
		Kinesin_assoc	356..468	CDD:292801	52/176 (30%)
		FHA	446..546	CDD:238017	40/104 (38%)
		KIF1B	741..786	CDD:289208	17/122 (14%)
		DUF3694	<1196..1252	CDD:289256	16/39 (41%)
		CAP_GLY	1786..1850	CDD:279625
kif1a	XP_031758411.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D76316at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010