DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and Galnt7

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_075215.1	Gene:	Galnt7 / 29750	RGDID:	620362	Length:	657	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	187/535 - (34%)
Similarity:	280/535 - (52%)	Gaps:	51/535 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASV 153
            |.||....:.|....|:......|:...|...|:.::.:|||.|.|...|....:| ::|.|:||
  Rat   148 GPGENAKPLVLGPEYKQAAQASIKEFGFNMAASDMISLDRSVNDLRQEECKYWHYD-ENLLTSSV 211

  Fly   154 VIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNVELGAKLDYYVRTRIPSGKVTILRL 218
            ||:|.||.:|.|:|||||.:.....|.|.||:|:||.|:...|..||..|:  ::.:|.|.:.|.
  Rat   212 VIVFHNEGWSTLMRTVHSVIKRTPRKYLAEIVLIDDFSNKEHLKEKLTEYI--KLWNGLVKVFRN 274

  Fly   219 KNRLGLIRARLAGARIA-TGDVLIFLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQ 282
            :.|.|||:||..||:.| .|.|||:||||||..:.|..||:..|.:.||...|||||||:.|.::
  Rat   275 ERREGLIQARSIGAQKAKLGQVLIYLDAHCEVAVNWYAPLVAPISKDRTICTVPIIDVINGNTYE 339

  Fly   283 YSTNGYKSFQVGGFQ-------WNGHFDWINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAI 340
            ....|      ||.:       |:....|..:|...::::.|:.|.|    |..||.||||||||
  Rat   340 IIPQG------GGDEDGYARGAWDWSMLWKRVPLTPREKRLRKTKTE----PYRSPAMAGGLFAI 394

  Fly   341 DRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFR-----DFHPYKFPNDR 400
            :|.:|:|:|.||..:..|||||.|:|::||||||.:..:||||||||:|     ...|..:....
  Rat   395 ERDFFFELGLYDPGLQIWGGENFEISYKIWQCGGKLLFVPCSRVGHIYRLEGWQGNPPPLYVGSS 459

  Fly   401 DTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNI----- 460
            .|.. |..|:..||.|||.:.|:.:||:.| ....||::.....|:...||||:|:::.|
  Rat   460 PTLK-NYVRVVEVWWDEYKDYFYASRPESK-ALPYGDISELKKFREDHNCKSFKWFMEEIAYDIT 522

  Fly   461 --YPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCGKVLQKSQLFSFTNTNVLR 523
              ||   :|.::|: ||::..:.:..|:|.:.:.|......|  ||.: :..:|||.....|.|.
  Rat   523 AHYP---LPPRNVE-WGEIRGLETAYCIDSMGKTNGGFVELG--PCHR-MGGNQLFRINEANQLM 580

  Fly   524 NELSCATVQHSESPPYRVVMVPCMENDEFNEQWRY-EHQH-IIHSNTGMCLDHQGLKSLDDAQVA 586
            ....|.|    :.|....||:.....:||.| |:| ::.| ..|..:|.|||..  :.|....::
  Rat   581 QYDQCLT----KGPDGSKVMITHCNLNEFKE-WQYFKNLHRFTHIASGKCLDRS--EVLHQVFIS 638

  Fly   587 PCDPHSESQRWTIEH 601
            .||....:|:|.:.:
  Rat   639 SCDNGKMTQKWEMNN 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	122/291 (42%)
		pp-GalNAc-T	152..461	CDD:133004	132/328 (40%)
		Ricin_B_lectin	474..597	CDD:279046	33/124 (27%)
		RICIN	481..599	CDD:238092	32/119 (27%)
Galnt7	NP_075215.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..66
		Catalytic subdomain A	206..317		53/112 (47%)
		pp-GalNAc-T	210..518	CDD:133004	131/321 (41%)
		WcaA	210..>331	CDD:223539	57/122 (47%)
		Catalytic subdomain B	381..443		38/61 (62%)
		Ricin_B_lectin	534..649	CDD:279046	33/124 (27%)
		RICIN	535..651	CDD:238092	33/125 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D606683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820