DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and GALNT12

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_078918.3	Gene:	GALNT12 / 79695	HGNCID:	19877	Length:	581	Species:	Homo sapiens

Alignment Length:	617	Identity:	222/617 - (35%)
Similarity:	318/617 - (51%)	Gaps:	95/617 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIIFILVALC---FILYSK------VQQNGSPEEP------PVAPL--VRAAALRGHGRERFEAY 59
            |::..|:||.   .:|.::      ..:.|.|..|      ||.|.  |.|.||...|
Human    22 LVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARG------- 79

  Fly    60 SDSENEIARPATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQL 124
                             :.::|.||.:::.|.|:.|.:|                .:|..||:::
Human    80 -----------------EAVRLQLQGEELRLQEESVRLH----------------QINIYLSDRI 111

  Fly   125 TYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDD 189
            :.:|.:.:..||||.::::|.|:||..||:|.|:||.:|.|||||:|.|.|..:..|:|:|||||
Human   112 SLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDD 176

  Fly   190 GSDNVELGAKLDYYVRTRIPSG--KVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIG 252
            .||...|..:|...:     ||  ||.::|...|.||:||||.||..|.||||.|||.|||.:.|
Human   177 YSDREHLKERLANEL-----SGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEG 236

  Fly   253 WCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRR 317
            |.|||||||.|..::|:.|:|||||.|.|:|..|..:. |:|||.|...|.|..:||||:.|.:.
Human   237 WLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEP-QIGGFDWRLVFTWHTVPERERIRMQS 300

  Fly   318 ECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCS 382
            .....|      ||||||||||:.::||..:||||..|:.|||||||.|||||||||.:||.|||
Human   301 PVDVIR------SPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCS 359

  Fly   383 RVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKK 447
            .|||:|    |.:.|..|:....|:.|.|.|||||:..:::...|..:.. ..||||.|..||.|
Human   360 HVGHVF----PKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLE-PFGDVTERKQLRDK 419

  Fly   448 LRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVN-SNICLD----DLLQNNEKPYNAGLYPCGKV 507
            |:||.|:|:|:.:|||..||......:|.:.... ::.|.|    |  :|....:...||.|..:
Human   420 LQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPD--ENQIVGHQVILYLCHGM 482

  Fly   508 LQKSQLFSFTNTNVLRNEL----SCATVQHSESPPYRVVMVPCMENDEFNEQW-RYEHQHIIHSN 567
            .| :|.|.:|:...:|...    .|..|   |:....::|..|.|....|::: ..|...:.|..
Human   483 GQ-NQFFEYTSQKEIRYNTHQPEGCIAV---EAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQ 543

  Fly   568 TGMCLDHQGLKSLDD--AQVAPCDPHSESQRW 597
            :..|:.....:|.|.  ..:..| .:|:.|:|
Human   544 SKKCVQAARKESSDSFVPLLRDC-TNSDHQKW 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	140/280 (50%)
		pp-GalNAc-T	152..461	CDD:133004	153/310 (49%)
		Ricin_B_lectin	474..597	CDD:279046	28/134 (21%)
		RICIN	481..599	CDD:238092	28/129 (22%)
GALNT12	NP_078918.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..67		5/23 (22%)
		WcaA	134..429	CDD:223539	154/311 (50%)
		Catalytic subdomain A	135..244		59/113 (52%)
		pp-GalNAc-T	139..433	CDD:133004	153/310 (49%)
		Catalytic subdomain B	304..366		43/71 (61%)
		Ricin_B_lectin	445..574	CDD:279046	28/135 (21%)
		RICIN	447..576	CDD:238092	29/135 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.721928	Normalized mean entropy	S3838
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.770