Protein Alignment Pgant1 and GALNT17

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_071924.1
• Gene: GALNT17 / 64409
• HGNCID: 16347
• Length: 598
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 214/632 - (33%)
• Similarity: 328/632 - (51%)
• Gaps: 88/632 - (13%)

  Fly    12 LIIFILVALC-FILY-SKVQQNGSPEEPPVAPLVRAAALRGHGRERFE-----AYSDSENEIARP 69
            |::..|:|:. |:|: :|.:        |:|  ||:.......|.|.|     |:|.|..:.|..
Human    10 LLVLNLIAVAGFVLFLAKCR--------PIA--VRSGDAFHEIRPRAEVANLSAHSASPIQDAVL 64

  Fly    70 ATQSPYEQII--QLDLQKQKVGL-------GEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLT 125
            ...|..|.|:  ||:...:.:||       |:.|:...||.|.:|:....::|...|..|||:::
Human    65 KRLSLLEDIVYRQLNGLSKSLGLIEGYGGRGKGGLPATLSPAEEEKAKGPHEKYGYNSYLSEKIS 129

  Fly   126 YNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDG 190
            .:||:.|:|...|.:.::..| ||..|::.||.||..||:||:|||.::......|||||||||.
Human   130 LDRSIPDYRPTKCKELKYSKD-LPQISIIFIFVNEALSVILRSVHSAVNHTPTHLLKEIILVDDN 193

  Fly   191 SDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCE 255
            ||..||...|:.||..|.| |.|.::|.:.|.||||||:.|.::|||.|..|.|||.|...||.|
Human   194 SDEEELKVPLEEYVHKRYP-GLVKVVRNQKREGLIRARIEGWKVATGQVTGFFDAHVEFTAGWAE 257

  Fly   256 PLLQRIKESRTSVLVPIIDVIDANDFQY-----STNGYKSFQVGGFQWNGHFDWINLPEREKQRQ 315
            |:|.||:|:|..|::|.||.|..::|:.     |.:|| |:::.....:...||.:..:..
Human   258 PVLSRIQENRKRVILPSIDNIKQDNFEVQRYENSAHGY-SWELWCMYISPPKDWWDAGDPS---- 317

  Fly   316 RRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIP 380
                      .|..:|.|.|..|.::|::|.|:|..|..||.:||||:|:..::|.|||::|.:|
Human   318 ----------LPIRTPAMIGCSFVVNRKFFGEIGLLDPGMDVYGGENIELGIKVWLCGGSMEVLP 372

  Fly   381 CSRVGHIFRDFHPYK----FPNDRDTHGINTARMALVWMDEYINIFFL--NRPDLKFHADIGDVT 439
            ||||.||.|...||.    |...|     |..|:|.||||:|.:..::  |.|......|||||:
Human   373 CSRVAHIERKKKPYNSNIGFYTKR-----NALRVAEVWMDDYKSHVYIAWNLPLENPGIDIGDVS 432

  Fly   440 HRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNS-NICLDDLLQNNEKPYNAGLYP 503
            .|..|||.|:||:|:|||.::|||.......| .:|::....: ::|||   |...:.:.|.|||
Human   433 ERRALRKSLKCKNFQWYLDHVYPEMRRYNNTV-AYGELRNNKAKDVCLD---QGPLENHTAILYP 493

  Fly   504 C---GKVLQKSQLFSFTN-----TNVLRNELSCATVQHSES--PPYRVVMVPCME-NDEFNEQWR 557
            |   |..|.:.....|.:     |..|..:..| .|.:|:|  |.    ::.|.: .....::|.
Human   494 CHGWGPQLARYTKEGFLHLGALGTTTLLPDTRC-LVDNSKSRLPQ----LLDCDKVKSSLYKRWN 553

  Fly   558 Y-EHQHIIHSNTGMCL--DHQGLKSLDDAQVAPCDPHSESQRWTIEH 601
            : ::..|::..||.||  :::||..: |..:..|    ..|||||::
Human   554 FIQNGAIMNKGTGRCLEVENRGLAGI-DLILRSC----TGQRWTIKN 595

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	131/319 (41%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	37/147 (25%)
GALNT17	NP_071924.1	Catalytic subdomain A	151..262		57/111 (51%)
		pp-GalNAc-T	155..454	CDD:133004	131/319 (41%)
		Catalytic subdomain B	319..381		29/61 (48%)
		beta-trefoil_Ricin_GALNT17	457..598	CDD:467352	37/153 (24%)