Protein Alignment Pgant1 and GALNT11

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001358393.1
• Gene: GALNT11 / 63917
• HGNCID: 19875
• Length: 667
• Species: Homo sapiens
• Alignment Length: 615
• Identity: 230/615 - (37%)
• Similarity: 327/615 - (53%)
• Gaps: 87/615 - (14%)

  Fly     5 FRSFYGKLIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRGHG------RERFEAYSDSE 63
            |.|....:::|:     :..:|:|.|          || :...::|.|      ::.:..::...
Human    15 FTSATWTVLLFV-----YFNFSEVTQ----------PL-KNVPVKGSGPHGPSPKKFYPRFTRGP 63

  Fly    64 NEIARPATQ-SPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAK------ERGDEI----YKKIALN 117
            :.:..|..: :..:.:|...::..:.|        ||..:::      ||..|:    |:|.|.|
Human    64 SRVLEPQFKANKIDDVIDSRVEDPEEG--------HLKFSSELGMIFNERDQELRDLGYQKHAFN 120

  Fly   118 EELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALK 182
            ..:|::|.|:|.|.|.||..| |::|....||.|||||.|:||.:|.|||||||.:.......|.
Human   121 MLISDRLGYHRDVPDTRNAAC-KEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLH 184

  Fly   183 EIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHC 247
            |||||||.||..:|..:||.||:..:| ||:.::|...|.||||.|:.||..|||:||:|||:||
Human   185 EIILVDDDSDFDDLKGELDEYVQKYLP-GKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHC 248

  Fly   248 EGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREK 312
            |.|:.|.:|||..|:|.|.:|:.|:||:|.|:...||::....   |||.|..||.|..:|..|.
Human   249 EVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVR---GGFNWGLHFKWDLVPLSEL 310

  Fly   313 QRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIE 377
            .|      .|....|..||||||||||::|:||.|:|.||..||.|||||||:|||||.|||.:.
Human   311 GR------AEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLF 369

  Fly   378 TIPCSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRV 442
            .|||||||||||...||..|..:||...|:.|:|.||:|||...:|..|||||..: .|:::.||
Human   370 IIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKS-YGNISERV 433

  Fly   443 MLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCG-- 505
            .|||||.||||:|||.|:|||     ..:.|                  ::.||........|
Human   434 ELRKKLGCKSFKWYLDNVYPE-----MQISG------------------SHAKPQQPIFVNRGPK 475

  Fly   506 --KVLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHIIHSNT 568
              ||||:.:|:.. .||      .|...|...|....:|::...:..:.|:.|.|..:|.:..|:
Human   476 RPKVLQRGRLYHL-QTN------KCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNS 533

  Fly   569 GMCLDHQGLKSLDDAQVAPCDPHSESQRWT 598
            .:|||....:|.|..::..|.....||:||
Human   534 LLCLDMSETRSSDPPRLMKCHGSGGSQQWT 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	161/308 (52%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	30/135 (22%)
GALNT11	NP_001358393.1	Catalytic subdomain A	150..261		61/111 (55%)
		pp-GalNAc-T	154..452	CDD:133004	161/308 (52%)
		Catalytic subdomain B	319..381		44/61 (72%)
		beta-trefoil_Ricin_GALNT11	478..>565	CDD:467318	26/93 (28%)