DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and galnt8b.1

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	XP_021331085.1	Gene:	galnt8b.1 / 559373	ZFINID:	ZDB-GENE-041210-83	Length:	629	Species:	Danio rerio

Alignment Length:	661	Identity:	196/661 - (29%)
Similarity:	322/661 - (48%)	Gaps:	106/661 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SFYGKLIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRG----HGRERFEAY--SDSENE 65
            ||...|...:.||:.|:..|.|:.....:|..:..:.:..:|..    |..::.||:  :..|:.
Zfish     4 SFVKSLFPVLSVAVVFLYLSSVKWEIKTQEEKLQRVQQNLSLHSSLLLHKLDKLEAHLIAVEESR 68

  Fly    66 IARPATQSPYEQII-QLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRS 129
            :...:.:.|.:::. ..||.|:        .:|.||...:.:.:::::|...|..||::|..:|.
Zfish    69 LKVKSEKKPAKKLFPDSDLFKR--------WSVELSEDEQRKAEDLFQKYGYNAFLSDRLPLDRE 125

  Fly   130 VGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNV 194
            :.|.|:..||::.:..| |||.|||:|:.:|..||:.|.|:|.::......|||||||||.|.|.
Zfish   126 LPDTRDHRCAEREYPPD-LPTVSVVLIYLDEALSVIQRAVYSIINRTPAHLLKEIILVDDHSTNE 189

  Fly   195 ELGAKLDYYVRT---RIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEP 256
            :|..:|..|:.:   :.| |.|.::....:.||.:||::|.:.|:|||:..||||.|.::.|.||
Zfish   190 DLQTQLHVYISSINEKHP-GLVKMVTHAEQKGLSQARISGWKAASGDVVAILDAHIEVHVKWAEP 253

  Fly   257 LLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSF-QVGGFQWNGHFDWINLPEREKQRQRRECK 320
            ||.||:..||.||.|:.|.|:.:|.:.:    |.| ...||.|.....::..|::...|....
Zfish   254 LLARIQADRTLVLSPVFDKINYDDLEVT----KYFASAHGFDWALWCMYVTFPKKWYNRNDPS-- 312

  Fly   321 QEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFR----------------- 368
                 .|..||::. |:..:||.:|.|:|:.||.|..:||||:|:..|
Zfish   313 -----LPGKSPSVM-GILVVDRLFFGEIGTLDEGMQVYGGENVELGIRVIHHHTEAFIILLYLHV 371

  Fly   369 -----------------IWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMD 416
                             :|.|||:||.:|||::.||.|...|| .|:..:....|..|:|.||||
Zfish   372 EQWCCCSLLTLGCVLAQVWLCGGSIEVVPCSKIAHIERAHKPY-MPDLSNVMKRNALRVAEVWMD 435

  Fly   417 EY-INIFFLNRPDLKFHA-DIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGK-VH 478
            || .|::......|:.|. ||||::.|..||::|.||.|:|||:|:|.| ..|..|:.|:|. ::
Zfish   436 EYKKNVYMAWGLPLENHGIDIGDLSERKKLRERLNCKPFKWYLENVYTE-LNPMDDLLGYGALIN 499

  Fly   479 AVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNELSCATVQ---HSESPPYR 540
            .:.:::|||........|.   ||||.  ...||:|.:|.:    .|:....:|   ||.:   |
Zfish   500 DLQTSLCLDKGPSEENTPI---LYPCH--FLTSQVFFYTTS----GEILVGPLQPLLHSRN---R 552

  Fly   541 VVMVP----------CMENDEFNEQ-WRYEH-QHIIHSNTGMCLDHQGLKSLD---DAQVAPCDP 590
            .:..|          |.:.::.... |.::. |.|.:.:|..||:....::.|   :..|..|
Zfish   553 CLADPGSGRFPEFSWCSDTEKPKHMYWDFKQGQAIQNRDTKRCLEISPKQTGDYKNNVFVQEC-- 615

  Fly   591 HSESQRWTIEH 601
              .:|.|.|:|
Zfish   616 --RNQHWRIQH 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	109/317 (34%)
		pp-GalNAc-T	152..461	CDD:133004	123/348 (35%)
		Ricin_B_lectin	474..597	CDD:279046	30/141 (21%)
		RICIN	481..599	CDD:238092	30/135 (22%)
galnt8b.1	XP_021331085.1	pp-GalNAc-T	147..482	CDD:133004	123/348 (35%)
galnt8b.1	XP_021331085.1	Ricin_B_lectin	494..620	CDD:306998	30/141 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810