DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgant1 and GALNT8

DIOPT Version :9

Sequence 1:	NP_611043.1	Gene:	Pgant1 / 36717	FlyBaseID:	FBgn0034025	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_059113.1	Gene:	GALNT8 / 26290	HGNCID:	4130	Length:	637	Species:	Homo sapiens

Alignment Length:	587	Identity:	191/587 - (32%)
Similarity:	290/587 - (49%)	Gaps:	94/587 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 RERFEAYSDSENEIARPATQS---PYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKI 114
            |...:|.....||..:..||.   |:.|:.:        ..||.     ||.|.::...::::|.
Human    96 RPLLKAMETKVNETKKHKTQMKLFPHSQLFR--------QWGED-----LSEAQQKAAQDLFRKF 147

  Fly   115 ALNEELSEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEK 179
            ..|..||.||..||::.|.|:..|.::.:.| .||:.||::||.||..|::.|.:.|.::....:
Human   148 GYNAYLSNQLPLNRTIPDTRDYRCLRKTYPS-QLPSLSVILIFVNEALSIIQRAITSIINRTPSR 211

  Fly   180 ALKEIILVDDGSDNVELGAKLDYYVR---TRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLI 241
            .|||||||||.|.|.||...||..::   .:.| |.:.|:|...|.||.:||..|...||.||:.
Human   212 LLKEIILVDDFSSNGELKVHLDEKIKLYNQKYP-GLLKIIRHPERKGLAQARNTGWEAATADVVA 275

  Fly   242 FLDAHCEGNIGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWN--GHFD- 303
            .||||.|.|:||.||:|.||:|.||.::.|:.|.|..:.|:  .:.|: ..|.||.|.  ..:|
Human   276 ILDAHIEVNVGWAEPILARIQEDRTVIVSPVFDNIRFDTFK--LDKYE-LAVDGFNWELWCRYDA 337

  Fly   304 ----WINLPEREKQRQRRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLE 364
                ||:|.:              ...|..||::. |:.|.:|.:..|:||.|..|..:||||:|
Human   338 LPQAWIDLHD--------------VTAPVKSPSIM-GILAANRHFLGEIGSLDGGMLIYGGENVE 387

  Fly   365 MSFRIWQCGGTIETIPCSRVGHIFRDFHPYKFPNDRDTHGI--NTARMALVWMDEYINIFFL--N 425
            :|.|:|||||.:|.:||||:.|:.|...||....   |..:  |..|:|.:||||:.::.:|  |
Human   388 LSLRVWQCGGKVEILPCSRIAHLERHHKPYALDL---TAALKRNALRVAEIWMDEHKHMVYLAWN 449

  Fly   426 RPDLKFHADIGDVTHRVMLRKKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKV-HAVNSNICLDDL 489
            .|......|.|||:.|:.||:||:||:|:|||||:|| ...|...:.|:|:: :.::.|:|||
Human   450 IPLQNSGIDFGDVSSRMALREKLKCKTFDWYLKNVYP-LLKPLHTIVGYGRMKNLLDENVCLD-- 511

  Fly   490 LQNNEKPYNAG-LYPCGKVLQKSQLFSFTNTNV---LRNEL-------------SCATVQHSESP 537
              ....|.|.. :|.|         ..|::.||   |..||             .|.|.......
Human   512 --QGPVPGNTPIMYYC---------HEFSSQNVYYHLTGELYVGQLIAEASASDRCLTDPGKAEK 565

  Fly   538 PYRVVMVPCME--NDEFNEQWRYE-HQHIIHSNTGMCLDHQGLKSLDDAQVAPCDPHSESQRWTI 599
            |   .:.||.:  .:..:..|.:: ...:|:.:|..||:.:  |.|..:.|......| :|.|.|
Human   566 P---TLEPCSKAAKNRLHIYWDFKPGGAVINRDTKRCLEMK--KDLLGSHVLVLQTCS-TQVWEI 624

  Fly   600 EH 601
            :|
Human   625 QH 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	WcaA	147..426	CDD:223539	110/292 (38%)
		pp-GalNAc-T	152..461	CDD:133004	127/322 (39%)
		Ricin_B_lectin	474..597	CDD:279046	30/143 (21%)
		RICIN	481..599	CDD:238092	30/137 (22%)
GALNT8	NP_059113.1	transmembrane domain	7..29
		stem region	30..148		14/64 (22%)
		SMC_N	<48..>161	CDD:330553	19/77 (25%)
		GT1 motif	182..298		51/116 (44%)
		pp-GalNAc-T	184..485	CDD:133004	127/322 (39%)
		Gal/GalNAc transferase motif	358..397		18/39 (46%)
		RICIN	498..624	CDD:238092	31/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3736
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810