Protein Alignment Pgant1 and GALNT9

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001116108.1
• Gene: GALNT9 / 50614
• HGNCID: 4131
• Length: 603
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 219/653 - (33%)
• Similarity: 318/653 - (48%)
• Gaps: 134/653 - (20%)

  Fly    12 LIIFILVALCFILYSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSENEIARPATQSPYE 76
            :::|:.:.| |.:|.::|  |..:|     |||..:  |..|.|        :..|:..|....|
Human    15 ILVFVGIVL-FSVYCRLQ--GRSQE-----LVRIVS--GDRRVR--------SRHAKVGTLGDRE 61

  Fly    77 QIIQ-LDLQKQKV------------------GLGEQGVAVHLSGAAKERGDEI---YKKIALNEE 119
            .|:| ||..::.|                  |||:.|:|..|    ::.|.|.   |::...|.:
Human    62 AILQRLDHLEEVVYNQLNGLAKPIGLVEGPGGLGQGGLAATL----RDDGQEAEGKYEEYGYNAQ 122

  Fly   120 LSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEI 184
            ||::::.:||:.|:|...|.:..:..| ||..|||.||.||..||:||:|||.::....:.|||:
Human   123 LSDRISLDRSIPDYRPRKCRQMSYAQD-LPQVSVVFIFVNEALSVILRSVHSVVNHTPSQLLKEV 186

  Fly   185 ILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEG 249
            |||||.||||||...||.||..|.| |.|.|:|...|.|||||||.|.:.||..|:.|.|||.|.
Human   187 ILVDDNSDNVELKFNLDQYVNKRYP-GLVKIVRNSRREGLIRARLQGWKAATAPVVGFFDAHVEF 250

  Fly   250 NIGWCEPLLQRIKESRTSVLVPIIDVIDANDF---QYSTNGYKSFQVGGFQWNGHF--------D 303
            |.||.||.|.||:|.|..:::|.||.|..:.|   ||:...:      |:.| |.:        |
Human   251 NTGWAEPALSRIREDRRRIVLPAIDNIKYSTFEVQQYANAAH------GYNW-GLWCMYIIPPQD 308

  Fly   304 WINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFR 368
            |::..:              |..|..:|.|.|..|.:||.||.::|..|..|:.:||||:|:..|
Human   309 WLDRGD--------------ESAPIRTPAMIGCSFVVDREYFGDIGLLDPGMEVYGGENVELGMR 359

  Fly   369 IWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHG-INTARMALVWMDEYINIFFL--NRPDLK 430
            :|||||::|.:|||||.||.|...||.  ||.|.:. .|..|.|.||||::.:..::  |.|...
Human   360 VWQCGGSMEVLPCSRVAHIERTRKPYN--NDIDYYAKRNALRAAEVWMDDFKSHVYMAWNIPMSN 422

  Fly   431 FHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKV-HAVNSNICLDDLLQNNE 494
            ...|.|||:.|:.||::|:|:||:|||:|:|||..|....:. :|:| ::..|..|||   |..|
Human   423 PGVDFGDVSERLALRQRLKCRSFKWYLENVYPEMRVYNNTLT-YGEVRNSKASAYCLD---QGAE 483

  Fly   495 KPYNAGLYPCGKVLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVP---CMENDEFNEQ- 555
            ....|.||||..:  .|||..::...:|:           ..|......:|   |:.:|.....
Human   484 DGDRAILYPCHGM--SSQLVRYSADGLLQ-----------LGPLGSTAFLPDSKCLVDDGTGRMP 535

  Fly   556 ---------------WRY-EHQHIIHSNTGMCLDHQGLKSLDDAQ------VAPCDPHSESQRWT 598
                           |.: :...|:...||.||:.:..|   ||.      |..|    ..|:|.
Human   536 TLKKCEDVARPTQRLWDFTQSGPIVSRATGRCLEVEMSK---DANFGLRLVVQRC----SGQKWM 593

  Fly   599 IEH 601
            |.:
Human   594 IRN 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	139/322 (43%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	35/159 (22%)
GALNT9	NP_001116108.1	Catalytic subdomain A	150..261		63/111 (57%)
		pp-GalNAc-T	154..453	CDD:133004	139/322 (43%)
		Catalytic subdomain B	318..380		31/61 (51%)
		beta-trefoil_Ricin_GALNT9	456..600	CDD:467351	36/165 (22%)