DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and GALNT11

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001358393.1	Gene:	GALNT11 / 63917	HGNCID:	19875	Length:	667	Species:	Homo sapiens

Alignment Length:	618	Identity:	232/618 - (37%)
Similarity:	330/618 - (53%)	Gaps:	93/618 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FRSFYGKLIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRGHG------RERFEAYSDSE 63
            |.|....:::|:     :..:|:|.|          || :...::|.|      ::.:..::...
Human    15 FTSATWTVLLFV-----YFNFSEVTQ----------PL-KNVPVKGSGPHGPSPKKFYPRFTRGP 63

  Fly    64 NEIARPATQ-SPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAK------ERGDEI----YKKIALN 117
            :.:..|..: :..:.:|...::..:.|        ||..:::      ||..|:    |:|.|.|
Human    64 SRVLEPQFKANKIDDVIDSRVEDPEEG--------HLKFSSELGMIFNERDQELRDLGYQKHAFN 120

  Fly   118 EELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALK 182
            ..:|::|.|:|.|.|.||..| |::|....||.|||||.|:||.:|.|||||||.:.......|.
Human   121 MLISDRLGYHRDVPDTRNAAC-KEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLH 184

  Fly   183 EIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHC 247
            |||||||.||..:|..:||.||:..:| ||:.::|...|.||||.|:.||..|||:||:|||:||
Human   185 EIILVDDDSDFDDLKGELDEYVQKYLP-GKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHC 248

  Fly   248 EGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREK 312
            |.|:.|.:|||..|:|.|.:|:.|:||:|.|:...||::....   |||.|..||.|..:|..|.
Human   249 EVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVR---GGFNWGLHFKWDLVPLSEL 310

  Fly   313 QRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIE 377
            .|      .|....|..||||||||||::|:||.|:|.||..||.|||||||:|||||.|||.:.
Human   311 GR------AEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLF 369

  Fly   378 TIPCSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRV 442
            .|||||||||||...||..|..:||...|:.|:|.||:|||...:|..|||||..: .|:::.||
Human   370 IIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKS-YGNISERV 433

  Fly   443 MLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHA-------VNSNICLDDLLQNNEKPYNAG 500
            .|||||.||||:|||.|:|||     ..:.|   .||       ||         :..::|
Human   434 ELRKKLGCKSFKWYLDNVYPE-----MQISG---SHAKPQQPIFVN---------RGPKRP---- 477

  Fly   501 LYPCGKVLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHIIH 565
                 ||||:.:|:.. .||      .|...|...|....:|::...:..:.|:.|.|..:|.:.
Human   478 -----KVLQRGRLYHL-QTN------KCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELV 530

  Fly   566 SNTGMCLDHQGLKSLDDAQVAPCDPHSESQRWT 598
            .|:.:|||....:|.|..::..|.....||:||
Human   531 LNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWT 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	143/278 (51%)
		pp-GalNAc-T	152..461	CDD:133004	161/308 (52%)
		Ricin_B_lectin	474..597	CDD:279046	29/129 (22%)
		RICIN	481..599	CDD:238092	28/118 (24%)
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		61/111 (55%)
		pp-GalNAc-T	154..452	CDD:133004	161/308 (52%)
		Catalytic subdomain B	319..381		44/61 (72%)
		Ricin_B_lectin	483..>564	CDD:366226	22/88 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820