DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgant1 and GALNT10

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_938080.1	Gene:	GALNT10 / 55568	HGNCID:	19873	Length:	603	Species:	Homo sapiens

Alignment Length:	643	Identity:	224/643 - (34%)
Similarity:	330/643 - (51%)	Gaps:	117/643 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IIFILVALCFI-------LYSKVQQNGSP--EEPPVAPLVRAAALRGHGR----------ERFEA 58
            :..:|.||..:       ||.:.|.:|:|  ....|||   ||....|.|          ::.:.
Human    12 VALVLAALVLLPNVGLWALYRERQPDGTPGGSGAAVAP---AAGQGSHSRQKKTFFLGDGQKLKD 73

  Fly    59 YSDSENEIARPATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQ 123
            :.|.| .|.|.|               |:||.||||....::.|  ||.|:.|::...|..:|::
Human    74 WHDKE-AIRRDA---------------QRVGNGEQGRPYPMTDA--ERVDQAYRENGFNIYVSDK 120

  Fly   124 LTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVD 188
            ::.|||:.|.|:|.|..:|: .::||..|::|.|.||.:|.|||||||.|:....:.:.||:|||
Human   121 ISLNRSLPDIRHPNCNSKRY-LETLPNTSIIIPFHNEGWSSLLRTVHSVLNRSPPELVAEIVLVD 184

  Fly   189 DGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGW 253
            |.||...|...|:.|: ...||  |.|||.|.|.||||.|:.||.:|||||:.|||:|||.|:.|
Human   185 DFSDREHLKKPLEDYM-ALFPS--VRILRTKKREGLIRTRMLGASVATGDVITFLDSHCEANVNW 246

  Fly   254 CEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRE 318
            ..|||.||..:|.:::.|:|||||.:||:|.|....:.: |.|.|..::..|.:|.        |
Human   247 LPPLLDRIARNRKTIVCPMIDVIDHDDFRYETQAGDAMR-GAFDWEMYYKRIPIPP--------E 302

  Fly   319 CKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSR 383
            .::.....|..||.|||||||:||::|||:|.||..::.||||..|:||::|.|||.:|.|||||
Human   303 LQKADPSDPFESPVMAGGLFAVDRKWFWELGGYDPGLEIWGGEQYEISFKVWMCGGRMEDIPCSR 367

  Fly   384 VGHIFRDFHPYKFPNDRDTHGI----NTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVML 444
            ||||:|.:.|||.|     .|:    |..|:|.||||||....:..||:.: |...|||..:..|
Human   368 VGHIYRKYVPYKVP-----AGVSLARNLKRVAEVWMDEYAEYIYQRRPEYR-HLSAGDVAVQKKL 426

  Fly   445 RKKLRCKSFEWYLKNI---YPEKFVPTK-DVQGWGKVHAVNSNICLDD--------------LLQ 491
            |..|.||||:|::..|   .|:.:.|.: ....||::..|.:.:|.|.              :..
Human   427 RSSLNCKSFKWFMTKIAWDLPKFYPPVEPPAAAWGEIRNVGTGLCADTKHGALGSPLRLEGCVRG 491

  Fly   492 NNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLRNELSCATVQHSE----------SPPYRVVMVPC 546
            ..|..:|           ..|:|:||    .|.::.....||::          ||   |.:..|
Human   492 RGEAAWN-----------NMQVFTFT----WREDIRPGDPQHTKKFCFDAISHTSP---VTLYDC 538

  Fly   547 MENDEFNEQWRY-EHQHIIHSNTGMCLDHQGLKSLDDAQV--APCDPHSESQRWTIEH 601
             .:.:.|:.|:| :.:.:.|..:|.|:|    .|..|.::  ..|:|.|.:|:|..||
Human   539 -HSMKGNQLWKYRKDKTLYHPVSGSCMD----CSESDHRIFMNTCNPSSLTQQWLFEH 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	131/282 (46%)
		pp-GalNAc-T	152..461	CDD:133004	144/315 (46%)
		Ricin_B_lectin	474..597	CDD:279046	31/149 (21%)
		RICIN	481..599	CDD:238092	29/144 (20%)
GALNT10	NP_938080.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..59		8/23 (35%)
		Catalytic subdomain A	144..253		58/111 (52%)
		GT2	145..449	CDD:224137	146/321 (45%)
		pp-GalNAc-T	148..443	CDD:133004	143/312 (46%)
		Catalytic subdomain B	311..373		39/61 (64%)
		Flexible loop	373..384		5/15 (33%)
		Ricin_B_lectin	459..587	CDD:279046	31/150 (21%)
		RICIN	461..589	CDD:238092	31/150 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810