DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and galntl6

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001139074.1	Gene:	galntl6 / 568915	ZFINID:	ZDB-GENE-090312-115	Length:	600	Species:	Danio rerio

Alignment Length:	547	Identity:	197/547 - (36%)
Similarity:	287/547 - (52%)	Gaps:	54/547 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 YEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVGDHRNPLCA 139
            ||.|.:   ..|:||.||.|....|  ...|..|.:||:...|..:|..:..:||:.|.|:|.|
Zfish    71 YESIRK---DGQRVGKGEHGKPYPL--VEDECDDSVYKENGFNIYVSNNIALDRSLPDIRHPNC- 129

  Fly   140 KQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYV 204
            ||:...::||..|::|.|.||.:|.||||:||..:...:..:.|||||||.||...|.|.|..|:
Zfish   130 KQKLYLENLPNTSIIIPFHNEGWSSLLRTLHSISNRTPDHLIAEIILVDDYSDREHLKAHLAEYM 194

  Fly   205 RTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVL 269
             :|.|  ||.|:|.|.|.||||.||.||.:|.|:||.|||:|||.||.|..|||.:|.::..:::
Zfish   195 -SRFP--KVRIVRTKKREGLIRTRLLGASVARGEVLTFLDSHCEANINWLPPLLDQIAQNPKTIV 256

  Fly   270 VPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMA 334
            .|:|||||.|.|.|......:.: |.|.|..::..|.:|.        |.:......|..||.||
Zfish   257 CPMIDVIDHNHFGYEAQAGDAMR-GAFDWEMYYKRIPIPP--------ELQGPDPSDPYQSPVMA 312

  Fly   335 GGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPND 399
            |||||::|::|||:|.||..::.||||..|:||::|.|||::..:||||||||:|.:.|||.|:.
Zfish   313 GGLFAVNRQWFWELGGYDTGLEIWGGEQFEISFKVWMCGGSMYDVPCSRVGHIYRKYVPYKVPSG 377

  Fly   400 RDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNI---Y 461
            ... ..|..|:|..|||||....:..||:.: |...||:|.:..|||.|:||.|:||:..:   .
Zfish   378 TSL-ARNLKRVAETWMDEYTEYIYQRRPEYR-HLSTGDLTAQKELRKHLKCKDFKWYMNTVAWDL 440

  Fly   462 PEKFVPTKDV-QGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGK-----VLQKSQLFSF---- 516
            |:.:.|.:.: ..||::....|.:|:|.  ::........|..|.|     .....|:|:|
Zfish   441 PKYYPPVEPLPAAWGEIRNAASGLCVDS--KHGSTGTELRLDNCLKEGAERTWAHEQIFTFGWRE 503

  Fly   517 --TNTNVLRNELSCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQ----HIIHSNTGMCLDHQ 575
              ...:.|.....|.......||   :.:..| ...:.|:.|.|...    |::.|.   |:|
Zfish   504 DIRPGDPLHTRKFCFDAISQNSP---ITLYDC-HGMKGNQHWSYRKDKSLYHLVSSG---CMD-- 559

  Fly   576 GLKSLDDAQV--APCDPHSESQRWTIE 600
              .|.:|.::  ..|||.||:|:|..:
Zfish   560 --CSPNDKRIFMNKCDPKSETQQWIFQ 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	124/278 (45%)
		pp-GalNAc-T	152..461	CDD:133004	137/311 (44%)
		Ricin_B_lectin	474..597	CDD:279046	31/139 (22%)
		RICIN	481..599	CDD:238092	30/134 (22%)
galntl6	NP_001139074.1	pp-GalNAc-T	142..437	CDD:133004	137/308 (44%)
		Glyco_tranf_2_2	142..404	CDD:287123	122/274 (45%)
		Ricin_B_lectin	453..581	CDD:279046	31/140 (22%)
		RICIN	455..583	CDD:238092	31/140 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810