Protein Alignment Pgant1 and Galnt12

DIOPT Version :10

• Sequence 1: NP_611043.1
• Gene: Pgant1 / 36717
• FlyBaseID: FBgn0034025
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_766281.1
• Gene: Galnt12 / 230145
• MGIID: 2444664
• Length: 576
• Species: Mus musculus
• Alignment Length: 615
• Identity: 231/615 - (37%)
• Similarity: 324/615 - (52%)
• Gaps: 96/615 - (15%)

  Fly    12 LIIFILVALCFILYSKVQQN----GSPEEP------PVAPL--VRAAALRGHGRERFEAYSDSEN 64
            |.:..|..|..:|.::.:..    |.|..|      ||.|.  :.|.||..||
Mouse    22 LALLALAGLGALLRARSRSGTVDPGPPRTPLPGRHEPVLPRPPLPADALGAHG------------ 74

  Fly    65 EIARPATQSPYEQIIQLDLQKQKVGLGEQGVAVHLSGAAKERGDEIYKKIALNEELSEQLTYNRS 129
                        :.::|.||.:::.|.|:.|..|                .:|..||::::.:|.
Mouse    75 ------------EAVRLQLQGEELRLQEESVKQH----------------QINIYLSDRISLHRR 111

  Fly   130 VGDHRNPLCAKQRFDSDSLPTASVVIIFFNEPYSVLLRTVHSTLSTCNEKALKEIILVDDGSDNV 194
            :.:..||||.:.::|.|:||..||||.|:||.:|.|||||:|.|.|..:..|:|:|||||.||..
Mouse   112 LPERWNPLCREVKYDYDNLPKTSVVIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDRE 176

  Fly   195 ELGAKLDYYVRTRIPSGKVTILRLKNRLGLIRARLAGARIATGDVLIFLDAHCEGNIGWCEPLLQ 259
            .|..:|...: :::|  ||.::|...|.||:||||.||..|.|:||.|||.|||.:.||.|||||
Mouse   177 HLKERLANEL-SQLP--KVRLIRASRREGLVRARLLGASAARGEVLTFLDCHCECHEGWLEPLLQ 238

  Fly   260 RIKESRTSVLVPIIDVIDANDFQYSTNGYKSFQVGGFQWNGHFDWINLPEREKQRQRRECKQERE 324
            ||.|..::|:.|:|||||.|.|:|..|..:. |:|||.|...|.|..:|:||:|..|......|
Mouse   239 RIHEKESAVVCPVIDVIDWNTFEYLGNSGEP-QIGGFDWRLVFTWHVVPQRERQSMRSPIDVIR- 301

  Fly   325 ICPAYSPTMAGGLFAIDRRYFWEVGSYDEQMDGWGGENLEMSFRIWQCGGTIETIPCSRVGHIFR 389
                 ||||||||||:.:|||..:||||..|:.|||||||.||||||||||:||.|||.|||:|
Mouse   302 -----SPTMAGGLFAVSKRYFDYLGSYDTGMEVWGGENLEFSFRIWQCGGTLETHPCSHVGHVF- 360

  Fly   390 DFHPYKFPNDRDTHGINTARMALVWMDEYINIFFLNRPDLKFHADIGDVTHRVMLRKKLRCKSFE 454
               |.:.|..|.....|:.|.|.|||||:..:::...|..:.. ..||||.|..||.||:||.|:
Mouse   361 ---PKQAPYSRSKALANSVRAAEVWMDEFKELYYHRNPQARLE-PFGDVTERKKLRAKLQCKDFK 421

  Fly   455 WYLKNIYPEKFVPTKDVQGWGKVHAVNSNI---CLD--DLLQNNEKPYNAGLYPCGKVLQKSQLF 514
            |:|..:|||..||......:|.:.  |..:   |||  ...:|:.:.:...||.|..:.| :|.|
Mouse   422 WFLDTVYPELHVPEDRPGFFGMLQ--NRGLRGYCLDYNPPNENHVEGHQVLLYLCHGMGQ-NQFF 483

  Fly   515 SFTNTNVLRNEL----SCATVQHSESPPYRVVMVPCM----ENDEFNEQWRYEHQHIIHSNTGMC 571
            .:|....:|...    :|.||:..:.   .:||..|.    ||.||..|   |...::|.::..|
Mouse   484 EYTTRKEIRYNTRQPEACITVEDGKD---TLVMDLCRETVPENQEFILQ---EDGTLVHKHSRKC 542

  Fly   572 LDHQGLKSLDDAQVAP----CDPHSESQRW 597
            ::... |.||:. .||    | .:|::|||
Mouse   543 VEATE-KVLDNG-FAPYLRDC-TNSDNQRW 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pgant1	NP_611043.1	pp-GalNAc-T	152..461	CDD:133004	154/308 (50%)
		beta-trefoil_Ricin_Pgant1-like	468..601	CDD:467337	38/147 (26%)
Galnt12	NP_766281.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	38..58		3/19 (16%)
		Catalytic subdomain A	130..239		58/111 (52%)
		pp-GalNAc-T	134..428	CDD:133004	154/308 (50%)
		Catalytic subdomain B	299..361		45/71 (63%)
		beta-trefoil_Ricin-like	438..574	CDD:483949	38/144 (26%)