Protein Alignment Pgant1 and Galnt11

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_659157.1
• Gene: Galnt11 / 231050
• MGIID: 2444392
• Length: 608
• Species: Mus musculus
• Alignment Length: 612
• Identity: 229/612 - (37%)
• Similarity: 317/612 - (51%)
• Gaps: 81/612 - (13%)

  Fly     5 FRSFYGKLIIFILVALCFILYSKVQQ-------NGSPEEPPVAPLVRAAALRGHGR---ERFEAY 59
            |.|....:::||     :..:|:|.|       .||....|..........||.||   .:|:|
Mouse    15 FTSATWTVLLFI-----YFNFSEVTQPLRNVPIKGSGPHGPFPKKFYPRFTRGPGRVLDPQFKA- 73

  Fly    60 SDSENEIARPATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEI----YKKIALNEEL 120
                |.|         ::::...::....||.:.  :..|.....||..|:    |:|.|.|..:
Mouse    74 ----NRI---------DRLMNNHIEDPDKGLSKS--SSELGMIFNERDQELRDLGYQKHAFNMLI 123

  Fly   121 SEQLTYNRSVGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEII 185
            |.:|.|:|.|.|.||..|.::.:.:| |||||:||.|:||.:|.|||||||.:.......|.|||
Mouse   124 SNRLGYHRDVPDTRNAECRRKSYPTD-LPTASIVICFYNEAFSALLRTVHSVVDRTPAHLLHEII 187

  Fly   186 LVDDGSDNVELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGN 250
            ||||.||..:|..:||.|::..:|: ||.::|...|.||||.|:.||..|||:||:|||:|||.|
Mouse   188 LVDDSSDFDDLKGELDEYIQRYLPA-KVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVN 251

  Fly   251 IGWCEPLLQRIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQ 315
            :.|.:|||..|.|...:|:.|:||:|.|:...||::....   |||.|..||.|..:|..|..
Mouse   252 VMWLQPLLAIILEDPHTVVCPVIDIISADTLAYSSSPVVR---GGFNWGLHFKWDLVPVSELG-- 311

  Fly   316 RRECKQEREICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIP 380
                ..:....|..||||||||||::|:||.::|.||..||.|||||||:|||||.|||.:..:|
Mouse   312 ----GPDGATAPIRSPTMAGGLFAMNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFILP 372

  Fly   381 CSRVGHIFRDFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLR 445
            |||||||||...||..|..:||...|:.|:|.||:|||...:|..||||| :...|:::.||.||
Mouse   373 CSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLK-NKSFGNISERVELR 436

  Fly   446 KKLRCKSFEWYLKNIYPEKFVPTKDVQGWGKVHAVNSNICLDDLLQNNEKPYNAGLYPCG----K 506
            |||.|:||:|||.|||||..:|..                       |.||....|...|    :
Mouse   437 KKLGCQSFKWYLDNIYPEMQIPGP-----------------------NAKPQQPVLINRGPKRPR 478

  Fly   507 VLQKSQLFSFTNTNVLRNELSCATVQHSESPPYRVVMVPCMENDEFNEQWRYEHQHIIHSNTGMC 571
            |||:.:|:.. .||      .|...|...|....:|::...:..:..:.|.|...|.:..|..:|
Mouse   479 VLQRGRLYHL-QTN------KCLVAQGRSSQKGGLVLLKTCDYGDPTQVWIYNEDHELILNNLLC 536

  Fly   572 LDHQGLKSLDDAQVAPCDPHSESQRWT 598
            ||....:|.|..::..|.....||:||
Mouse   537 LDMSETRSSDPPRLMKCHGSGGSQQWT 563

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	153/308 (50%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	29/135 (21%)
Galnt11	NP_659157.1	Catalytic subdomain A	150..261		60/111 (54%)
		pp-GalNAc-T	154..452	CDD:133004	153/308 (50%)
		Catalytic subdomain B	319..381		42/61 (69%)
		beta-trefoil_Ricin_GALNT11	478..604	CDD:467318	24/93 (26%)