DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and GALNT18

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_940918.2	Gene:	GALNT18 / 374378	HGNCID:	30488	Length:	607	Species:	Homo sapiens

Alignment Length:	628	Identity:	194/628 - (30%)
Similarity:	293/628 - (46%)	Gaps:	84/628 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LVALCFIL------------------YSKVQQNGSPEEPPVAPLVRAAALRGHGRERFEAYSDSE 63
            ||:.|.||                  .:.|...|  :||  ||..:....:|...:..|.....|
Human    10 LVSTCVILSGMTNIICLLYVGWVTNYIASVYVRG--QEP--APDKKLEEDKGDTLKIIERLDHLE 70

  Fly    64 NEIARPATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIAL--------NEEL 120
            |.|.:...::|.:     ..:.:.....:..:..|........|    :::||        |..|
Human    71 NVIKQHIQEAPAK-----PEEAEAEPFTDSSLFAHWGQELSPEG----RRVALKQFQYYGYNAYL 126

  Fly   121 SEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEII 185
            |::|..:|.:.|.|...|....| .||||..|:|.||.||..|||||::||.:.......|||||
Human   127 SDRLPLDRPLPDLRPSGCRNLSF-PDSLPEVSIVFIFVNEALSVLLRSIHSAMERTPPHLLKEII 190

  Fly   186 LVDDGSDNVELGAKLDYYVRTRIPS---GKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHC 247
            ||||.|.|.||..||..|| .::.|   |.:.::|...:.||||:|::|.|.||..|:...|||.
Human   191 LVDDNSSNEELKEKLTEYV-DKVNSQKPGFIKVVRHSKQEGLIRSRVSGWRAATAPVVALFDAHV 254

  Fly   248 EGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREK 312
            |.|:||.||:|.||||:|..::.|..|.|..::|:...   ......||.|.....::|.|
Human   255 EFNVGWAEPVLTRIKENRKRIISPSFDNIKYDNFEIEE---YPLAAQGFDWELWCRYLNPP---- 312

  Fly   313 QRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIE 377
               :...|.|....|..||.:. |.|.:||:||.|:|..||.|:.:||||:|:..|:|||||::|
Human   313 ---KAWWKLENSTAPIRSPALI-GCFIVDRQYFQEIGLLDEGMEVYGGENVELGIRVWQCGGSVE 373

  Fly   378 TIPCSRVGHIFRDFHPYKFPNDRDTH-GINTARMALVWMDEYINIFFL--NRPDLKFHADIGDVT 439
            .:||||:.||.|...||  ..|...| ..|..|:|.|||||:.:..::  |.|......||||:|
Human   374 VLPCSRIAHIERAHKPY--TEDLTAHVRRNALRVAEVWMDEFKSHVYMAWNIPQEDSGIDIGDIT 436

  Fly   440 HRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKV-HAVNSNICLDDLLQNNEKPYNAGLYP 503
            .|..|||:|:||:|.|||.::|||..: ..|:..:|.: :::.:::|||........|.   :|.
Human   437 ARKALRKQLQCKTFRWYLVSVYPEMRM-YSDIIAYGVLQNSLKTDLCLDQGPDTENVPI---MYI 497

  Fly   504 CGKVLQKSQLFSFTNTNVLRNELSCATVQHSE--------SPPYRVVMVPCMENDEFNEQWRYEH 560
            |..:  ..|...:|::..:...:...||...:        |.| |::.....:.......|::..
Human   498 CHGM--TPQNVYYTSSQQIHVGILSPTVDDDDNRCLVDVNSRP-RLIECSYAKAKRMKLHWQFSQ 559

  Fly   561 QHIIHS-NTGMCLDHQGLKSLD---DAQVAPCDPHSESQRWTI 599
            ...|.: .:..||:.|....|:   ...:..|    ..|.|:|
Human   560 GGPIQNRKSKRCLELQENSDLEFGFQLVLQKC----SGQHWSI 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	117/284 (41%)
		pp-GalNAc-T	152..461	CDD:133004	132/314 (42%)
		Ricin_B_lectin	474..597	CDD:279046	22/135 (16%)
		RICIN	481..599	CDD:238092	22/129 (17%)
GALNT18	NP_940918.2	Catalytic subdomain A	153..267		55/114 (48%)
		pp-GalNAc-T	157..458	CDD:133004	132/314 (42%)
		Catalytic subdomain B	324..385		32/61 (52%)
		RICIN	471..598	CDD:238092	23/136 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810